Histopathological Effects of Metformin on Splenic Tissue in Alloxan-Induced Diabetic Rats

Abstract

Introduction: Diabetes mellitus is a chronicmetabolic disorder characterized by persistenthyperglycemia resulting from an absolute orrelative deficiency of insulin secretion bypancreatic β-cells. In addition to its systemicmetabolic effects, diabetes induces structural and functional alterations in various organs,including the spleen