International Journal of Pharmacy Research & Technology (IJPRT) https://www.ijprt.org/index.php/pub <p><strong>International Journal of Pharmacy Research &amp; Technology (IJPRT) </strong>an International Journal of Pharmaceutical Research &amp; Technology <strong>(ISSN - 2250–0944) (P-ISSN 2250-1150) NLM ID: NLM ID:<a href="https://www.ncbi.nlm.nih.gov/nlmcatalog/?term=101751838">101751838</a> </strong> (An official publication of <em>Advanced Scientific Research</em>) is established in the year 2009. </p> <p>The aim of the ​<strong>International Journal of Pharmacy Research &amp; Technology (IJPRT) </strong>is to become an effective medium for inspiring the researchers to bring out their contributions in the form of research papers, articles, case studies, review articles and in the fields of Pharmacy, Medical sciences and Science and technology. The dissemination would thus help the industries, professional organisations to adopt and apply the information for creating new knowledge and enterprise. The publication would also help in enhancing awareness about the need to become research minded.</p> <p>All articles published in the journal will be freely available to scientific researchers to all over the globe. We will be making sincere efforts to promote our journal across the world in various ways. It is hoped that this journal will act as a common platform for researchers to pursue their objectives.</p> IJPRT en-US International Journal of Pharmacy Research & Technology (IJPRT) 2250-1150 Amorphous –state Characterization and Dissolution Behaviour of Efavirenz- Tocopheryl Polyethylene Glycol Succinate (TPGS)-1000 Solid Dispersions https://www.ijprt.org/index.php/pub/article/view/243 <p>The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a non - ionic surfactant. Phase solubility studies suggested that the solubility of efavirenz increased with the increase in TPGS concentration.1 absorption. Gibbs free energy (ΔG) were negative, indicatingthe spontaneous nature of efavirenz solubilization. Dispersions in different ratios were prepared using the fusion method and their physicochemical characteristics were investigated using Fourier Transform Infrared Spectroscopy(FTIR), X-ray Powder Diffraction studies(XRPD) and Scanning Electron Microscopy(SEM).A drug: carrier ratio of 1:1.5 w/w prepared by cooling the fused mixtures at 5° C showed the highest drug release of 33.27%.It was demonstrated that decrease in crystallinity of the drug and H-bonding between efavirenz and TPGS-1000 might be responsible for the enhanced dissolution rate. Analysis of dissolution data showed the best fitting with Higuchi model.</p> JASMINE KAUR RANDHAWA RABIA DHILLON NEENA BEDI Copyright (c) 2024 International Journal of Pharmacy Research & Technology (IJPRT) https://creativecommons.org/licenses/by-nc/4.0 2024-04-08 2024-04-08 14 2 1 12 Diverse Techniques on Digital Image Compression Techniques: A Meta Analysis on Medical Images https://www.ijprt.org/index.php/pub/article/view/257 <p>This paper examines a diverse array of image compression methods. This paper presents a review of existing research papers that are based on an examination of the diverse image compression methods. This paper investigates a diverse array of existing image compression techniques. The compression of binary unprocessed data is significantly different from that of an image. To resolve <br>these issues, employ a diverse array of image compression techniques. The question of how to compress an image and which techniques are employed may now arise. The two primary methods introduced for this purpose are lossless and lossy image compression techniques. Presently, the fundamental procedure is supplemented by supplementary methodologies. In specific regions, <br>neural network and wavelet-based algorithms are employed to compress images.</p> C. NANDHINI G.VIJAIPRABHU Copyright (c) 2024 International Journal of Pharmacy Research & Technology (IJPRT) https://creativecommons.org/licenses/by-nc/4.0 2024-06-21 2024-06-21 14 2 13 22 Impact and Significance of Wireless Sensor Network in Health Care: A Systematic Analysis https://www.ijprt.org/index.php/pub/article/view/258 <p>Wireless Sensor Networks (WSNs) have been used in various fields to monitor and collect data by connecting several nodes. This systematic review investigates the role and potential of WSNs in various fields such as environmental sensing, health care, manufacturing, and smart city. In comparison to wired networks, WSNs offer higher scalability, flexibility, and