International Journal of Pharmacy Research & Technology (IJPRT)

Successful Management of Cervical Ectopic Pregnancy in a Primigravida with Dilation and Evacuation: A Case Report

Dr. Avishek Bhadra — 2025-01-07

Cervical ectopic pregnancy (CEP) is a rare and potentially life-threatening condition, particularly in primigravid patients. This case presents a 20-year-old primigravida with painless vaginal bleeding at 8 weeks of amenorrhea, diagnosed with CEP via early pregnancy ultrasound. The patient underwent a successful emergency dilation and evacuation (D&E) procedure, preserving fertility and preventing excessive hemorrhage. Postoperative recovery was uneventful, and follow-up ultrasound confirmed complete evacuation. This case highlights the importance of early diagnosis and careful management of CEP, particularly in terms of preserving future fertility and minimizing complications like hemorrhage and cervical insufficiency.

Study of Surgical Methods of Umbilical Hernia Repair in the Rural District of Chickballapur

Dr. Sunita Prakash — 2025-02-05

Background: Umbilical hernias are a frequent surgical issue, especially in rural areas. This study aims to assess the surgical techniques for umbilical hernia repair in the rural district of Chickballapur, Karnataka, India, and to compare the outcomes of open repair with primary sutures, open repair with mesh reinforcement, and laparoscopic repair.

Methods: This retrospective cohort study analyzed 100 adult patients who underwent surgery for symptomatic umbilical hernias at s 1 -District hospital and 4 taluk hospitals in Chickballapur from January 2019 -January 2024. Data on the type of surgery, postoperative complications, recovery times, recurrence rates, and functional recovery were collected. Statistical comparisons were made to evaluate the outcomes of different surgical approaches.

Results: A total of 100 patients were included in the study. Of these, 50% (n=50) underwent open repair with primary sutures, 30% (n=30) had open repair with mesh reinforcement, and 20% (n=20) received laparoscopic repair. Laparoscopic repair was associated with the lowest postoperative complication rate (3%), the shortest recovery time (mean 5 days), and the lowest hernia recurrence rate (2%). In comparison, open repair with mesh showed a recurrence rate of 6%, while primary suture repair had a higher recurrence rate of 10%. Socio-economic factors and resource availability influenced the choice of surgical method.Conclusion: Despite the prevalence of open repair techniques in this rural setting, laparoscopic repair yielded the best outcomes in terms of complications, recovery time, and hernia recurrence. This suggests that laparoscopic repair could be a beneficial option for rural areas with the necessary surgical expertise and equipment. Further research is recommended to explore the broader applicability and cost-effectiveness of laparoscopic repair in low-resource environments.

Incidence of Associated Injuries in Patients with ACL Tear on MRI – An Observational Study

Dr. Varun S. — 2025-02-08

Background

Anterior cruciate ligament (ACL) injuries are common, particularly in athletes, and often occur with additional knee injuries, including meniscal tears, ligamentous damage, and bone bruises. Identifying the incidence of these associated injuries is critical for optimizing treatment and improving recovery outcomes.

Objectives

This study aims to determine the incidence of associated injuries in patients with ACL tears and to explore the demographic profile and injury mechanisms that contribute to these additional knee injuries.

Methods

A multicentre, prospective observational study was conducted from December 2023 to December 2024, involving 200 patients diagnosed with ACL tears confirmed via MRI. Associated injuries such as meniscal tears, collateral ligament injuries, cartilage damage, and bone bruises were documented. Data on injury mechanisms, demographics, and sports participation were collected.

Results

Out of the 200 patients, 50% (n=100) had at least one associated injury. Meniscal tears were the most common (42%), followed by bone bruises (22%) and MCL injuries (18%). The majority of ACL injuries were due to non-contact mechanisms (60%), with football and basketball being the most frequent sports.

Conclusion

ACL tears frequently occur with associated knee injuries, particularly meniscal and ligamentous damage. These findings highlight the need for comprehensive diagnostic and treatment strategies to address multiple injuries and improve rehabilitation outcomes.

Morphometric Analysis of Glenoid, Coracoid Process and Scapular Spine in a tertiary care center- 3D CT Study

Dr Mozimul Haq Siddiqui — 2025-02-11

Background: Recurrent anterior shoulder instability with glenoid bone loss poses a significant challenge in orthopedic practice. Achieving favourable functional outcomes depends on selecting an appropriate graft type and ensuring its safe fixation on the glenoid. Despite the importance of morphometric data, there is a paucity of studies analyzing the dimensions of the glenoid, coracoid process, and scapular spine in a tertiary care Center. Purpose: To evaluate the morphometric dimensions of the glenoid, coracoid process, and scapular spine in the Indian population, which can guide clinical decisions in managing recurrent anterior shoulder instability. Methods: A total of 3D CT scans of 300 shoulders from 150 patients with non-orthopedic conditions were analyzed. Measurements included: Glenoid: Mean height and width. Coracoid process: Mean height, width, and length of harvestable coracoid. Scapular spine: Mean width and length of harvestable segments. Results: This study highlights important morphometric data on the glenoid, coracoid process, and scapular spine among the Indian population. The results have direct clinical relevance, especially in addressing recurrent anterior shoulder instability with glenoid bone loss. The key findings include: Glenoid Dimensions: Mean height of 34.8 mm and mean width of 24.6 mm. Coracoid Process Dimensions: Mean height of 8.2 mm and 9.3 mm, and mean width of 11.7 mm and 13.1 mm at fixation points. Harvestable coracoid length averaged 21.9 mm. Scapular Spine Dimensions: Mean width of 8.2 mm and 7.7 mm at fixation points, and mean harvestable length of 30.4 mm. Gender Differences: Statistically significant differences in measurements were observed between genders. Conclusions: This morphometric evaluation can guide surgeons in selecting appropriate grafts and fixation techniques tailored to patient anatomy, potentially improving functional outcomes in cases of recurrent shoulder instability.

Clinical Study of Gynecological Problems in Adolescent Age Group at Tertiary Care Center

Dr. karalla chandana — 2025-02-12

Background: According to WHO adolescence is the age between 10-19 years Adolescents constitute 21.4% of the population in India [1]. It is the period where enormous physical and psychological changes occur. Hormonal events play a key role in this transition. Profound bodily changes, sexual development and altered emotional and behavioural changes are observed during this period, besides endocrine influences, genetic, nutritional and other environmental factors play an important role during this transitional period of life.

Aim and Objectives: 1. Clinical study of gynaecological problems in adolescent age group at tertiary care center. 2. To study proportion of different gynaecological problems in adolescent girls.3.To study the etiological factors in different gynaecological problems in adolescent girls.4.To study the treatment modalities in different gynaecological problems in adolescent girls.

Methods: Study Design: Cross sectional study. Study place: OBGY Department of VDGMC Latur, Maharashtra, India. Study Duration: September 2022 to May 2024. Study population: The study was conducted on all adolescent girls who were from urban and rural surroundings of tertiary care center visited the gynecology OPD. Study sample: 180

ResuResult: Majority of gynecological problems are present in late adolescent age group. In 180 cases admitted cases are 12 cases [6.66%] and 168 cases [93.3%] are from OPD.

26 cases who has normal menstrual patterns presented with dysmenorrhea (14 cases) and 8 cases with leucorrhea and 3 cases with dysuria and 1 case with mass per abdomen. most of the cases presented with hirsutism and acne 40 cases (22.22%) followed by Leucorrhoea and itching 29 cases (16.11%), Teenage pregnancy found in 12 cases (6.66%), overweight 6 cases(3.33%), Mass per abdomen 6 cases(3.33%), dysuria 3 cases (1.66%), Precocious puberty 1 case (0.55%) and Delayed puberty 1 case (0.55%).

most common etiopathology was AUB 96 cases (53.33%) followed by PCOS 39 cases (21.66%) and 4 cases diagnosed with Mullerian agnesis (2.22%),14 cases (7.77%)thyroid disorders, 06 cases(3.33%) hyperprolactinemia, 10 cases with vaginal infections and 02 cases with urinary tract infections. most common treatment modalities was Hormonal treatment 56 cases (31.11%) followed by Iron tablets in 59cases (32.77%), Blood transfusions in 2 cases(1.11%),Tranexamic acid in 38cases (21.11%), Mefenamic acid in 32 cases(17.77%),Thyroxin in 14cases[7.77%],Surgery in 10 cases (5.55%),Cabergoline in 4 cases[2.22%],antifungal in 4 cases (2.22%) , Antibiotics in 6 cases[5.55%], AKT in 1 case(0.55%). Many girls treated with multiple modalities.

Conclusions: Dysmenorrhea and heavy menstrual bleeding as predominant symptoms and excessive weight gain is most common examination finding. Majority of cases treated with hormonal treatment and iron supplementation.

Formulation, Optimization and Evaluation: Piroxicam Emulgel for Topical Drug Delivery Systems

Meenakshi Bhatia — 2025-02-13

Piroxicam is nonsteroidal anti-inflammatory drug that is classified as BCS class II drug (low solubility and high permeability). In the present study preparation of piroxicam loaded emulgel for the topical drug delivery is optimized by the central composite experimental design. The effect of different concentrations of surfactants i.e., span-80 & tween-80 was investigated on zeta potential (mv), polydispersity index (PDI), particle size (nm) & entrapment efficiency. The optimized batch of formulation suggested by the central composite design (CCD) was characterized by Fourier transform infrared spectroscopy (FT-IR) & Transmission electron microscopy analysis and also the mechanical and rheological properties were studied. The optimized batch of the formulation possess adequate spreadibility and viscosity. Results of in-vitro release studies revealed that the drug loaded emulgel showed (91.10 %) release in 12 hours dissolution study whereas in-vitro antiinflammatory study determined by egg albumin denaturation method exhibited 98.88% inhibition. However, ex-vivo bioadhesion study displayed the comparable results between piroxicam loaded emulgel (0.036 ± 0.4 N) and marketed Pirox® gel (0.037 ± 0.15). Hence, piroxicam when loaded in emulgel can be administered topically with improved properties.

Correlation of Gestational Age by Last Menstrual Period, Ultrasonography and New Ballard’s scoring

Dr Indra N — 2025-03-03

Background: Gestational age or menstrual age is the time elapsed from the first day of last menstrual period (LMP), a time that precedes conception. The accurate calculation of gestational age holds key role in prevention of preterm birth; hence the study attempts to find which method gestational age calculation is more accurate.

Methods: prospective observational study with 179 participants whose gestational age was assessed using last menstrual period (LMP), ultrasonography (USG) and New Ballard scoring (NBS) which is considered gold standard.

Results: The mean age of the mother in our study is 24.68 years with a standard deviation of 3.99 and the mean birth weight of babies in our study is 2.80 kg with a standard deviation of 0.45. Pearson coefficient correlation is 0.677 (P <0.001) when comparing gestational age by LMP and gestational age by NBS which is statistically significant. A correlation of 0.779 (P <0.001) was found while comparing gestational age by T1 USG and NBS which was also found to be significant.

Conclusion: T1 USG is more consistent with NBS when compared to LMP gestational age, even though both have positive correlation with NBS.

Evaluation of Cardiac Autonomic Function Testing In a Tertiary Care Hospital

Arun Kumar Moha — 2025-03-05

Introduction: The autonomic function testing (AFT) refers to the evaluation of the sympathetic, and parasympathetic division of autonomic nervous systems (ANS). The system affects function of almost every organ system in the body; hence, many tests that seem unique to a particular organ are really tests of autonomic function (e.g., urodynamic studies, gastric motility testing, pupillometry, tests of salivary and lacrimal gland secretion, etc.). Through scientific research and clinical experience published in peer-reviewed journals, autonomic function testing has proven its worth in the diagnosis and treatment of autonomic disorders over the past many years. Autonomic testing is now considered as a crucial part of the clinical assessment.

Materials and methods: The present work was designed and conducted in the Department of Physiology at Sri Siddhartha Institute of Medical Sciences & Research Centre (T Begur), Sri Siddharatha Academy of Higher Education., Tumkur over a period of 12 months. Fifty healthy male subjects doing MBBS in the same college between 19-24 years volunteered to participate in the present study. On the basis of detailed family history, participants were divided into two groups of twenty-five each as study group- with family history of hypertension (FH+) and control group- without any family history of hypertension (FH-). Either or both parents of the subjects of study group presented with history of hypertension of varying degree and duration and were under antihypertensive therapy which was further confirmed by their medical prescriptions as well. Both the groups were assessed and compared for their autonomic function tests to find out hyper-reactors for those having higher risk for hypertension in future. Sample size of 50 participants was decided including both the groups due to lack of consent from most of the senior MBBS students.

Results: There were no significant differences between age, BMI and other physical indices between two groups. All the physical characteristics of subjects of control as well as study group were statistically matched (p >0.05). However, the resting heart rate, systolic and diastolic blood pressures were found to be marginally higher (p>0.05) in the study group (Table 1). There was higher and significant (p <0.001) rise in diastolic blood pressure following isometric hand grip test at 1/3 of MVC and cold pressor tests in study group as compared with the control group indicating an attenuated sympatho-adrenergic system in subjects of study group (Table 2).

Conclusion: It may be concluded that sympathetic nervous system hyperactivity develops in children of hypertensive parents whereas the PNS remains unaltered. Though the subjects of study group may be normotensive initially, there is possibility of development of hypertension in future. Hyper-reactors who have positive family history were more vulnerable to future hypertension due to their sympathetic over activity. Regular monitoring of autonomic activity may prove to be a useful tool in predicting the future hypertensive cases. It also appears that genetic and environmental factors might be responsible for essential hypertension in families.

