E-ISSN 2250-0944 | ISSN 2250-1150
 

Research Article 


Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR.

Abstract
In the present investigation, an attempt was made to formulate the time and pH dependent drug delivery system, reduce the frequency of dose administeration, and prevent ulcerative colitis by developing sustained delayed release tablets using a combination of Eudragit S-100 and L-100 as enteric coating. The core tablets of Celecoxib were prepared using the direct compresion method. The aim of the present study is to develop colon specific drug delivery of Celecoxib sustained release enteric coated tablet for ulcerative colitis using HPMC K-4M as a semisynthetic polymer. The impact of polymer concentration and superdisintegrant concentration was also studied. In-vitro drug release research was performed on the enteric coated Celecoxib tablet using simulated gastric fluid (0.1N HCl) for 2 hours, simulated intestinal fluid (pH 7.4) for 3 hours, and the simulated colonic fluid (pH 6.8) for 7 hours as a dissolution fluid. The study showed that the coating had a significant impact on the lag time before medication release. In the treatment of colonic illness and the oral administration of medications that are unstable and vulnerable to enzymatic degradation in the upper GI tract, colon drug delivery is advantageous. The results also showed that a mixture of Eudragit S-100 and L-100 may be used to coat tablets for medication delivery to the colon

Key words: Colon drug delivery system , Targeted System, Enteric coated tablet , Time and pH dependent system.


 
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How to Cite this Article
Pubmed Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . IJPRT. 2023; 13(2): 65-76. doi:10.31838/ijprt/13.02.08


Web Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . https://www.ijprt.org/?mno=137900 [Access: March 01, 2023]. doi:10.31838/ijprt/13.02.08


AMA (American Medical Association) Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . IJPRT. 2023; 13(2): 65-76. doi:10.31838/ijprt/13.02.08



Vancouver/ICMJE Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . IJPRT. (2023), [cited March 01, 2023]; 13(2): 65-76. doi:10.31838/ijprt/13.02.08



Harvard Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR (2023) Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . IJPRT, 13 (2), 65-76. doi:10.31838/ijprt/13.02.08



Turabian Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. 2023. Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . International Journal of Pharmacy Research & Technology, 13 (2), 65-76. doi:10.31838/ijprt/13.02.08



Chicago Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. "Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib ." International Journal of Pharmacy Research & Technology 13 (2023), 65-76. doi:10.31838/ijprt/13.02.08



MLA (The Modern Language Association) Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR. "Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib ." International Journal of Pharmacy Research & Technology 13.2 (2023), 65-76. Print. doi:10.31838/ijprt/13.02.08



APA (American Psychological Association) Style

RUPA RANI, V. ANJANEYULU, G.VIJAY KUMAR (2023) Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib . International Journal of Pharmacy Research & Technology, 13 (2), 65-76. doi:10.31838/ijprt/13.02.08





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