cost-effectiveness. <br>Some of the areas that have been affected positively include; accuracy in data collection and gathering, response to events of importance, and efficiency in energy usage. Beyond this, the importance of WSNs is also in their suitability for enabling more complex applications such as IoT, as well as in their capacity to enable heterogeneity and integration between different devices. This <br>analysis gives the recent developments in WSN technologies like low power communication protocols, security and robustness, and network management that improve the effectiveness of WSNs. This research also reveals some limitations, such as a lack of power, data privacy, and the absence of standards. The systematic analysis highlights the importance of WSNs in the enhancement of technology solutions, innovation, and handling of emerging issues in different fields.</p> R.SUDHAKAR P.SRIMANCHARI Copyright (c) 2024 International Journal of Pharmacy Research & Technology (IJPRT) https://creativecommons.org/licenses/by-nc/4.0 2024-06-21 2024-06-21 14 2 23 30 The Association between obesity and Increase severity of asthma in pediatric age group in Maternity and Children Teaching Hospital in Diwaniya City https://www.ijprt.org/index.php/pub/article/view/264 <p><strong>Background: </strong>Childhood obesity has become a significant public health concern worldwide, and its impact on respiratory conditions like as thmais of particular interest.</p> <p><strong>Aim:</strong> this research aims to assess whether obesity is associated with increased severity of asthma symptoms inchildren.</p> <p><strong>Patients and methods:</strong> The questionnaire-based study investigates therelationshipbetween obesity andtheseverity ofasthma in pediatric patients at the Maternity and Children Teaching Hospital in Diwaniya City. Datawere collectedfrom patient admitted to the hospital asinpatient and all ofthem diagnosed asa case ofasthma.The questionnaire consists of 10 questions, included age, sex, weight according toage, height according to age, BMI according to age, numbers of attack per week, type of diet, family history of asthma, level of education of the parents, and socioeconomic status. Findings were analyzed to determine any correlation between body mass index (BMI)and asthma severity.</p> <p><strong>Findings:</strong>Showed higher percentage of patients were at 4 to 5 years of age, being 44.26% to the total. Slightly higher percentage of patients were male (32, 52.46%) compared to females (29, 47.54%). Investigating weight according to age showed (18, 29.5%) patients above the 95th percentile. While height according to age presented patients (43, 70.49%) with normal findings. Investigating BMI according to age showed (17, 27.87%) patients as obese. The number of attacks were the highest in those who their attacks lasted for two weeks (18, 29.51%), and (37, 55.74%) patients were on unhealthy type of food. Most of the patients were with family history, being (44, 72%). Level of education and socioeconomic status were also investigated and showed considerable variations among patients.</p> <p><strong>Conclusion:</strong> findings provided valuable insights into pediatric asthma management strategies, highlighting the importanceof addressing obesity as a potential factorinfluencing disease outcomes.</p> SUZAN SABBAR MUTLAG Copyright (c) 2024 International Journal of Pharmacy Research & Technology (IJPRT) https://creativecommons.org/licenses/by-nc/4.0 2024-07-09 2024-07-09 14 2 31 38 Season and Ecotype Variation on Phenolic Contents, Antioxidant and Antidiabetic Activities of Diospyros Mespiliformis https://www.ijprt.org/index.php/pub/article/view/265 <p>Phenolic compounds in plants act as free radical scavengers and contribute to diabetes prevention. However, the production of plants is influenced by various factors. This study investigates the impact of season and ecology on the phenolic compound content, as well as the antioxidant and anti-diabetic activities of Diospyros mespiliformis (D. mespiuliformis) extracts.Samples (leaves, stem bark, and roots) were collected from three locations during two seasons. Phenolic compound contents were quantified using the FolinCiocalte ureagent and flavonoid content with aluminum trichloride methods. Antioxidant activity was assessed using chromogen DPPH<sup>•</sup>, ABTS<sup>+•</sup>, and Fe<sup>3+</sup>. The anti-diabetic potential of the plant was evaluated through α-amylase inhibition and glucose adsorption tests. In leaves