"Lupus And Anti-Dsdna: Does Anti-Dsdna Level Correlate With Disease Activity? – A Case Report."

Dharankumar P. — 2025-03-06

Background: Systemic lupus erythematosus is a chronic autoimmune disease that mostly affects women. Approximately 50% of lupus patients experience lupus nephritis. In about 2% of cases, immune thrombocytopenia can develop into systemic lupus. High anti-dsDNA levels and low complement levels often mark disease activity. Anti-dsDNA levels are important in disease pathogenesis and correlate with disease activity. We are reporting a case of anti-dsDNA-negative lupus nephritis. Case report: A 26-year-old female presented with complaints of bilateral lower limb swelling and facial puffiness for a month. She was evaluated for thrombocytopenia around 6 months back and was labeled as a case of Immune thrombocytopenia she was not on any steroid therapy at the time of presentation with us. She was evaluated for the current complaints and a provisional diagnosis of nephrotic syndrome with suspicion of lupus nephritis as the primary pathology was made. Renal biopsy was done after building up her platelets and her biopsy revealed stage 5 lupus nephritis. However, her immunological profile showed a negative anti-dsDNA. She was started on mycophenolate mofetil (MMF) along with steroids, hydroxychloroquine, and Tacrolimus. Following drug therapy there was a significant reduction in proteinuria and remission was achieved. Conclusion: Anti-dsDNA titers are strongly associated with systemic lupus erythematosus disease activity, particularly in lupus nephritis. Managing lupus nephritis typically involves immunosuppressive medications, which can have adverse effects on reproductive health. Our case report examines the role of anti-dsDNA titers in lupus and guides in managing lupus nephritis in women of reproductive age.

Study of Dominance in the Foramen of Human Crania in Maharashtra Region

M. M. Peerzade — 2025-03-06

Background: 104 non - pathological dried adult cranial bases studied for dominance of various foramina by using hand lens. Jugular foramina (70.19%), Superior Orbital Fissure (30.2%), Foramina ovale (32.3%), Carotid Canal (21.5%), optic canal (4%) were dominant on right side, statistically highly significant (P<0.01) with Chi. Square (x2) goodness of fit test. While Inferior orbital fissure (19.38%), foramen Rotundum (25%), foramina spinosum (24.7%), stylomastoid foramina (14.4%), internal acoustic meatus (20.3%) were dominant on left side & statistically highly significant (P<0.01) with Chi. Square (x2) goodness of fit test. This study will certainly help the radiologists because CT scan, MRI does not show exact footage of the foramina, moreover the dominance of these foramina will also help the Neurosurgeons during the surgery of basal crania. Moreover Medico- legal expert, Anthropologist, Anatomist to specify the Maharashtra state crania from other state crania.

A Multicenter Hospital Based Study on Prevalence of Lumbar Intervertebral Disc Herniation in Asymptomatic Individuals on MRI

Dr. Varun S. — 2025-03-06

Background:
Lumbar intervertebral disc herniation (LDH) is a common spinal disorder often associated with clinical symptoms such as low back pain and sciatica. However, recent studies have shown that a significant proportion of individuals with lumbar disc herniation remain asymptomatic. The role of magnetic resonance imaging (MRI) has become central in detecting these disc abnormalities, even in the absence of symptoms. Understanding the prevalence and characteristics of asymptomatic lumbar disc herniation can guide clinical decision-making and improve the management of patients presenting with back pain.

Objective:
This study aimed to assess the prevalence and types of lumbar intervertebral disc herniation and the degree of disc degeneration in asymptomatic individuals using MRI. The study also sought to evaluate the correlation between demographic factors and these abnormalities.

Methods:
A cross-sectional, hospital-based study was conducted over one year, including 200 asymptomatic individuals who underwent lumbar MRI for non-spinal conditions. Demographic data were collected, and MRI scans were analyzed for disc degeneration using the Pfirrmann grading system (Grades 1-5) and the presence of lumbar disc herniation, categorized as normal, bulge, protrusion, extrusion, or sequestration.

Results:
The prevalence of lumbar disc herniation in this asymptomatic population was 30%, with the majority of herniations occurring at the L4-L5 (40%) and L5-S1 (35%) levels. Disc bulge was the most common type of herniation (20%), followed by protrusion (7%). Extrusion and sequestration were rare (5% combined). Regarding disc degeneration, Grade 1 (normal) degeneration was observed in 55% of the cases, while Grade 4 (severe) degeneration was seen in 5%. The prevalence of herniation increased with age, particularly among individuals aged 40 and above (35% versus 25%).

Conclusion:
This study reinforces the concept that asymptomatic lumbar disc herniations are common and emphasizes the need for careful interpretation of MRI results in clinical practice. The findings underscore that disc abnormalities detected on imaging should be assessed in the context of symptoms, as many individuals with disc herniation may not require intervention.

Study Of The Efficacy, After Giving Equal Bolus Dose Of 8ml Of Ropivacaine 0.1% Vs Ropivacaine 0.2% With Fentanyl For Post-Operative Patient-Controlled Epidural Analgesia In Patients Undergoing Infra- Umbilical Abdominal Surgery And Lower Limb Orthopedic

K. Harini — 2025-03-08

Background: Epidural analgesia is widely accepted as the prime modality of providing optimal post-operative analgesia after major surgery, and patient-controlled epidural analgesia (PCEA) has recently gained popularity. It is often used in the post-operative phase and can be given as boluses, infusions, or a combination of the two. Local anesthetic has been used as the mainstay for epidural analgesia, alone or in combination with opioids. Ropivacaine is a relatively new amino amide local anesthetic, with Fentanyl is the opioid often used. Aims and Objectives: To study the efficacy, after giving 8ml bolus dose of ropivacaine 0.1% versus 0.2% with fentanyl for postoperative patient-controlled epidural analgesia in patients undergoing infra-umbilical abdominal and lower limb orthopedic surgery at Pravara Rural Hospital, Loni. Materials & methods: 74 patients were included in the study where the patients were divided into two groups with Group 1 given Ropivacaine 0.1% with Fentanyl 2 µg/ml and Group 2 given Ropivacaine 0.2% with Fentanyl 2 µg/ml. The PCEA pump will be programmed to deliver a continuous epidural infusion at the rate of 8 ml/hour after the initial 8 ml bolus dose, with a PCEA bolus dose of 4 ml and lockout interval of 20 minutes. Postoperatively the intensity of pain by vas score, degree of motor blockade, level of sedation, the total volume of drug infused, variation in hemodynamic parameters, and adverse effects were observed. Results: Group 1 reported a mean VAS, significantly higher than Group 2's mean VAS. Overall, the data suggest that Group 1 consistently experiences higher VAS scores compared to Group 2 across the measured time intervals, indicating potentially differing levels of perceived discomfort or pain between the two groups. Conclusion: Ropivacaine 0.2% with fentanyl is more efficacious than Ropivacaine 0.1% with fentanyl when used as PCEA in the postoperative period for analgesia.

Early Detection and Intervention for Hearing Impairment in Vietnamese Children Aged 0-6 Years

Nguyen Thi Trung Thuy — 2025-03-11

Hearing impairment during early childhood poses a significant challenge to speech and language development, with long-term consequences on cognitive and social integration. This study systematically investigates the prevalence, associated risk factors, and effectiveness of early intervention for hearing impairment in children aged 0-6 years who underwent audiological assessment at the Audiology Department of the National Otorhinolaryngology Hospital of Vietnam. A total of 72 children were comprehensively evaluated using a combination of objective and subjective audiological tests, including otoacoustic emissions (OAE), auditory brainstem response (ABR), and auditory steady-state response (ASSR). The findings reveal that 40.2% of children were diagnosed with hearing impairment before six months of age, reflecting the increasing impact of neonatal hearing screening programs. However, 29.1% of cases were only identified after three years of age, indicating a substantial delay in diagnosis for a significant proportion of children. Bilateral hearing loss was the predominant presentation, affecting 93.1% of the cases, with profound hearing loss accounting for 65.1% of the affected children. Notably, early intervention demonstrated a measurable impact on access to hearing rehabilitation. The proportion of children utilizing hearing aids increased from 4.5% before diagnosis to 20.9% following audiological evaluation, while cochlear implantation rates rose from 0% to 7.5% after diagnosis. This study underscores the critical importance of early hearing screening and prompt intervention to mitigate the developmental consequences of hearing impairment. Furthermore, it highlights the necessity of raising parental awareness and improving access to advanced audiological services to enhance early detection and effective management. The research provides new insights into the epidemiology of pediatric hearing impairment in Vietnam and emphasizes the urgent need for systematic neonatal hearing screening programs across healthcare facilities nationwide. Through these efforts, the study contributes to bridging the gap in early diagnosis and intervention, ultimately fostering better long-term outcomes for children with hearing impairment.

A Correlative Study on IL-6, TNF-Α, Deoxypyridinoline (DPD) In Patients with Hyperparathyroidism & Healthy Individuals

Dr. Akansha Srivastava — 2025-03-17

Hyperparathyroidism is associated with metabolic disturbances, including alterations in cytokine levels and bone resorption markers. This case-control study aims to evaluate the correlation of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and deoxypyridinoline (DPD) levels in 150 patients with hyperparathyroidism and 150 healthy individuals. The study examines differences between these groups, using statistical analysis and graphical representations in the form of histograms and pie charts. The findings contribute to understanding the inflammatory and bone degradation processes in hyperparathyroidism.

ENGINEERING DREAMS, ENDURING STRESS: THE HEAVY TOLL OF STRESS ON ENGINEERING STUDENTS: A CROSS-SECTIONAL STUDIES

Janhavi Sarva, Kanika Gupta, Keshav Aggarwal, Ruchita Dixit, Amol R. Patil — 2025-03-26

Background: The pressure of professional courses like engineering and medicine often takes a toll on students, leading to stress, anxiety, and health issues. Heavy workloads and packed schedules disrupt sleep and eating habits, worsening stress over time. This study analyses stress factors among engineering students through a survey-based quantitative approach.

The study of brachial plexus anatomical variations in the Indore region variations in its formation, branching, and running

Umesh kumar mehta, Dr.Pawan kumar mahato, Dr Mukta Shreeram Pande — 2025-03-26

Background: The brachial plexus, a sophisticated network of nerves, plays a pivotal role in clinical anatomy, surgery, and anesthesia, as it is responsible for the motor and sensory innervation of the upper limb. This neural network, which arises from the anterior rami of the C5 to T1 spinal nerves, navigates intricate anatomical regions prior to diverging to innervate the integumentary system and musculature.

To determine morphometric analysis, vertical head diameter, foveal diameter, fovea transverse diameter, and foveal longitudinal diameter of the proximal femur in individuals from Central India

Dr.Asha Changil,Dr. Anjali patil,Dr. Rajendra singh — 2025-03-26

Background: The proximal femur, vital for human skeletal system, plays a vital role in hip joint biomechanical functions and is essential for medical and anthropological applications due to its anatomical dimensions. Aim: To determine the regional differences in this anatomical location by doing a thorough morphometric investigation of the vertical head diameter, foveal diameter, fovea transverse diameter, and foveal longitudinal diameter of the proximal femur.

To estimate the glucose and lipid profile levels in Diabetes without Nephropathy and in diabetic nephropathy patients

Maneesh Kumar Singh, Dr. Shreya Nigoskar — 2025-03-26

Background: Hyperglycemia, which results from impairments in insulin secretion, insulin action,or a combination of both, distinguishes diabetes mellitus (DM), a chronic metabolic condition. The way glucose metabolism and lipid homeostasis work together are a key part of how diabetic complications like nephropathy start and get worse. Aim: The study aimed to compare glucose and lipid profiles in diabetic patients without nephropathy with those affected by diabetic nephropathy

Synthesis and Characterization of Pullulan Encapsulated Ursolic Acid Nanoparticles for Enhanced Bioavailability and Acetylcholinesterase Inhibition in Alzheimer’s Disease Therapy

Aditi Kaushik, Sushila Kaura, Richa Mor — 2025-03-26

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to cognitive decline and memory loss, primarily due to the dysfunction of acetylcholinesterase (AChE) in the brain. Natural compounds, such as Ursolic Acid (UA), have demonstrated significant neuroprotective and anti-inflammatory effects. However, the therapeutic potential of UA is often hindered by its low solubility and poor bioavailability. To address these limitations, we synthesized Pullulan-encapsulated Ursolic Acid nanoparticles (UA-Pull-NPs) with the aim of improving drug delivery efficiency and enhancing AChE inhibition in AD therapy.

Comparative evaluation of result after internal fixation of clavicle fracture with titanium elastic nail and plate

2025-03-26

Objective: This study evaluated the outcomes of using titanium elastic nail (TEN) fixation in combination with plate fixation to treat midshaft clavicle fractures. Methods: 60 patients with displaced midshaft clavicle fractures were randomly assigned to either Group A (TEN fixation) or Group B (Plate fixation). At six weeks, three months, and six months following surgery, a number of factors were assessed. Surgical duration, intraoperative hemorrhage, radiological union time, functional results, and complications were among them.

Glue Sniffing Neuropathy in an 18-Year-Old Male Butcher with a History of Weed Smoking: Case Report

Allareddy Sathvika — 2025-03-27

Glue sniffing neuropathy, a consequence of volatile substance abuse, presents with peripheral nerve damage. We present a case of an 18-year-old male butcher with a history of chronic glue sniffing and occasional marijuana use. He presented with a three-month history of progressive muscle weakness, small muscle wasting, hypotonia, hyporeflexia, and ascending quadriparesis. This case highlights the neurological repercussions of inhalant abuse, particularly in adolescents.

