Role of Insulin Resistance and Obesity in the Pathogenesis  of Menstrual Irregularities in Women with Polycystic  Ovary Syndrome. Cross-Sectional Study

Shazia Saeed, Rozina Khan, Rizwana Naz, Shaista Gul, Zubia Bugti, Fozia Jan

Role of Insulin Resistance and Obesity in the Pathogenesis of Menstrual Irregularities in Women with Polycystic Ovary Syndrome. Cross-Sectional Study

Authors

Shazia Saeed, Rozina Khan, Rizwana Naz, Shaista Gul, Zubia Bugti, Fozia Jan

Keywords:

Polycystic ovary syndrome; insulin resistance; obesity; menstrual irregularities; HOMA-IR; oligomenorrhea; amenorrhea

Abstract

Background: Polycystic ovary syndrome (PCOS) is a widespread endocrine-metabolic disorder amongwomen at the age of reproductive age, and it is often linked with menstrual cycle disruptions, obesity, andinsulin resistance. Such metabolic abnormalities could play a major role in ovulatory dysfunction and abnormal menstrual cyclicity.

References

Lim SS, Kakoly NS, Tan JWJ, Fitzgerald G, Bahri Khomami M, Joham AE, et al. Metabolic syndrome in polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression. Obes Rev2019;20(2):339-352.

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Published

2026-01-30

How to Cite

Shazia Saeed, Rozina Khan, Rizwana Naz, Shaista Gul, Zubia Bugti, Fozia Jan. (2026). Role of Insulin Resistance and Obesity in the Pathogenesis of Menstrual Irregularities in Women with Polycystic Ovary Syndrome. Cross-Sectional Study . International Journal of Pharmacy Research & Technology (IJPRT), 16(1), 1598–1604. Retrieved from https://www.ijprt.org/index.php/pub/article/view/1744