To Compare the Efficacy of Arogyavardhini Vati and Kaishore Guggulu with Modern Medicine in Hyperlipidemic Patients with Raised Serum PCSK9 Levels
Keywords:
Hyperlipidemia, PCSK9, Arogyavardhini Vati, Kaishore Guggulu, Statins, Integrative Medicine.Abstract
Background: Hyperlipidemia is a major modifiable risk factor for cardiovascular diseases and is closely regulated by hepatic cholesterol metabolism. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) plays a pivotal role in low‑density lipoprotein receptor (LDLR) degradation and has emerged as an important biomarker and therapeutic target. While statins remain first‑line therapy, their adverse effects and residual cardiovascular risk necessitate exploration of integrative approaches. Ayurveda describes dyslipidemia under Medoroga and offers formulations such as Arogyavardhini Vati and Kaishore Guggulu for metabolic regulation.
Objectives: To evaluate and compare the efficacy of Arogyavardhini Vati and Kaishore Guggulu with statins in hyperlipidemic patients having raised serum PCSK9 levels, and to assess the effect of integrative therapy on lipid parameters and PCSK9.
Methodology: A comparative, interventional study was conducted on 150 hyperlipidemic patients aged 18–65 years with raised serum PCSK9 levels. Patients were randomized into three groups: Group A received statins, Group B received Arogyavardhini Vati and Kaishore Guggulu, and Group C received combination therapy. Serum LDL‑cholesterol and PCSK9 levels were assessed at baseline and after 6 months. Statistical analysis was performed using appropriate parametric tests.
Results: Baseline demographic and biochemical parameters were comparable among groups. After 6 months, all groups showed significant reductions in LDL and PCSK9 levels. The maximum reduction was observed in the combination therapy group, followed by statin monotherapy and Ayurvedic therapy. Intergroup differences were statistically significant for post‑treatment LDL and PCSK9 levels.
Conclusion: Arogyavardhini Vati and Kaishore Guggulu demonstrated significant hypolipidemic effects and reduction in PCSK9 levels. Integrative therapy with statins produced superior outcomes, supporting the role of Ayurveda as a complementary approach in dyslipidemia management.