A Retrospective Comparative Study of Surgical Management of 4 Part Proximal Humerus Fractures between Internal Fixation with Philos Plate and Hemi Replacement with Neers Prosthesis

Dr P Amarnath Reddy — 2025-03-27

Background: Neer recommended open reduction and internal fixation (ORIF) for three-part fracture dislocations and primary hemiarthroplasty (HA) for four-part fracture dislocations and for fractures with greater than 50% of cartilage-covered articular defect. The current study was conducted to compare surgical management of four part proximal humerus fractures between internal fixation vs hemi replacement.

Methods: The study is a hospital based retrospective case study, conducted in Government General Hospital, Kurnool during the period of June 2022 to June 2024. 30 patients (adults) presenting with proximal humerus fractures with a follow up period of minimum of 6 months and maximum of 18 months were included. After surgery, all patients were examined six weeks, three months, and six months later, as well as every two weeks until a fracture had healed. The constant Score were evaluated at each visit. A shoulder with affected arm X-ray was taken to check for fracture union and implant-bone interaction.

Results: In this study maximum age was 80 years and a minimum of 50 years with an the average age of 64.4 years. Significant differences were observed in all complications between range of movements between the two groups. Average time taken for internal fixation by hemiarthroplasty procedure was 120mins as compared to Philos which was100minutes.Blood loss was measured in terms of suction drain collection and mop count. The average amount of blood loss was 216 ml for PHILOS procedure and 356 ml for HEMIREPLACEMENT procedure.

Conclusions: the ROM pertaining to flexion, abduction, internal rotation, and external rotation for individuals with Philos plating was 17%, 20%, 4% and 4.6% higher than those who received Neer’s hemiarthroplasty. In conclusion, our study suggests that Philos plate osteosynthesis may have superior results than hemiarthroplasty when treating four-part proximal humerus fractures in individuals aged fifty and above.

Effect of Heartfulness Meditation Practices on Blood Pressure and Quality of Life in Patients with Hypertension – A Randomized Clinical Study

Vijaya Chandra Reddy Konda — 2025-03-27

Background: Heartfulness meditation practices are modified form of Raja Yoga and gaining popularity worldwide. Studies have demonstrated the beneficial effects of heartfulness meditation on physical health, psychological health, emotional intelligence, heart rate variability, sleep and even on telomere length.

Methods: This is a randomized control study conducted in patients with hypertension to assess the effect of heartfulness meditation practices on blood pressure and quality of life. A total of 112 participants were randomized in 1:1 ratio to either intervention group or control group for a study period of four months. Intervention group were trained on heartfulness meditation practices by certified trainers on three consecutive days and were asked to practice them daily at their home. Quality of life was assessed by MINICHAL scale.

Results: After the intervention, there was a significant reduction in mean systolic and diastolic blood pressure in the intervention group compared to baseline (136.71 ± 8.64 vs 130.31 ± 8.78, p <0.001 for systolic BP and 82.78 ± 7.30 vs 77.44 ± 7.55, p <0.001 for diastolic BP). Comparison of BP changes between both the groups after the intervention showed significant reduction in both systolic (p=0.009) and diastolic BP (p=0.002) in the intervention group. There was also a significant improvement in mental domain, somatic domain, and overall quality of life in the intervention group.

Conclusion: The four months heartfulness meditation practices resulted in a significant reduction in the mean systolic and diastolic pressures. There was also improvement in the scores related to various aspects of quality of life.

Assessment of Nerve Conduction Abnormalities in Peripheral Vascular Disease: A Clinical and Electrophysiological Correlation Using Nerve Conduction Studies and Ankle-Brachial Index in Patients with Chronic Ischemia

Dr. M. Arafath Natchiar — 2025-03-28

Background: Peripheral Vascular Disease (PVD) is a progressive circulatory disorder characterized by arterial narrowing, leading to reduced blood flow to the extremities. Chronic ischemia associated with PVD can cause significant neurological complications, including peripheral neuropathy. However, distinguishing between neuropathy caused by ischemia and other factors, such as diabetes, remains a challenge. Nerve conduction studies (NCS) serve as an objective tool to evaluate peripheral nerve function in PVD patients. This study aimed to assess nerve conduction abnormalities in PVD patients and correlate findings with disease severity.

Methods: A prospective observational study was conducted on 40 patients diagnosed with PVD at Krishna Hospital, Karad, between May 2011 and May 2013. Patients were classified based on the Fountaine Staging System, and Ankle-Brachial Index (ABI) was used to determine the severity of arterial insufficiency. NCS was performed to evaluate motor and sensory nerve conduction velocities (NCV), compound motor action potential (CMAP), and sensory nerve action potential (SNAP). Patients with diabetes mellitus were excluded from the study to eliminate confounding factors. The relationship between PVD severity and nerve conduction abnormalities was analyzed statistically.

Results: The study population comprised 24 males and 16 females, with a mean age of 59 years (range: 42-78 years). The distribution of patients according to Fountaine Staging revealed that 32.5% had ischemic rest pain (Stage III), and 7.5% presented with ulceration or gangrene (Stage IV). ABI values indicated that 67.5% of patients experienced claudication pain (ABI: 0.4–0.85), while 7.5% had rest pain (ABI < 0.4). NCS findings demonstrated significantly reduced motor and sensory NCV in advanced PVD stages, with mean values of 40.92 m/s (motor) and 44.88 m/s (sensory). Furthermore, CMAP and SNAP amplitudes were markedly decreased in patients with severe PVD, suggesting ischemic nerve damage.

Conclusion: This study highlights a strong correlation between PVD severity and nerve conduction abnormalities, indicating that ischemic neuropathy plays a critical role in disease progression. Sensory nerve dysfunction was more pronounced than motor involvement, aligning with findings from previous studies. Early detection of nerve conduction deficits in PVD patients may facilitate timely interventions to prevent further neurological complications. Incorporating routine NCS assessments alongside vascular evaluations could improve diagnostic accuracy and patient outcomes in PVD management. Further studies with larger cohorts are recommended to validate these findings and explore potential therapeutic strategies.

ASSESSMENT OF MICRO-SHEAR BOND STRENGTH OF BIODENTINE TO VARIOUS RESTORATIVE MATERIALS AFTER AGING: AN IN - VITRO STUDY

Dr. Sonia Meshram, Dr. Rahul Ramteke — 2025-01-26

Objective: This study aimed to determine the perfect timing for restoratives installations of the micro-shear bond strength (µSBS) of Biodentine with various restorative materials. Materials and Methods: Sixty Biodentine specimens were prepared and categorized into two groups based on aging periods: one week and two weeks. Each group was further divided into three subgroups according to the restorative material used—Short Fiber-Reinforced Composite, Zirconomer, and Cention N—with ten specimens in each subgroup.

Quantitative Culture of Bronchoalveolar Lavage Fluid for the Diagnosis of Bacterial Pneumonia at a Tertiary Care Centre

Chandrahas Kale — 2025-03-31

Background: Pneumonia remains the leading cause of infectious disease mortality globally, necessitating early diagnosis and appropriate antimicrobial management. Bronchoalveolar lavage (BAL) has been established as a crucial diagnostic tool in both immunocompetent and immunocompromised patients, offering advantages over conventional sputum samples by reducing contamination and providing accurate antimicrobial susceptibility data.

Objectives: This study aimed to evaluate the diagnostic yield of quantitative BAL fluid culture in identifying bacterial pathogens responsible for pneumonia and to assess the antimicrobial susceptibility of these pathogens to guide effective treatment.

Methods: Conducted at the Department of Microbiology, Government Medical College, Maharashtra, the study included patients over 18 years undergoing BAL via fiberoptic bronchoscopy for pneumonia diagnosis from June 2018 to May 2019. Quantitative cultures were grown on Blood Agar, MacConkey Agar, and Chocolate Agar, with a positive culture defined at ≥ 10^4 CFU/mL. Pathogen identification and antibiotic susceptibility testing were performed using standard microbiological techniques.

Results: Of the 63 patients studied, 57.14% showed a positive quantitative BAL culture. Staphylococcus aureus was the most frequently isolated pathogen, followed by Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Notably, Methicillin-resistant Staphylococcus aureus (MRSA) constituted a significant portion of S. aureus cases. Gram-negative bacteria showed high resistance to standard antibiotics but were sensitive to Imipenem and Piperacillin-Tazobactam.

Conclusion: Quantitative BAL fluid culture is a valuable diagnostic method for effectively identifying and managing bacterial pneumonia. The procedure not only confirms the pathogen but also informs targeted antibiotic therapy, thereby minimizing the use of broad-spectrum antibiotics and reducing the emergence of resistant bacterial strains.

Cross-Sectional Study of Prevalence and Patterns of Blood Transfusion-Related Complications in A Tertiary Care Hospital

Vaibhav Vilas Deshmukh — 2025-04-03

Background: Blood transfusion is a lifesaving procedure but can lead to various complications, which differ widely in type and frequency. Understanding these complications within the context of a tertiary care setting is crucial for improving patient safety and transfusion practices. Methods: This retrospective cross-sectional study analyzed medical records from 2000 patients who received blood transfusions at a tertiary care hospital over one year. The study focused on identifying the prevalence and patterns of transfusion-related complications, categorized by type and associated with different blood products. Results: The most common complications were allergic reactions and febrile non-hemolytic reactions, reported in 13 and 11 cases respectively, indicating a prevalence with statistically significant p-values of 0.045 and 0.035. Severe complications such as hemolytic reactions, TRALI, and TACO were less frequent, with incidences and p-values of 1 (0.250), 1 (0.650), and 1 (0.800), respectively. The analysis of specific blood products revealed that whole blood transfusions were associated with the highest complication rate (83 cases, p-value 0.020), suggesting a significant risk compared to other blood components. Conclusion: The study highlights that while transfusion-related complications at a tertiary care hospital are mostly mild, severe reactions occur less frequently but remain a concern. The significant association of complications with whole blood underscores the need for careful consideration in its use and calls for continuous monitoring and improvement in transfusion protocols to enhance patient safety.

A Comparative Study of Open Reduction and Internal Fixation (Orif) Vs. External Fixation in Distal Radius Fractures

Rahul Bains — 2025-04-04

Background: Distal radius fractures are among the most common injuries treated in orthopedic practice. The choice between Open Reduction and Internal Fixation (ORIF) and External Fixation often depends on the fracture type, patient factors, and surgeon preference. This study aims to compare the efficacy, functional outcomes, and complication rates of ORIF versus External Fixation in the treatment of distal radius fractures. Methods: A retrospective cohort study was conducted at a single tertiary care center, involving 100 patients with closed distal radius fractures. Patients were divided into two groups based on the treatment received: ORIF (n=50) and External Fixation (n=50). Outcomes measured included functional recovery (assessed by the DASH score), grip strength, wrist mobility, and complication rates. Statistical analysis was performed using t-tests and chi-square tests where appropriate. Results: The ORIF group demonstrated significantly better outcomes in terms of DASH scores (32.9 vs. 27.2, P=0.02) and wrist extension (61.5 degrees vs. 25.1 degrees, P=0.03). Although grip strength and wrist flexion were improved in the ORIF group, these differences were not statistically significant (P=0.12 and P=0.05, respectively). Complication rates were comparable between the two groups, with no significant differences in the rates of infection, nonunion, malunion, or nerve injury. Conclusion: ORIF provides superior functional outcomes compared to External Fixation in the treatment of distal radius fractures, without an increase in complication rates. These findings suggest that ORIF should be considered the preferred method for patients eligible for surgical intervention, taking into account individual patient conditions and surgical expertise.

Cross-Sectional Analysis of Complications in Patients Undergoing Primary vs. Revision Total Knee Arthroplasty

Rahul Bains — 2025-04-04

Background: Total Knee Arthroplasty (TKA) is a common orthopedic procedure aimed at alleviating pain and restoring function in severely arthritic knee joints. With an increasing number of primary TKAs being performed, the number of revision surgeries has also risen. Understanding and comparing the complications associated with primary and revision TKA is crucial for improving surgical outcomes and patient care. Methods: This cross-sectional study analyzed 200 patients who underwent TKA, dividing them into two groups: those receiving primary TKA and those undergoing revision TKA. Data were collected retrospectively from medical records at a single tertiary care center, focusing on demographic information, surgical details, and postoperative complications. Statistical analysis was performed to compare the complication rates between the two groups. Results: The revision TKA group was older (average age 70 years) compared to the primary TKA group (average age 65 years), with a significant difference in age (P<0.05). Complication rates were higher in the revision TKA group, with infection rates at 11% compared to 7.5% in the primary group (P<0.01), mechanical failure rates at 9.5% versus 5.5% (P<0.01), and readmission rates at 15% against 9% (P<0.001). The severity of complications was also greater in the revision group, with a significant increase in moderate and severe complications. Conclusion: Revision TKA is associated with higher and more severe complications compared to primary TKA. These findings underscore the need for tailored perioperative strategies and enhanced patient selection to mitigate the risks associated with revision knee arthroplasty. Future research should focus on longitudinal studies to capture long-term outcomes and further refine surgical and management practices.