and roots, extracts from dry-season samples showed the highest total flavonoid content. In contrast, the wet season was favorable for the production of these compounds in the bark. The DPPH<sup>•</sup> and ABTS<sup>+•</sup> radical scavenging of the extracts varied according to the season and the place where the samples were harvested (p &lt; 0.05). Fe<sup>3+</sup>chelation activity was higher in dry season samples collected at Dirabakoko. The ethylacetate fraction exhibited the strongest inhibition of α-amylase (IC<sub>50</sub>=0.185 ± 0.069 mg/mL), while the diethylether fractions demonstrated greater glucose adsorption capacity (366.66 ± 11.57 mM/g). The biomolecules in the ethylacetate and diethylether fractions of that plant could potentially be utilized to prevent oxidative stress and diabetes.</p> PAWENDE KABRE LASSINA OUATTARA YACOUBA SANOU RELWENDE JUSTIN OUEDRAOGO PAULINOUOBA MARTIN BIENVENU SOMDA GEORGES ANICET OUEDRAOGO Copyright (c) 2024 International Journal of Pharmacy Research & Technology (IJPRT) https://creativecommons.org/licenses/by-nc/4.0 2024-09-11 2024-09-11 14 2 39 50 Impact of Community-Based Nursing Intervention on Quality of Life of Elderly https://www.ijprt.org/index.php/pub/article/view/273 <p>Background: One of the biggest issues facing our generation is how to make health care systems more capable of meeting the needs of the elderly. Even when severely disabled, the majority of elderly individuals want to remain in their homes and hospitals are reducing stay times. As a result, community care has become more important. In almost every country in the world, the proportion of people aged over 60 years is growing faster than any other age group because of increased life expectancy. This demographic change has several implications for public health, especially as older age is a risk factor for many chronic diseases—diseases of long duration and generally slow progression.</p> <p>Objective: The objectives of the study were to assess the prevailing health conditions among elderly, assess the quality of life of the elderly, and evaluate the impact of community-based nursing intervention on the quality of life of the elderly.</p> <p>Material and Methods: In this study, a quantitative research approach and Quasi Experimental Non randomized control group research design were used. Non-probability convenience sampling technique was used, and eligible 264 elderly were selected in a 1:1 ratio in the control &amp; experiment group A structured questionnaire was used to assess quality of life.</p> <p>Results: The calculated t-value of 25.576 and the associated p-value of 0.0001 indicate that the improvement in the quality-of-life score after the intervention is highly significant. The p-value is less than the standard significance level of 0.05 suggesting that the observed change in the quality of life is not due to random chance but is indeed attributed to the community-based nursing intervention.</p> <p>Conclusion: These findings highlight the importance of community-based nursing intervention in enhancing the overall well-being of the elderly population and provide valuable guidance for healthcare professionals and policymakers in designing targeted interventions and healthcare services to address the specific needs of this vulnerable group.</p> Dr. Ravindra H.N Praful S. Damor Dr. Apurvakumar Pandya Dr. Aarti Muley Dr. Madhavi Sontake Copyright (c) 2024 Dr. Ravindra H.N, Praful S. Damor, Dr. Apurvakumar Pandya, Dr. Aarti Muley, Dr. Madhavi Sontake https://creativecommons.org/licenses/by-nc/4.0/ 2024-11-21 2024-11-21 14 2 51 56 A Study to Assess the Effectivenss of Personal Hygiene Module in Order to Maintain Menstrual Hygiene among Female Students of Selected Institute of University of Vadodara https://www.ijprt.org/index.php/pub/article/view/275 <p>Background: A Pre-Experimental Research Design (One Group Pre- Test and Post- Test Study). Methodology: a Quantitative research approach was used. Sample: 100 female students of Parul Institute of Nursing (PU), as research target population. Sampling Technique: A Convenience sampling technique was used to select the sample. Research tool: A Socio- demographic questionnaire and Structured knowledge Questionnaire on Menstrual Hygiene were used for collecting the data from the participants. The questionnaire was provided electronically, using Google form questionnaire. Results: The study result reveals that 90% of the participants improved their knowledge and holds good Knowledge after the administration of Personal Hygiene Module during Menstruation. Conclusion: The conclusion of the study offers insight that administration of Personal Hygiene Module during menstruation is very essential to prevent from certain reproductive tract infections and complications.