Comparison of Radiological Outcomes in Surgical Vs. Non-Surgical Treatment of Acute Achilles Tendon Rupture

Rahul Bains — 2025-04-04

Background: Acute Achilles tendon rupture is a common and significant injury, especially among active individuals. The optimal management—whether surgical or non-surgical—remains a subject of debate. Objective: This study aims to compare the radiological outcomes between surgical and non-surgical treatments for acute Achilles tendon rupture. Methods: A retrospective cohort study was conducted involving 80 patients with acute Achilles tendon ruptures, divided equally between surgical (n=40) and non-surgical (n=40) treatment groups. Radiological outcomes, including tendon gap reduction and tendon integrity, were assessed through imaging techniques. Functional outcomes, healing time, and re-rupture rates were also evaluated. Results: Surgical treatment resulted in significantly better radiological outcomes compared to non-surgical treatment. The surgical group showed greater tendon gap reduction (mean 4.2 mm, SD=1.6) compared to the non-surgical group (mean 2.5 mm, SD=1.3) with a p-value <0.001. Tendon integrity scores were also higher in the surgical group (mean 8.4, SD=0.9) than in the non-surgical group (mean 7.1, SD=1.1), with a p-value of 0.002. Additionally, the surgical group exhibited faster healing times and lower re-rupture rates. Functional recovery scores and range of motion were superior in patients undergoing surgery. Conclusion: Surgical treatment of acute Achilles tendon ruptures is associated with superior radiological outcomes and reduced re-rupture rates compared to non-surgical management. These findings support the use of surgical intervention in suitable patients to optimize tendon healing and functional recovery.

A Comparative Study of Functional Outcomes in Patients with Proximal Femur Fractures Treated with Total Hip Arthroplasty vs. Hemiarthroplasty

Rahul Bains — 2025-04-04

Background: Proximal femur fractures are a common and debilitating injury, particularly among the elderly. The choice between Total Hip Arthroplasty (THA) and Hemiarthroplasty (HA) significantly impacts the patient's functional recovery, mobility, pain management, and overall quality of life. Objectives: This study aims to compare the functional outcomes, postoperative mobility, pain levels, and long-term patient satisfaction between THA and HA in treating proximal femur fractures. Methods: A retrospective cohort study was conducted with a sample size of 120 patients, equally divided between THA and HA groups. The functional outcomes were assessed using the Harris Hip Score and Oxford Hip Score, while mobility was evaluated through Activities of Daily Living (ADL) scores and walking speed. Pain levels were measured using the Visual Analog Scale, and long-term satisfaction was assessed through SF-36 and EQ-5D scores. Statistical significance was determined using t-tests and chi-square tests where appropriate. Results: The THA group showed significantly higher functional scores, including mean Harris Hip Score (82.3 vs. 79.1, p=0.043) and Oxford Hip Score (84.0 vs. 80.2, p=0.043). Mobility assessments also favored THA with higher ADL scores (8.7 vs. 8.0, p=0.017) and faster walking speeds (1.2 m/s vs. 1.0 m/s, p=0.017). Pain levels were lower in the THA group (VAS score: 3.0 vs. 3.7, p=0.029), and reoperation rates were significantly reduced (5.8% vs. 10%, p=0.029). Long-term satisfaction measures were also superior in the THA group (SF-36: 75.0 vs. 70.3, EQ-5D: 0.82 vs. 0.77, both p=0.018). Conclusion: Total Hip Arthroplasty is superior to Hemiarthroplasty in improving functional outcomes, enhancing mobility, reducing pain, and increasing long-term patient satisfaction in the treatment of proximal femur fractures. These findings suggest that THA should be considered the preferred surgical intervention in suitable patients.

The Study of Tadalafil and Tamsulosin as Monotherapy for Lower Urinary Tract Symptoms Due to Benign Hyperplasia of Prostate

Dr Pranal Sahare — 2025-04-04

Introduction: Benign Prostate Hyperplasia (BPH) is the most prevalent benign disease in males with diverse LUTS. It is the fourth most prominent condition among men aged ≥50 years and accounts for 80% of men aged ≥70 years. According to available data, the prevalence of BPH surged from 25% in the 40-49 age group to 80% in the 70-79 age group. Clinically, BPH causes LUTS and its symptoms, such as storage (impaired bladder emptying, urinary frequency, nocturia, urinary urgency, and urge incontinence), voiding (urinary incontinence, a restricted urinary stream), and postmicturition, which can impair patients' quality of life. Materials and methods: We analysed 120 patients of BPH (Benign Prostatic Hyperplasia) with LUTS (Lower Urinary Tract Symptoms) with baseline parameters as international prostate symptom score (IPSS), QMAX (maximum urinary flow velocity), PVR (Post Voidal Residual urine volume), for a period of 12 months. They were divided in to two groups, one group receiving only alpha blockers, other group receiving only PDE -5 inhibitor (Phosphodiesterase type 5 inhibitor/PDE-5I) tadalafil in treatment of LUTS due to BPH. These patients were reviewed at 1, 3, 6 months interval with above mentioned parameters. Results: Of the 120 patients taken up for the study, 60 in each group, only 110 patients completed the study. (54 patients in alpha blockers group and 56 patients in PDE-5 inhibitors group). Both groups were reviewed with mentioned parameters. Conclusion: PDE-5 inhibitor (Tadalafil) should be preferred over alpha blockers in treating LUTS (Lower Urinary Tract Symptoms) due to BPH (Benign Prostatic Hyperplasia) as PDE-5 inhibitors are found to be more efficacious than alpha blocker with lesser incidences of side-effects.

Comparison of Efficacy and Hemodynamic Stability of 0.5 % Isobaric Levobupivacaine and 0.5% Hyperbaric Bupivacaine in Old Age Patients Posted For Lower Limb Surgery under Spinal Anaesthesia

Neepa Patel — 2025-04-04

Background: Spinal anaesthesia, first introduced by August Bier in 1898, has evolved significantly with the introduction of bupivacaine and levobupivacaine. Bupivacaine is the most commonly used local anesthetic, while levobupivacaine and bupivacaine are equivalent but levobupivacaine have fewer cardiac side effects. Isobaric levobupivacaine is less toxicity and is used in various Anesthetic procedures. Geriatric patients are more susceptible to haemodynamic fluctuations due to changes in vertebrae structure, decreased cerebrospinal fluid volume, and nerve degeneration. This study aims to compare the safety profiles of hyperbaric bupivacaine and isobaric levobupivacaine in elderly patients during spinal anaesthesia for lower limb surgery. Materials and methods- The study was conducted at a tertiary health care center over a period of one year and six months, with 110 patients above 60 years of age, either sex, ASA grade III & IV, posted for lower limb surgeries. The total sample size was figured as 110 based on a previous study by Herrera R et al.5 The study involved pre-anaesthetic evaluation, laboratory investigations, and informed consent from all study subjects.The patients were divided into two groups: Group B received a 0.5% 3 ml hyperbaric injection of bupivacaine intrathecally, and Group L received a 0.5% 3 ml isobaric injection of Levobupivacaine intrathecally. The patients were monitored using standard monitors such as pulse oximeter for saturation (SpO2), noninvasive blood pressure monitoring (NIBP), and electrocardiogram (ECG). Sensory and motor assessments were performed immediately after positioning supine and recorded as 0 minutes. The study also assessed the duration of motor blockade, Bradycardia, and hypotension. Postoperatively, hemodynamic parameters, duration of analgesia, and total duration of sensory and motor block were assessed every 2 hourly for 6 hours & 4 hourly till 24 hours. Result- The study compared the heart rate and blood pressure of two groups after spinal anesthesia. Both groups had similar baseline heart rates, but after spinal anesthesia, there was a significant difference in heart rate. Group B had greater pulse rate variability, indicating a statistically significant difference. Systolic blood pressure was comparable in both groups, but the decrease was greater in group B compared to group A. Mean arterial blood pressure was comparable in both groups, but Group B experienced a greater decrease. The onset time of sensory block at T10 level was comparable between groups, but the maximum sensory block level was different. The duration of sensory block was longer in Group B, while the total duration of analgesia was longer in Group B. Group B had greater pulse rate variability, but no significant difference in mean arterial pressure. Conclusion- The study concluded that 0.5% isobaric levobupivacaine is more effective than 0.5% hyperbaric bupivacaine in elderly patients undergoing lower limb surgery due to its superior hemodynamic stability.

Study of Socio Demographic Factors in Women with Stillbirth

Dr. Apurva Tribhuwan — 2025-04-05

Background: To develop preventive strategies, it is crucial to understand the etiology, risk factors, and associated factors leading to stillbirth. The aim of this study was to study the demographic profile of women experiencing stillbirth, to understand the risk factors for stillbirth in low resource settings, and to find the etiology of stillbirth so as to facilitate designing of a stillbirth prevention strategy. Material and Methods: Present study was hospital based, prospective, observational, descriptive study, conducted pregnant women with diagnosed stillbirth (birth weight weighing >500 gm and after 20 weeks of complete gestation) before delivery. Results: In present study, stillbirth rate of 3.99%. We studied 101 cases of stillbirth. Majority pregnant women were from 25-29 years age group (43.56 %) & from 19-24 years age group (32.26 %), were unbooked (60.40 %), were from rural background (58.42 %) & from Lower middle class (56.43 %). In present study, among 101 patients, majority were from para 2 to para 4 group (50.49 %), from 37-40 weeks gestational age (30.69 %) & delivered vaginally (88 %). Previous still birth was noted in 12 cases, among them 2 had history of ≥2 previous still births. Common fetal birth weight group in present study was 2501-3500 grams (26.01 %) & 501-1000 grams (23.76 %). Common maternal risk factors noted were hypertension (24.75 %), maternal obesity (14.85 %), diabetes (9.90 %), & smoking (1.98 %). While fetal growth restriction (11.88 %) & congenital abnormalities (8.91 %) were common fetal high risk factors noted. Conclusion: In still birth cases, majority pregnant women were from 25-29 years age group, were unbooked (60.40 %), were from rural background (58.42 %) & from Lower middle class (56.43 %). Maternal risk factors were identified in 50.4% of cases.

Isolation and Characterization of Hydrocarbon Degrading Bacteria Isolated from Oil Contaminated Soil

Saumya Mishra — 2025-04-05

This study investigates the physico-chemical properties of hydrocarbon-contaminated soil and the potential of isolated bacterial strains to degrade petroleum hydrocarbons. Soil samples were collected from Transport Nagar, Dehradun, and analyzed for pH, electrical conductivity, organic carbon content, moisture, and bulk density, etc. The results indicated significant differences between contaminated and uncontaminated soil properties. Out of 20 isolates, five isolates (DHCS2, DHCS6, DHCS9, DHCS11, and DHCS17) were screened as hydrocarbon degraders by spectrophotometric technique using DCPIP indicator. The percentage of degradation of five isolates were found to be 15.5%, 10.5%, 9.85%, 37.5%, and 15.5% respectively. DHCS11 was found to have highest degradation percentage (37.5%). The isolate DHCS11 was identified as Acromobacter sp., could be a potential candidate for the degradation of polycyclic aromatic hydrocarbons. These findings highlight the importance of microbial bioremediation in restoring contaminated soils.

A Prospective Comparative Study of Hemodynamic Response to Proseal Lma Insertion versus Endotracheal Intubation

Dr.Sudhanshu Sant — 2025-04-05

Introduction: Airway management is a critical skill for anaesthesiologists. The airway can be maintained in a variety of ways, with endotracheal intubation being the gold standard. The use of laryngoscopy and intubation induces an increase in blood pressure and pulse rate. The hemodynamic response to laryngoscopy and tracheal intubation has been extensively documented, and several approaches have been attempted to mitigate it. This response is harmful in patients with a compromised cardiovascular system, especially if it is unregulated. Materials and Methods: A total of 100 patients were randomly selected from the list of elective surgical procedures under general anaesthesia. They were divided randomly by computer generated number method into two groups of 50 patients each. Group ET (n=50):Laryngoscopy and endotracheal intubation with appropriate sized cuffed PVC endotracheal tube was done. Group PLMA (n=50): PLMA size 3 or 4 as appropriate for the patient was inserted and cuff inflated with recommended volume of air. Results: The demographic profile of the patients in Group ETT and Group PLMA were comparable (P>0.05).There was no statistical difference in insertion attempts between endotracheal tube and PLMA. The difference in time required for endotracheal intubation and PLMA insertion was not statistically significant. There was a rise in heart rate and mean arterial pressure (MAP) seen after insertion of both devices, but there was comparatively higher rise seen with endotracheal tube than PLMA and it was statistically significant. Conclusion: From the findings of present study it is concluded that PLMA insertion causes significantly less and transient hemodynamic response in comparison to endotracheal intubation. Hence it could be useful in situations where minimal changes in hemodynamics are desirable. PLMA is also found to be equally safe compared to endotracheal tube, as not a single incidence of aspiration was noted with its use. We recommend routine use of PLMA in place of endotracheal intubation for elective surgical procedures lasting 1 to 2 hours.

The Impact of Maternal Obesity on Labor and Delivery Outcomes: A Comparative Study

Neha U. Chandak — 2025-04-07

Background: Maternal obesity is a recognized risk factor for adverse labor and delivery outcomes. This study aims to compare the labor and delivery outcomes between obese and non-obese pregnant women to better understand the influence of obesity on these processes. Methods: A retrospective comparative study was conducted at a tertiary care hospital, involving a total sample size of 220 women categorized into obese (n=110) and non-obese (n=110) groups based on pre-pregnancy Body Mass Index (BMI). The primary outcomes measured included the duration of labor, rates of epidural anesthesia, spontaneous and assisted vaginal deliveries, labor induction, cesarean sections, and perinatal complications such as gestational diabetes and preeclampsia. Secondary outcomes assessed were postpartum hemorrhage, infection rates, and length of hospital stay. Results: The study found that obese women had a significantly longer average duration of labor (12.4 hours vs. 10.8 hours, p=0.007), higher rates of labor induction (65.5% vs. 48.2%, p=0.013), and cesarean sections (46.4% vs. 34.5%, p=0.038) compared to non-obese women. Additionally, obese women were less likely to have spontaneous vaginal deliveries (50% vs. 63.6%, p=0.028) and more likely to require assisted vaginal deliveries (15.5% vs. 9.1%, p=0.032). Rates of gestational diabetes (26.4% vs. 10.9%, p=0.002) and preeclampsia (20.9% vs. 8.2%, p=0.005) were also significantly higher in the obese group. Furthermore, obese women experienced more postpartum complications such as hemorrhage (12.7% vs. 5.5%, p=0.016) and infections (11.8% vs. 3.6%, p=0.023), and had a longer hospital stay (4.5 days vs. 3.8 days, p=0.011). Conclusion: This study underscores the significant impact of maternal obesity on labor and delivery outcomes, including increased durations of labor, higher intervention rates, and greater perinatal and postpartum complications. These findings highlight the need for targeted prenatal care and intervention strategies to manage obesity-related risks during pregnancy and delivery.

Comparative Efficacy of Atorvastatin and Guggul in LDL-C Reduction: A Randomized Clinical Trial

Lodangi Nagakrishna — 2025-04-07

Hyperlipidemia is a major risk factor for cardiovascular diseases (CVD), necessitating effective lipid-lowering strategies. While atorvastatin remains the first-line treatment for LDL-C reduction, statin intolerance limits its long-term use in some patients. This study aimed to compare the efficacy of atorvastatin and Guggul (Commiphora mukul) in reducing LDL-C levels. A 12-week, randomized controlled trial (RCT) was conducted on 150 patients with hyperlipidemia, divided into atorvastatin (10 mg/day) and Guggul (2000 mg/day) groups. The atorvastatin group exhibited a 26.3% reduction in LDL-C, significantly higher than the 15.3% reduction in the Guggul group (p < 0.001). HDL-C increased by 11.0% and 12.9% in atorvastatin and Guggul groups, respectively, with no significant difference between the two (p = 0.08). While atorvastatin remains superior in LDL-C reduction, Guggul demonstrated moderate lipid-lowering efficacy with a better safety profile, suggesting its potential role as an alternative for statin-intolerant patients.

Detection of Extended Spectrum Beta Lactamases among Gram Negative Bacilli Isolated From Surgical Site Infection in a Tertiary Care Hospital

Chopade Apeksha — 2025-02-06

Background: Surgical site infection (SSI) is a common complication that contribute to significant morbidity and mortality. The common organisms encountered in SSI are Staphylococcus aureus, Enterococci, E.Coli, Klebsiella spp and Pseudomonas. Knowledge of antibiotic susceptibility and drug resistant pattern will be of great help to treating physician and patient. This study is carried out to determine the prevalence of ESBL producing gram negative bacteria associated with SSI. Material & Methods: This is a prospective study carried out in a tertiary care hospital for a period of 2.5 years. 248 cases were diagnosed as having surgical site infection. Pus samples were processed for culture and antibiotic sensitivity. ESBL detection among gram negative bacteria was done by Predictor disk method and AmpC detection was done by AmpC disk test Result: Out of the 248 pus samples 221 were culture positive. Gram negative isolates171 (69.35%) were predominantly isolated as compared to gram positive86 (34.68%). Among the gram negative isolates 133(77.78%) were ESBL producer of which 33.33% were pure ESBL producer, 27.48% isolates shown both ESBL & AmpC production while 16.95% isolates were pure AmpC producer. These isolates were sensitivity to Imipenem & Amikacin. Conclusion: Present study indicated high prevance of ESBL producing bacteria associated with SSI. To prevent such type of infections change of antibiotic prophylaxis, screening for ESBL colonization, better infection control practices should be considered.

Nanoemulsion Formulation for Enhanced Delivery of 5-Fluorauracil and Resveratrol with Advanced Techniques

Mr. Sivakumar Theegala — 2025-04-07

This study focuses on the formulation and optimization of a nanoemulsion-based lipid nanosystem for the dual delivery of 5-fluorouracil (5-FU) and resveratrol (RSV) to enhance dermal drug permeation and therapeutic efficacy. A systematic approach was employed to evaluate excipient screening, lipid selection, emulsifier efficiency, and formulation techniques. Labrasol® (LBR) was identified as the optimal medium-chain oil (MCO) due to its high drug solubility and P-GP inhibitory activity, while Emulcire® 61 WL 2659 (EML) was chosen as the solid lipid for its excellent emulsification properties and stability. Among the various formulation methods tested (S, M, H, K), Method-K, involving double emulsification, demonstrated superior stability, smaller particle sizes, lower polydispersity index (PDI), and higher drug entrapment efficiency (%EE) compared to other methods. Drug-excipient interaction studies using DSC and Fourier-transform infrared spectroscopy (FTIR) confirmed the compatibility and stability of 5-FU and RSV within the optimized formulation. The developed nanoemulsion system exhibited promising potential for dermal drug delivery, with enhanced drug solubility, stability, and bioavailability. These findings provide a strong foundation for further clinical investigations into the use of lipid-based nanosystems for targeted skin cancer therapy. Binary mixture (BM) miscibility studies confirmed LBR and EML as the ideal lipid combination, further optimized using differential scanning calorimetry (DSC) analysis. Tween® 80 emerged as the most effective emulsifier due to its superior emulsification properties and enhancement of membrane fluidity, facilitating drug permeation.

Efficiency of Hospital Information Management Systems: A Comparative Study between Teaching and Non-Teaching Hospitals

Dr D V R Kiran — 2025-04-08

Background: Hospital Information Management Systems (HIMS) are pivotal in enhancing healthcare delivery by improving the efficiency of hospital operations. The effectiveness of these systems may vary significantly between different types of hospitals, influencing various aspects of healthcare management. Objectives: This study aims to compare the efficiency, user satisfaction, and integration of advanced features in HIMS between teaching and non-teaching hospitals. Methods: A cross-sectional study was conducted involving 200 hospitals (100 teaching and 100 non-teaching). The study utilized standardized questionnaires to measure system efficiency, user satisfaction, and the extent of HIMS feature integration. Data analysis included calculating means, standard deviations, and conducting t-tests to compare the performance of HIMS between the two hospital groups. Results: Teaching hospitals demonstrated higher efficiency with a mean score of 80.3 (SD = 5.2) compared to 75.4 (SD = 5.0) in non-teaching hospitals (P < 0.001). Similarly, functionality and user satisfaction were higher in teaching hospitals (Mean = 84.3, SD = 9.6) than in non-teaching hospitals (Mean = 76.1, SD = 9.2), with significant statistical differences (P < 0.001). The integration of advanced features also showed a significant difference, with teaching hospitals scoring higher (Mean = 74.2, SD = 7.2) than non-teaching hospitals (Mean = 64.0, SD = 6.4). Conclusion: The study highlights that teaching hospitals tend to have more efficient, satisfactory, and advanced HIMS compared to non-teaching hospitals. These differences underscore the need for tailored strategies in the implementation and ongoing development of HIMS according to hospital type to maximize technological benefits.

Study of Pathways and Barriers in Accessing Mental Health Services during Coronavirus Pandemic at Pmch Psychiatry Opd

Vivek Pratap Singh — 2025-04-08

Aim: The aim of the present study was to understand the pathways to care among patients with psychiatric illnesses during the COVID 19 pandemic and the barriers to care among patients with psychiatric illnesses (both new and previously diagnosed) during the COVID 19 pandemic. Methods: A cross-sectional, hospital-based, exploratory study was done on patients visiting the OPD of the Department of Psychiatry, Patna Medical College and Hospital, Patna. The study enrolled total of 50 diagnosed cases of new onset psychiatric illness and 50 previously diagnosed cases of psychiatric illness in the Department of Psychiatry at PMCH, Patna, as out-patients was recruited as subjects. Results: In the study population, it was observed that maximum number of patients was in the newly diagnosed cases 18-28 years age group (50%) and previously diagnosed cases 18-28 years, age group (52%). On comparing both groups, significant difference was not found. (P. Value = 0.721). In newly diagnosed cases there were 34 (68%) male and 16 (32%) female and previously diagnosed cases had 32 (64%) male and 18 (36%) female subjects. In the study population, it was observed according to educational qualification maximum number of Illiterate patients were in the newly diagnosed cases18 (36%), Primary 3(6%), High school 5 (10%), Intermediate 14 (28%), Graduate 10 (20%) and previously diagnosed cases Illiterate 20 (40%), Primary 4 (8%), High school 6 (12%), Intermediate 12 (24%), Graduate 8 (16%). On comparing both groups, significant difference was found. (P. Value = 0.011). Conclusion: There was no statistical difference on items in BACE-3 scale. The pathways study found that most of the patients first visited native/ religious faith healers before seeking specialist psychiatric care. This study will help to assess the effect of a stressful event such as COVID 19 pandemic on the difficulties faced in treatment seeking pattern of mental health of the population more so in an already diagnosed case of psychiatric illness.

Impact of Resistance and Endurance Exercise Training on Heart Rate Variability

Dr Rakesh Yeole, Dr Devendra Ghodpage — 2025-04-08

Background: The “Heart rate variability (HRV) test is a non-invasive way to check the hearts and autonomic nervous system (ANS) overall health and performance. The test finds the average and standard deviation of the time between heartbeats. Aim: The goal of this 12-week trial is to find out how different types of exercise, including resistance and endurance training, affect people's HRV. Autonomic control and cardiovascular health will be the primary outcomes of the study.

Wernicke's encephalopathy In a Rural Tertiary Teaching Hospital: A Case Report

Dr.Shaik Fathimunni — 2025-04-11

Background: Wernicke's encephalopathy is a neurologic disorder caused by thiamine (vitamin B1) deficiency, often associated with chronic alcoholism, malnutrition, or other conditions that impair thiamine absorption or utilization. It presents with a classic triad of confusion, ataxia, and ophthalmoplegia, but the full triad is rarely present in all cases.

Case Presentation: We report a case of Wernicke's encephalopathy in a 50-year-old male who presented with acute onset of confusion, unsteady gait, and blurred vision. His medical history was significant for chronic alcohol use and poor dietary intake. He was admitted to our rural tertiary hospital for evaluation and management.

Conclusion: Early recognition and prompt thiamine administration are critical for improving outcomes in patients with Wernicke's encephalopathy, especially in resource-limited settings.

Antibiotic Profile of K. Pneumoniae Isolated from Endotracheal Aspirate in a Tertiary Care Hospital

Dr. Sonia Pradhan — 2025-04-11

Background & Aim: To identify local trends in antibiotic resistance, this study looks at the antibiotic resistance profile of K. pneumoniae isolates from endotracheal aspirates. Materials & methods: 7-month observational research at Hi-Tech Medical College & Hospital, Rourkela, involved 196 samples from ICU patients suspected of ventilator-associated pneumonia. Out of these, 132 were positive. The majority (46.96%) were K. pneumoniae, with a female and male gender distribution. Samples were processed using standard techniques. Identification was done using biochemical assays and automated techniques. Antibiotic susceptibility testing was performed using Kirby-Bauer disk diffusion and VITEK-2. The study examined various antibiotics, including beta-lactams, aminoglycosides, and fluoroquinolones. Results: Out of the 196 tested endotracheal aspirate samples, 132 (48%) were positive for K. pneumoniae, constituting about 62 (46.96%) of the total. Other organisms comprised 41 (31.06%), and others comprised 29 (21.96%). Most patients were male (58.06%), with an average age of 55 years. Patients with prolonged ICU stays (>10 days) accounted for most isolates. 10 (16.39%) were sensitive to gentamicin (n=61), and 12 (19.3%) were sensitive to amikacin (n=62). Conclusion: According to the study, K. pneumoniae in endotracheal aspirates from intensive care unit patients is growing more resistant to antibiotics. This suggests that urgent action is required, including prudent antibiotic usage, strong infection control, and ongoing resistance monitoring.

Comparative Outcomes of Volar Locking Plate Fixation versus External Fixation in Unstable Distal Radius Fractures

Dr.Vinay B Patil — 2025-04-14

Background: Distal radius fractures that present instability frequently occur in orthopedic cases while requiring extensive clinical and economic resources for treatment. Doctors currently use two standard techniques for surgical stabilization because they involve volar locking plate fixation or external fixation. The field of implant development has made considerable progress while ongoing discussions continue on finding the most favorable method regarding fracture correction while minimizing complications. The goal of this research was to evaluate both radiological and functional results alongside adverse event occurrence when determining the effectiveness of volar locking plate fixation against external fixation for unstable distal radius fracture treatment. Methods: on this prospective comparative take a look at, 100 sufferers with unstable distal radius fractures have been randomized into two treatment groups: volar locking plate fixation (n = 50) and external fixation (n = 50). Radiographic parameters were measured preoperatively and at 6 weeks, 3 months, and six months postoperatively. useful consequences have been evaluated the use of the Disabilities of the Arm, Shoulder and Hand (dash) rating and grip strength assessments. headaches along with infection, lack of reduction, and hardware-associated troubles had been systematically recorded. Results: sufferers in the volar locking plate group established notably higher healing of radial height and volar tilt at 3 and six months (p < zero.05). Their practical results, measured via dash rankings and grip strength, had been notably advanced (p < zero.05) as compared to the external fixation organization. although each strategies yielded ideal scientific effects, outside fixation changed into related to a better occurrence of pin tract infections and not on time recuperation of wrist feature. Conclusion: Volar locking plate fixation supplied a more favorable radiological and practical healing profile in unstable distal radius fractures, with fewer headaches than outside fixation. nonetheless, outside fixation stays a possible alternative in unique situations, specifically in which inner fixation is contraindicated. in addition massive-scale, long-term research are warranted to refine treatment algorithms and optimize patient care.