</p> Amanda Da Graca Machava Prof. Takhellambam Kiranmala Chanu Mrs. Sandhya Kumari Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0/ 2024-11-21 2024-11-21 14 2 57 61 Formulation and Development of Emulgel to Enhance the Transdermal Permeability of BCS Class II Drug (Tacrolimus) https://www.ijprt.org/index.php/pub/article/view/276 <p>Topical drug delivery systems significantly improve the therapeutic efficacy of drugs. The topical route of drug delivery is the most preferred route for administration of drugs. The rationale for the development of an emulgel formulation of a drug is to enhance its therapeutic benefits, minimizing its side effect while improving the management of the diseased condition. Drug-release-retarding polymers are the key performers in such systems. The drug content was found to be in the range of 81.13 – 98.25 %. From the in-vitro drug release data, it was observed that the percentage cumulative drug release of Tacrolimus was shown by formulation F3. F3 released 99.37 % of the drug in 60 min. The ‘n’ value of optimized formulation F3 was found to be 0.717 which indicated that the drug was released by first order kinetics with anomalous (Non-Fickian) release. From the stability studies, formulation F3 doesn’t show significant difference for physical properties, homogeneity, consistency, drug content and viscosity. Based on the above evaluation studies, it could be concluded that Tacrolimus can be used as an emulgel by mixing equal quantities of a gel and emulsion portions for acute bacterial skin infection.</p> Rajashree Deshmukh Rupali Dhamdhere Copyright (c) 2024 Authors https://creativecommons.org/licenses/by-nc/4.0/ 2024-11-30 2024-11-30 14 2 62 67 Patient Perception and Satisfaction with Cervical Massage for Labour Induction: A Prospective Study in Low-Risk Pregnant Women https://www.ijprt.org/index.php/pub/article/view/279 <p>Introduction: Cervical massage is a technique aimed at stimulating cervical ripening by encouraging the release of natural prostaglandins. It may reduce the need for medical induction by promoting the normal physiological onset of labour. Although studies have shown its potential to soften and efface the cervix, there is limited research on patient perception and satisfaction with this method. This study explores women's pain perception and satisfaction with cervical massage as an alternative to more invasive induction methods, such as membrane sweeping.</p> <p>Methods: This prospective, mono-centric study was conducted among low-risk pregnant women at a tertiary care hospital in Eastern India. The participants underwent cervical massage once they reached their expected date of delivery (EDD). Exclusion criteria included women with growth-restricted foetuses or those requiring formal induction. Data on pain during the procedure were collected using a Visual Analogue Scale (VAS). Postnatal questionnaires assessed patients' experiences, including whether they would recommend or repeat the procedure.</p> <p>Results: Of the 203 women screened, 104 were enrolled (52 primiparas and 52 multiparas). The majority (93%) had a single cervical massage. Pain scores ranged from no pain (31.73%) to moderate pain (16.35%). Regarding satisfaction, 38.46% of participants would recommend the procedure to others or agree to repeat it in subsequent pregnancies. The interval between cervical massage and labour onset was noted, with a higher rate of vaginal delivery among multiparas. Only 0.96% had prior knowledge of cervical massage.</p> <p>Discussion: While cervical massage showed less discomfort compared to membrane sweeping, only 38.46% of women would consider repeating it. This supports the need for further research on its effectiveness for cervical ripening and induction. The study highlights the need for more alternatives to formal induction methods.</p> <p><strong>Conclusion:</strong> Cervical massage is a promising alternative to membrane sweeping, but its efficacy and patient acceptability require further investigation.</p> <p><strong>&nbsp;</strong></p> <p><strong>&nbsp;</strong></p> Dr. Avishek Bhadra Dr. Arup Chakraborty Dr. Rumela Biswas Dr. Subhojit Bagchi Copyright (c) 2024 Authors https://creativecommons.org/licenses/by/4.0/ 2024-12-09 2024-12-09 14 2 68 72