A Comparative Interventional Study of Effects of Silicon Oil on Peripapillary Capillary Perfusion in Patients with Rhegmatogenous Retinal Detachmentat Sms Hospital

Dr Nagendra Shekhawat — 2025-04-15

Background: Rhegmatogenous retinal detachment (RRD) is a vision-threatening condition often managed by pars plana vitrectomy (PPV) and silicone oil (SO) tamponade. While SO stabilizes the retina and facilitates reattachment, its impact on retinal microvasculature, particularly peripapillary capillary perfusion, remains under investigation. Optical Coherence Tomography Angiography (OCTA) enables detailed visualization of these vascular changes. This study evaluates the effects of SO tamponade and subsequent silicone oil removal (SOR) on peripapillary capillary perfusion in RRD patients.

Methods: This prospective, interventional, comparative study included 112 eyes with unilateral RRD undergoing PPV and SO tamponade. Patients were examined pre-SOR and at 1 week, 1 month, and 3 months post-SOR. OCT Angiography (4.5×4.5 mm² scans) assessed peripapillary capillary perfusion globally and by sectors (superior and inferior). Best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were also recorded. Statistical significance was set at p<0.05.

Results: The global peripapillary perfusion improved from 42.266±0.913 pre-SOR to 42.870±0.884 at 3 months post-SOR (p<0.001). Superior and inferior perfusion segments showed similar progressive increases. BCVA improved significantly post-SOR (pre-SOR mean: 0.815±0.335 logMAR; post-SOR: 0.371±0.243; p<0.001). IOP normalized after SOR (pre: 18.670±2.002 mmHg; post: 12.348±3.382 mmHg; p<0.001). Each follow-up interval demonstrated statistically significant improvement compared to baseline and previous time points.

Conclusion: Silicon Oil tamponade transiently reduces peripapillary capillary perfusion. Following SOR, peripapillary perfusion progressively recovers, accompanied by improved BCVA and normalized IOP. OCTA offers valuable insights into the microvascular dynamics and recovery following SO removal, guiding postoperative management and timing of SOR. Further studies should explore long-term vascular and functional outcomes to refine clinical decision-making for RRD management.

The Role of Mca/Ua Pulsatility Index Ratio in Managing Preeclampsia and Gestational Hypertension: A Prospective Study

Dr. T. Shireesha — 2025-04-15

Background: Preeclampsia and gestational hypertension pose significant risks to both mother and fetus. The middle cerebral artery to umbilical artery (MCA/UA) pulsatility index ratio may serve as a valuable tool in predicting and managing adverse outcomes. Methods: In a prospective observational study, 200 pregnant women with preeclampsia or gestational hypertension were assessed using Doppler ultrasound to determine the MCA/UA PI ratio. Participants were grouped into cases (ratio ≤1) and controls (ratio >1). Maternal and neonatal outcomes were analyzed. Results: The study found that 52 women (26%) had an MCA/UA PI ratio ≤1. These cases had a higher progression to severe preeclampsia and eclampsia (p<0.00001), increased incidence of severe oligohydramnios (p<0.0001), and higher rates of emergency cesarean sections (p=0.00027). Neonatal complications, including low birth weight, low Apgar scores, and NICU admissions, were significantly higher in cases. Conclusion: The MCA/UA PI ratio is a significant predictor of both maternal and neonatal adverse outcomes in preeclampsia and gestational hypertension. Utilizing this ratio can enhance clinical decision-making and improve management strategies.

The Predictive Value of Mca/Ua Pulsatility Index Ratio in Adverse Perinatal Outcomes among Women with Preeclampsia and Gestational Hypertension

Dr. T. Shireesha — 2025-04-15

Background: Preeclampsia and gestational hypertension are significant causes of maternal and fetal morbidity and mortality worldwide. The middle cerebral artery to umbilical artery (MCA/UA) pulsatility index ratio has emerged as a potential predictor of adverse perinatal outcomes in these conditions. Methods: A prospective observational case-control study was conducted on 200 pregnant women diagnosed with preeclampsia or gestational hypertension after 30 weeks of gestation. Doppler ultrasound was used to measure the MCA/UA pulsatility index ratio. Women with a ratio ≤1 were categorized as cases, and those with a ratio >1 as controls. Adverse perinatal outcomes were recorded and analyzed. Results: Of the 200 women, 52 (26%) had an MCA/UA ratio ≤1. The cases showed a significantly higher incidence of severe oligohydramnios (26.9% vs. 6.7%, p<0.0001), emergency cesarean sections (71.15% vs. 37.16%, p=0.00027), low birth weight (<2.5 kg) infants (59.61% vs. 25.67%, p<0.00001), and NICU admissions (68.62% vs. 30.55%, p<0.00001). The MCA/UA ratio demonstrated a sensitivity of 39.04% and specificity of 88.40% in predicting adverse perinatal outcomes. Conclusion: An abnormal MCA/UA pulsatility index ratio (≤1) is significantly associated with adverse perinatal outcomes in women with preeclampsia and gestational hypertension. Routine use of this Doppler parameter can aid in early identification and management of at-risk pregnancies.

LARYNGEAL SIGNS AND SYMPTOMS AND GASTROESOPHAGEAL REFLUX DISEASE (GERD): A CRITICAL ASSESSMENT OF CAUSE AND EFFECT ASSOCIATION

Dr Jiyaul Haque Ansari, Dr. A.K. Singh — 2025-04-08

Background:
Laryngeal symptoms such as hoarseness, throat clearing, chronic cough, and globus sensation are frequently encountered in clinical practice and are often attributed to gastroesophageal reflux disease (GERD). However, the strength of the causal relationship between GERD and these laryngeal manifestations remains a subject of debate.

The Role of the Microbiome in Endodontic Treatment Failure

Dr Saneyah Amanat — 2025-04-16

Background: Endodontic treatment failure remains a significant clinical challenge, often attributed to persistent or recurrent microbial infections within the root canal system. The complexity of the root canal microbiome, including its diversity and resistance mechanisms, is increasingly recognized as a critical factor influencing treatment outcomes. However, the specific microbial signatures and their correlation with clinical failure remain underexplored. Objective: This study aimed to investigate the microbial composition of endodontically treated teeth with persistent apical infections and to compare microbial diversity, abundance, and resistance profiles between treatment failure and successful outcome groups. The objective was to determine the role of the microbiome in contributing to post-treatment disease and resistance to conventional therapies. Methods: A prospective, cross-sectional study was conducted on 120 adult patients aged 18–65 years who had undergone non-surgical root canal therapy within the past six months. Sixty patients exhibited post-treatment apical periodontitis and persistent symptoms, while 60 age- and tooth-matched patients with successful treatment outcomes served as controls. Clinical evaluations, including symptom severity, radiographic lesions, and oral hygiene status, were recorded. Root canal samples were collected aseptically and analyzed using 16S rRNA gene sequencing and metagenomic shotgun sequencing. Bioinformatics tools (QIIME 2, MetaPhlAn) were used to assess alpha and beta diversity, species identification, and functional pathways. Statistical analyses included t-tests, chi-square, PCA, and multiple regression with significance set at p<0.05. Results: The treatment failure group demonstrated significantly higher alpha diversity (Shannon Index: 3.8 ± 0.5 vs. 2.5 ± 0.4; p=0.001), indicating a richer and more diverse microbial community. Dominant species in the failure group included Enterococcus faecalis (70%), Fusobacterium nucleatum (65%), Porphyromonas gingivalis (60%), and Candida albicans (30%). These microorganisms exhibited strong biofilm-forming abilities and resistance to common antibiotics such as vancomycin, tetracycline, and metronidazole. Positive correlations were found between microbial diversity and both symptom severity (r=0.65, p=0.01) and lesion size (r=0.70, p=0.01), while a negative correlation was observed with oral hygiene status (r=−0.50, p=0.01). Conclusion: The findings highlight the critical role of a diverse and resistant root canal microbiome in endodontic treatment failure. The prevalence of biofilm-forming and antibiotic-resistant species in failed cases underscores the limitations of conventional antimicrobial therapies. Future endodontic strategies should incorporate microbiome-informed diagnostic tools and tailored therapeutic approaches to improve treatment success and long-term outcomes.

Comparison of Vaginal Versus Cesarean Delivery in Women with Previous Cesarean: A Cross-Sectional Study on Maternal and Neonatal Outcomes

Vishwanath Dange — 2025-04-16

Background: The decision between attempting a vaginal birth after cesarean (VBAC) and opting for a repeat cesarean delivery (RCD) can significantly impact maternal and neonatal outcomes. This study aims to compare the outcomes associated with these delivery options in women with one previous cesarean. Methods: This cross-sectional study involved 200 women with a history of one previous cesarean section who were delivering at a tertiary care center. Participants were grouped based on their delivery method: vaginal delivery (n=92) or cesarean delivery (n=108). Data were collected on maternal length of hospital stay, neonatal ICU admissions, postpartum hemorrhage, and Apgar scores at 5 minutes. Statistical analyses included t-tests, chi-square, and Fisher's exact tests, as appropriate. Results: The study found that women who underwent vaginal delivery had significantly shorter hospital stays (mean 3.2 ± 1.1 days) compared to those who had a cesarean delivery (mean 4.8 ± 1.4 days; p < 0.001). Neonatal ICU admission rates were lower in the vaginal delivery group (6.5%) compared to the cesarean delivery group (13%; p = 0.045). However, there was no significant difference in the rates of postpartum hemorrhage between the two groups (p = 0.21). Neonates born via vaginal delivery had significantly higher Apgar scores at 5 minutes (mean 9.4 ± 0.6) compared to those born via cesarean delivery (mean 9.1 ± 0.7; p = 0.032) Conclusions: Vaginal delivery in women with a previous cesarean section is associated with shorter hospital stays and potentially better neonatal outcomes in terms of Apgar scores and reduced ICU admissions. These findings support the consideration of VBAC in eligible women but underscore the importance of individualized clinical decision-making based on comprehensive risk assessments.

Clinico-Epidemiological Study of Management of Blunt Trauma Chest in a Tertiary Center

Dr.G.Kiran — 2025-04-17

Introduction: Blunt chest trauma denotes injuries to the chest resulting from forceful impact in the absence of penetration, such as those sustained from a blow, fall, or collision. Chest trauma is the leading cause of death from physical trauma after head and spinal cord injury. Thoracic injuries are primary or a contributing cause of about one- fourth of all trauma-related deaths. The mortality rate in these cases is about 10%. Thoracic injuries account approximately 20–25% of deaths due to trauma. 16,000 deaths occur per year in India alone as a result of chest trauma. Objective: To understand the epidemiological profile of patients reporting to the trauma center of our hospital with blunt thoracic trauma and to ascertain the impact of various etiologies of blunt chest trauma. Materials and methods: Between January 2023 and April 2024, consecutive patients with blunt thoracic trauma, who presented to the emergency department at Rangaraya Medical College (Kakinada, Andhra pradesh, India), were reviewed in this retrospective study. Data collected regarding common injury modes, age and gender distribution, pre-hospitalization practices, clinical presentations, associated injuries, severity of injuries, and management options from the hospital record section and these data were analyzed with descriptive statistics. Results: Majority of the patients were males who were involved in RTA. Presentation was mostly in the form of rib fractures, hemothorax, pneumothorax and flail chest. Most of the patients could be managed conservatively or by inserting an ICD tube and supportive treatment. None required an operative intervention. Mortality was mostly seen only when other systems were involved (CNS, abdominal organs, long bone fractures, spine injuries). Conclusion: Chest injury is seen commonly in RTA patients. Most of the patients of chest injuries can be managed by symptomatic care and simple life-saving intervention, i.e. intercostal drainage. CT chest is better than chest x-ray in early identification of pneumothorax and must be done if available. With increased RTAs, it is needed to have public awareness regarding road safety measures and educating them about the first aid measures for trauma patients.

Dual Plating Fixation for Schatzker Type V And VI Tibial Plateau Fractures: A Prospective Analysis of 30 Cases Assessed with the Modified Rasmussen Criteria

Dr Rishabh Goyal — 2025-04-18

Background: Bicondylar (Schatzker V–VI) tibial plateau fractures pose a demanding reconstructive challenge because axial–varus/valgus forces destroy both columns and jeopardise soft tissues. Although dual plating has become popular, high quality prospective data from the Indian sub continent remain sparse. Methods: Between July 2022 and December 2023 we prospectively enrolled 30 consecutive adults (mean age 37.9 ± 9.4 years; 83 % men) with closed Schatzker V (n = 19) or VI (n = 11) fractures treated at a level I trauma centre. A standardised protocol was followed: anterolateral rafting 3.5/4.5 mm locking plate plus posteromedial antiglide/buttress plate through dual approaches, elevation of depressed segments, autograft or synthetic bone substitute as required, and early mobilisation. Functional and radiological outcomes were evaluated at 6 months with the Modified Rasmussen score; complications were recorded. Results: Mean surgical delay was 5.8 days (2–12). All fractures united (mean 19.7 weeks). The mean functional score was 27.4 ± 2.8; 15 (50 %) results were excellent, 13 (43 %) good and 2 (7 %) fair. Radiological scores paralleled clinical findings (excellent = 15, good = 9, fair = 4, poor = 2). Knee range of motion averaged 0–118°. Complications comprised knee stiffness (5 patients), medial column collapse (2), superficial infection (2) and one wound dehiscence; no non unions, neurovascular injuries or deep infections occurred. Conclusion: Anatomical dual column plating delivered reliable union, restoration of alignment and predominantly excellent to good functional results in complex bicondylar fractures, with an acceptable, mostly avoidable complication profile. Early soft tissue–respecting fixation, meticulous posteromedial buttressing and regimented rehabilitation appear pivotal.

A Case Report On Carcinoma of the Left Maxillary Sinus in an Elderly Patient

Dr Rajshekhar C Jaka — 2025-04-18

Background: Maxillary sinus carcinoma is a relatively rare head and neck cancer malignancy but frequently appears in the advanced setting owing to initially non-specific symptoms. Tumors in this area can extend into the nasal cavity, oral cavity, orbit, and adjacent bony structures, often causing diagnostic and therapeutic difficulties. Case Presentation: We report the case of an 81-year-old woman who presented with progressive left-sided nasal blockage, episodic epistaxis, and ill-defined left midfacial swelling. MRI and PET-CT scan were found to reveal a heterogeneous soft-tissue mass originating from the left maxillary sinus with intranasal extension and erosions in the multiple bony walls. Histopathological assessment of biopsy tissues revealed a microcystic patterned malignant tumor; immunohistochemistry was recommended for further categorizing the neoplasm to conclusion. Conclusion: This case highlights the value of a high index of suspicion and thorough diagnostic imaging in the identification of malignant pathologies of the maxillary sinus. Surgical excision with adjunctive therapy is still the cornerstone of treatment, but care needs to be individualized according to tumor type, extent, and patient circumstances. This case contributes to the literature detailing the wide ranging presentations and therapeutic paradigms of maxillary sinus carcinoma, highlighting the importance of multidisciplinary management and early diagnosis.

Buccal Lymphoma: A Case Report

Dr Rajshekhar C Jaka — 2025-04-19

Background Non-Hodgkin’s Lymphoma (NHL) encompasses a diverse group of lymphoid malignancies with varied histopathological and clinical features. Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of NHL, accounting for approximately 30–40% of adult cases. Although primarily arising in lymph nodes, extranodal presentations—especially in the oral cavity—are not uncommon. Oral lymphomas can mimic other neoplastic or inflammatory lesions, leading to potential delays in diagnosis. Case Presentation We report the case of a 41-year-old female patient with a painless swelling on the left side of her face and an associated oral ulceration over the buccal mucosa. She had poorly controlled diabetes mellitus but no significant history of weight loss, fever, or night sweats. Imaging showed a lobulated, heterogeneously enhancing soft-tissue lesion invading the left alveolar ridge and mandibular region. Biopsy of the buccal mucosa revealed large atypical lymphoid cells positive for CD20, PAX5, BCL-6, and CD10, with a Ki-67 proliferative index of ~98%, consistent with Diffuse Large B-Cell Lymphoma (DLBCL), germinal center subtype. The patient underwent six cycles of R-CHOP chemotherapy with significant metabolic remission observed on interim PET-CT scans. She also received prophylactic high-dose methotrexate to minimize CNS involvement. The patient responded well to therapy and was discharged on maintenance follow-up. Conclusion This case highlights an unusual primary presentation of DLBCL in the buccal mucosa. Extranodal lymphomas of the head and neck region can be diagnostically challenging given their broad differential diagnoses. A multidisciplinary approach—encompassing otolaryngology, maxillofacial surgery, oncology, pathology, and radiology—is essential for timely diagnosis. Aggressive regimens such as R-CHOP, with CNS prophylaxis when indicated, can yield favorable outcomes. Early recognition of oral lymphomas is particularly critical in immunocompromised or poorly controlled diabetic patients.

Clinicopathological Study of Skin Adnexal Tumours at Tertiary Care Centre

Dr. Chandrashekhar P. Bhale — 2025-04-19

Background: Skin, which is composed of epidermis, dermis and skin adnexa has high incidence of Skin tumours. Subgroups of skin adnexal neoplasms are distinguished based on the differentiation of these tumours towards sebaceous, apocrine, eccrine, and hair follicles. Though clinical features provide clues to the diagnosis, histopathology remains the gold standard in the confirmation of the diagnosis. Categorization of the tumor as benign or malignant is vital for therapeutic and prognostic purposes. Present study was conducted to assess frequency, histological subtype, benign or malignant nature and age distribution of skin adnexal tumours which will further help diagnosis towards their line of differentiation. Materials and Methods: Present study is a cross sectional observation study conducted from October 2022 to September 2024. 43 cases of skin adnexal tumors of all ages & both gender who has been advised histopathology were enrolled. After Histo-morphological analysis of the tumors they were classified according to predominant pattern of differentiation into follicular, sebaceous, eccrine, and apocrine. Statistical analysis was performed using SPSS software, version 20. Observations and Results: majority cases i.e. 17 (39 %) were from age group between 41 to 60 years. Males were 24 (56 %) and females were 19 (44 %). In majority i.e. 28 (65 %) Head, neck & face was involved. Benign cases were 40 (94 %) whereas Malignant were 3 (6 %). In 26 (61 %) cases Hair follicle was involved. In 4 (10 %) Sebaceous gland, in 6 (13 %) Apocrine gland and in 7 (16 %) Eccrine gland was involved. amongst Benign cases Trichelemmal cyst was the commonest found in 12 (29 %) cases. Conclusion: To conclude Majority of the skin adnexal tumours were benign compared to malignant. Head, neck and face region were found as the commonest site of involvement and maximum cases involved hair follicle

A Comparative Study of Efficacy and Safety of Oral Contraceptive Pills versus Intrauterine Devices in Preventing Unintended Pregnancy

Vishwanath Dange — 2025-04-19

Background: Unintended pregnancy remains a significant public health challenge worldwide, influencing the socio-economic and health outcomes for women. Oral Contraceptive Pills (OCPs) and Intrauterine Devices (IUDs) are widely used for contraception, but their comparative efficacy and safety have not been consistently evaluated across diverse populations. Objectives: This study aimed to compare the efficacy and safety of OCPs versus IUDs in preventing unintended pregnancies. Methods: A prospective observational cohort study was conducted involving 120 participants who were recruited from a family planning clinic and chose either OCPs or IUDs based on preference and medical suitability. The primary outcome measured was the rate of unintended pregnancies. Secondary outcomes included method continuation rates, user satisfaction, and the incidence of side effects. Data were analyzed using Chi-square tests, Fisher’s exact test, and Z-tests to compare proportions between the two groups. Results: The incidence of unintended pregnancies was significantly lower in the IUD group (1.7%) compared to the OCP group (6.7%), with a p-value of 0.037. Continuation rates were higher for IUD users (98.3%) than for OCP users (93.3%), with a significant difference (p-value = 0.045). The IUD group also reported fewer side effects and higher overall satisfaction. Safety profiles indicated fewer adverse effects among IUD users compared to those on OCPs. Conclusion: IUDs were found to be more effective and safer than OCPs in preventing unintended pregnancies. They also had higher user satisfaction and continuation rates. These findings support the use of IUDs as a preferable method of contraception for women seeking long-term prevention of unintended pregnancy. Limitations: The study’s limitations include its reliance on self-reported data, the non-randomized design, and the limited sample size and diversity which may affect the generalizability of the findings.

Evaluating the Clinical Outcomes of Total Hip Arthroplasty Utilizing Dual Mobility Implants: A Comprehensive Review

Sajjad Hussain Bhatti — 2025-04-19

Objective This study set out to evaluate the clinical results of total hip arthroplasty (THA) with a dual mobility implant (DMI). Study design: A prospective cohort study Place and Duration: This study was done at, Pir Abdul Qadir Shah Jillani Institute of Medical Sciences GIMS Gambat Khairpur mir’s for period of one years from March 2024 to March 2025. Methodology Total 30 patients participated for this study. The patients were both male and female. The age bracket was from 32 years to 75 years. There were several reasons for which these patients were on the list of THA. Patients were assessed clinically and a radiograph of each patient was taken before the surgery. A DMI was used in the surgery. Patients were asked to attend their follow-up visit after three months of the surgery. This visit was arranged to check if there is any sign of dislocation. Results The ratio of male patients to female patients was 1.5:1. There were 18 (60%) male patients and 12 (40%) female patients. The average age of the patients was 60.21 ± 9.25 years. Harris Hip Score (HHS) of the patients was recorded before the surgery and an average of HHS was 47.70 ± 6.85. It improved after the surgery and was seen to be 85.25 ± 7.29 (p < 0.001). No patient was diagnosed with dislocation on the three months follow up visit. Conclusion The results of the study demonstrate that there was a significant improvement in the HHS of the patients treated by THA using a DMI and there was no dislocations observed after the surgery.

To Assess the Outcomes of Total Hip Arthroplasty Using Dual Mobility Implants

Waseem Ahmed — 2025-04-19

Background: A common and reasonably priced treatment, total hip arthroplasty (THA) is well-known for its positive results in treating advanced hip osteoarthritis and associated disorders. Although there has been a 9.2% revision rate in Pakistan due to cup shell fractures, dual mobility implants, which are being utilised more and more to lower the risk of dislocation, have shown promise. Objective: To assess the outcomes of total hip arthroplasty using dual mobility implants. Study design: Descriptive study Place and Duration: This study was conducted in, Muhammad Medical College, Ibn-e-Sina University Hospital Mirpurkhas Pakistan from January 2022 to January 2025 Methodology: 80 patients who had total hip arthroplasty (THA) with dual mobility implants participated in this descriptive study, which was carried out at the Department of Orthopaedic Surgery. Clinical evaluations and Harris Hip Scores were used to evaluate pre- and postoperative results, and SPSS version 28.0 was used to analyse the data. With a paired t-test and dependent stratified t-test by gender, we established statistical significance at p < 0.05. Results: The total number of patients was 80, aged 61.05 years on average, with 65% of them being male. The most common reason for performing THA was avascular necrosis of the femoral head. Surgical dislocations were not encountered and both sexes’ Harris Hip Scores improved (p < 0.001) statistically. Conclusion: The study found that there was a statistically significant difference in preoperative and postoperative evaluations of the Harris Hip Score. Moreover, no dislocations were observed after dual mobility total hip replacement.

Outcomes of Cyclogest Pessary versus Conservative Treatment in Managing Threatened Miscarriage: A Comparative Analysis

Sanna Khan — 2025-04-19

Objective: This study aims to compare the effectiveness of Cyclogest pessary against conservative management in women experiencing Potential miscarriage or also referred to as threatened abortion, focusing on pregnancy continuation, maternal health outcomes, and neonatal results. Study design: A prospective cohort study Place and Duration: This study was conducted in, District Headquarter Hospital Mirpurkhas Pakistan from March 2024 to March 2025 Methodology: A prospective cohort design was employed. Participants were assigned to two groups based on the clinical management approach: The Cyclogest Group (n=100), which received a daily 400 mg dose of vaginal progesterone (Cyclogest pessary) until 20 weeks of pregnancy or symptom resolution; and the Conservative Management Group (n=70), where participants received alternate forms of progesterone (oral or intramuscular) for similar therapeutic purposes. The data was analyzed using the SPSS version 25, and the statistical significance was defined as p ≤ 0.05 and the software used descriptive statistics which set the baseline characteristics. Results: The average age for the Cyclogest group was 28.2 ± 5.1 years, and for the conservative group, it was 27.5 ± 5.4 years (p = 0.27). Both groups were similar in terms of gravidity, parity, and gestational age at the time of initial presentation (p > 0.05). Pregnancy continuation in the past 20 weeks was notably higher in the Cyclogest group (85%) compared to the conservative management group (75%), with a p-value of 0.005. The incidence of complete miscarriage was also lower in the Cyclogest group (12%) compared to the conservative group (28%). Maternal complications such as postpartum hemorrhage, infections, and hypertensive disorders showed no statistically significant differences between the two groups (p > 0.05). Conclusion: The use of Cyclogest pessary significantly enhances pregnancy continuation rates in women with Potential miscarriage or also referred to as threatened abortion compared to conservative management. Further randomized controlled trials are necessary to confirm these findings and refine clinical guidelines for treatment.

Impact of Digital Transformation on Healthcare Accessibility in Saudi Arabia: A Systematic Review

Mohammed Majed Alsahmah — 2025-04-21

Introduction: Digital transformation is reshaping healthcare accessibility in Saudi Arabia, aligning with the Vision 2030 initiative to establish a sustainable and efficient healthcare system. Advances in telemedicine, electronic health records (EHRs), and AI-driven diagnostics offer new solutions to overcoming traditional barriers to care. Objectives: This systematic review examines how digital health technologies improve healthcare accessibility in Saudi Arabia. It explores their role in reducing geographical and time-related barriers while identifying key implementation challenges. Methods: A systematic review of peer-reviewed literature (2020–2024) was conducted using databases such as PubMed, Google Scholar, and the Saudi Digital Library. Studies assessing the impact of digital health technologies on healthcare accessibility in Saudi Arabia were included. The PICO framework guided the review, and quality was assessed using the Joanna Briggs Institute (JBI) checklist. Results: The review identified telemedicine and AI-assisted diagnostics as key drivers of improved healthcare access, particularly in rural areas. Studies reported up to a 40% reduction in consultation wait times and enhanced continuity of care due to digital records integration. However, barriers such as the digital divide, infrastructure limitations, and privacy concerns persist, hindering full-scale adoption. Conclusion: Digital health technologies significantly enhance healthcare accessibility in Saudi Arabia, supporting the goals of Vision 2030. However, targeted efforts are required to bridge digital literacy gaps, improve infrastructure, and strengthen data protection frameworks. Future research should focus on long-term digital health adoption and patient-centered outcomes to maximize the benefits of digital transformation in healthcare.

The Use of a Narrow Implant with Edentulous Patients: A Systematic Review

Sultan A. Alqahtani — 2025-04-21

Background: Implant selection has been highly emphasized in fully edentulous patients, where using slender diameter implants has become a central area of interest in dental implantology, mainly where patients have limited bone width and height. New developments in implant technology have demonstrated that these implants are as effective as broader implants and may be used for tooth replacement. Objectives: This systematically planned and executed article aims to discuss the difficulties involving complications in completely edentulous patients along with the success and failure rates of narrow diameter implants. Methods: Electronic databases, including but not limited to MEDLINE and Google Scholar, were searched for articles with standard protocol as per the “PRISMA guidelines”. The criteria for paper selection involved articles between 2020 and 2024, limited to peer-reviewed sources that dealt with the use of implants with lesser diameter in edentulous individuals. Nine papers were chosen from the initial search's 2035 results based on specific inclusion criteria. Results: The analysis shows a high overall long-term success rate of small-diameter implants (SDIs), ranging from 94.6% to 100%, with minimal marginal bone loss. Studies report cumulative survival rates such as 99.4% at a two-year follow-up and 97.7% over 55 months. Marginal bone loss was low, with some studies showing mean values of 0.15 mm after 24 months and 0.14 ± 0.39 mm following functional loading over 1–4 years. Additionally, patient satisfaction was high, with some studies reporting that 99% of patients maintained good soft tissue health, and prosthetic survival rates reached 100%. The literature confirms that narrow implants are a viable solution for ridge resorption and for use in medically compromised patients. Conclusion: With much higher survival rates than conventional, large implants, small-diameter implants are a good and safe option for edentulous patients undergoing prosthetic rehabilitation. This review adds knowledge to the current debate about the appropriate approaches to dental implantology, discussing how thin implants can be used in treatment and possible drawbacks.

Safety and Efficacy of Travoprost (0.004%) Versus Timolol (0.5%) In Patients with Open Angle Glaucoma or Ocular Hypertension: A Randomized Prospective Double-Blind Study

Prasheeta V Praviraj — 2025-04-22

Background: The ultimate goal of pharmacotherapy in glaucoma is to reduce the IOP. The current study is designed to audit the efficacy and safety of 0.004% travoprost over 0.5% timolol eye drops for the treatment of primary open angle glaucoma or ocular hypertension and to suggest appropriate intervention for the treatment of the disease. Methods: A prospective, randomised, double blind, parallel group clinical study was conducted among adult patients aged 18 years and above of either gender, any ethnicity clinically diagnosed with primary open angle glaucoma or ocular hypertension without any recognizable secondary causes. 60 patients were randomly assigned in double blind fashion to the treatment groups (30 were in group A intervention other 30 were in Group B intervention). Efficacy and safety were assessed on periodic follow-up visits. Results: There was no significant difference observed between the two groups in the first two weeks of follow up i.e. 2nd and 6th week. But by 9th week onwards statistically significant difference was observed. On 12th week difference was extremely statistically significant. Timolol group showed more of eye irritation (23.33%) followed by red eye in only 2 patients (6.67%). The Group B (Travoprost) patients showed eye irritation (40.7%), red eye (29.6%), Iris pigmentation (3.7%), eyelash growth (14.8%), periorbital pigmentation (3.7%). Conclusion: Travoprost 0.004% eye drops once daily lowers the intra-ocular pressure significantly more than Timolol 0.5% eye drops twice daily. Though timolol has shown better tolerability, both travoprost and timolol were well tolerated and safe for use in patients with open angle glaucoma.

A Retrospective Study of Clinical Spectrum and Treatment Outcomes of Hiv Associated Cancers In A Tertiary Care Centre

Dr. T. Rethinesh Kumar — 2025-04-23

Introduction: With the introduction and widespread availability of highly active anti-retroviral therapy (HAART), the landscape of HIV/AIDS has changed considerably. This is true for HIV-associated malignancies as well. Post-HAART, the incidence of Kaposi's sarcoma and central nervous system (CNS) lymphoma (among AIDS-defining cancers) decreased in parallel with AIDS-defining infections. On the other hand, the incidence of systemic non-Hodgkin's lymphoma (NHL) and cervical cancer decreased less than others and remains higher in HIV-infected patients than in the general population. Materials and methods: The study was a retrospective observational study which included all the patients with HIV and cancer attending the Oncology Department OPD Department of Radiation Oncology, Government Madurai Medical College, Madurai between January 2024 and December 2024. Data obtained from the case records was used to fill up the proforma which included the patient factors (Age, sex, performance status, BMI, substance abuse), HIV related parameters (Time since diagnosis of HIV, baseline CD4 counts, comorbid conditions, treatment with HAART), tumour related factors (Site, type of cancer, subtype, stage, prognostic factors depending on the histology) and treatment aspects (Type of treatment, any requirement of dose modifications, toxicity, response, compliance). Results: The study included 200 patients with HIV and cancer (86 female patients and 114 male patients) with an average age of 42 years. A majority of the patients (39%) were in the 31-40 years age group. The mean BMI of the study group was 19.45 (Range: 10 -26.5). 59 of the 200 patients (29.5 %) had poor general condition with a performance status of 3 or 4 by the ECOG (Eastern Cooperative Oncology Group) scale. All patients were already enrolled for anti-retroviral therapy. The mean time to presentation of cancer after the diagnosis of HIV infection was 5.4 years (Range: 2 months to 15 years). 122 patients had Non-AIDS Defining Cancers (NADC) and 78 had AIDS defining cancers (ADC). Conclusion: In the HAART era, NADCs are more common than ADCs. The most common malignancy in HIV patients is NHL, with DLBCL (Diffuse Large B-Cell Lymphoma) subtype being the commonest in this study. Extranodal presentations are more common than nodal presentation. Standard chemotherapyachieves a response rate of 50% in HIV-NHL cases and 46% in HIV patients with solid cancers. The study illustrates the need for prolonged surveillance for the development of cancer in HIV patients. Early initiation of HAART, optimal chemotherapeutic regimens, radiotherapy protocols, appropriate palliative care and nutritional support should form an integral part of the care of HIV patients with cancer.

Functional Endoscopic Sinus Surgery in Chronic Rhinosinusitis: Impact of Anatomical Variations on Operative Safety and Correlation of CT Imaging with Nasal Endoscopy

Dr. Vivekkumar Makadiya — 2025-04-24

Background: Anatomical variations of the paranasal sinuses influence the pathophysiology of chronic rhinosinusitis (CRS) and may increase operative risk during functional endoscopic sinus surgery (FESS). High resolution computed tomography (CT) is the imaging cornerstone, but its diagnostic yield vis à vis nasal endoscopy in the presence of variants remains debated. Methods: A prospective observational study of 52 adults with medically refractory CRS was undertaken at a tertiary otorhinolaryngology unit. All participants underwent pre operative non contrast CT (Lund–Mackay scoring) and diagnostic nasal endoscopy (Lund–Kennedy scoring), followed by standardised FESS. Anatomical variants, disease extent and peri operative complications were recorded. Diagnostic accuracy indices of CT were calculated against endoscopic findings. Results: Concha bullosa (50 %), deviated nasal septum (46 %) and agger nasi cells (31 %) were the commonest variants. CT correctly identified 88 % of osteomeatal complex obstruction and 83 % of maxillary sinus disease, but sensitivity fell to 69 % for the frontal sinus. Overall CT/endoscopy concordance was substantial (κ = 0.71). Variants significantly associated with persistent sinusitis included concha bullosa (p = 0.02) and agger nasi cells (p = 0.01). Concha bullosa also conferred greater odds of nasolacrimal duct (p = 0.02) and carotid artery (p = 0.05) injury, while septal spurs and polyps correlated with epistaxis (p < 0.03). Post operative complication rates were low (CSF leak 1.9 %; orbital injury 0 %). Conclusion: CT reliably delineates key variants and disease burden, but complementary nasal endoscopy remains essential—particularly for frontal recess and subtle mucosal pathology. Recognition of high risk variants (concha bullosa, agger nasi, accessory ostia) enables tailored surgical strategies that maximise safety without compromising disease clearance.

Correlation of Serum 25 Hydroxy Vitamin D and Iron Deficiency Anaemia in Children Attending a South Indian Tertiary Care Hospital: A Cross Sectional Study

Dr. Vadapalli Sri Vaishnavi — 2025-04-26

Background: The molecule 25 hydroxy vitamin D influences the transcription of hepcidin as well as the transportation of iron through the intestines. New research shows that vitamin D deficiency causes iron deficiency anaemia to worsen although studies about this issue remain limited in the Paediatric population of the Indian sub continent. Methods: In a cross sectional study (July 2022–December 2023) we enrolled 350 term children aged 1 month–12 years with haematological criteria for IDA who were attending Niloufer Hospital, Hyderabad. Children with prematurity, haemolysis, chronic inflammatory disease or current vitamin D/iron therapy were excluded. Clinical details, anthropometry, dietary/sun exposure history, and venous samples for complete blood count, iron profile, C reactive protein, calcium and 25(OH)D were obtained. Pearson’s r evaluated correlations; p < 0.05 was significant. Results: Mean age was 3.29 ± 3.0 years; 63.7 % were boys and 71.1 % rural residents. Moderate IDA predominated (78.3 %); 98.6 % had microcytic hypochromic blood pictures. VDD (< 20 ng mL⁻¹) was ubiquitous (94 %; mean 12.3 ± 5.7 ng mL⁻¹). 25(OH)D correlated positively with haemoglobin (r = 0.33, p = 0.036), ferritin (r = 0.56, p = 0.002) and calcium (r = 0.54, p < 0.001). Children with severe VDD (< 10 ng mL⁻¹) had lower mean Hb (7.7 g dL⁻¹) than those with levels > 20 ng mL⁻¹ (9.3 g dL⁻¹; p = 0.001). Conclusion: Nearly all iron deficient children were concomitantly vitamin D deficient, and serum 25(OH)D showed a moderate, significant positive correlation with haemoglobin and ferritin. Our findings support bidirectional links between vitamin D, iron metabolism and calcium homeostasis and justify routine vitamin D screening in paediatric IDA.

Impact of an Algorithm Based Combination Therapy on Glycemic Control in Newly Diagnosed Type 2 Diabetes Mellitus: A Retrospective Observational Study

Dr.Namrata Vilas Patkar — 2025-04-26

Background:Early, individualized pharmacotherapy is increasingly advocated to achieve prompt glycemic control and preserve β cell function in type 2 diabetes mellitus (T2DM) . Real world evidence on structured, algorithm driven combination regimens at diagnosis remains limited. Methods: We reviewed computerized outpatient records (January–October 2021) of adults with newly diagnosed T2DM attending a specialty clinic. Patients were stratified by baseline glycated hemoglobin (HbA1c) into Group 1 (7–9%), Group 2 (9–11%), and Group 3 (> 11%). A proprietary software generated treatment lines (triple, quadruple, or quintuple oral combinations) according to fasting/post prandial glucose–derived estimated HbA1c. Weight and glycemic indices were recorded at baseline, 3 and 6 months. The primary outcome was change in HbA1c. Results: Of 890 screened patients, 343 met inclusion criteria. Baseline mean ± SD HbA1c was 7.22 ± 0.54%, 9.09 ± 0.61%, and 12.92 ± 2.54% in Groups 1–3, respectively. HbA1c fell significantly at 3 months (–16.9%, –30.1%, –52.2%; p < 0.01) and was sustained at 6 months (Figure 1). Mean fasting and post prandial glucose declined by 14–57% and 27–61%, respectively (Tables 2–3). Body weight remained neutral in Groups 1–2 but increased modestly in Group 3 (+5.4%, p = 0.016). Medication burden decreased over time: in Group 3 the proportion receiving quintuple therapy fell from 100% to 0.5%, while triple or dual therapy rose to 80.6% by month 6 (Figure 2). No severe hypoglycemia or ketoacidosis was reported. Conclusion: An algorithm based strategy delivering intensive, baseline HbA1c matched oral combinations achieved rapid, durable glycemic control with progressive treatment de escalation in newly diagnosed T2DM. Pragmatic digital algorithms may complement current guidelines by operationalizing early combination therapy.

Investigate the Effect of Diabetes Mellitus on Oral Microbial Flora.A Microbiome Metagenomic Study

Dr. Muhammad Umair — 2025-04-28

Introduction: Diabetes mellitus (DM) affects multiple biological systems, including the oral micro biome system because of its significant role in oral and general body health. In the following study, it is aimed to understand how T2DM affects the complexity of human saliva microbiota in search of possible disruption and its consequences: Objective: To examine whether T2DM alters the oral microbial profile and explore the relationship between microbial profile and glycemic control and clinical markers. Methods: This study was a cross-sectional, case-control study with 100 participants where the T2DM case group consists of patients (HbA1c > 6.5%) and 50 healthy control groups. Saliva and oral swab samples were collected in a standardized manner and placed in −80°C until further use. Bacterial nucleic acids were isolated; metagenomics was performed through high-throughput sequencing of 16S rRNA genes. To measure the microbial richness and community differences, alpha and beta diversity statistics were used. In differential abundance analysis, the taxa that are significantly correlated with diabetes were determined. Results: The alpha diversity had lower microbial diversity and relatively higher inequality in T2DM patients compared to the control samples. Beta diversity demonstrated that microbial community structure changed significantly; diabetics were found to be more susceptible to pathogenic genera of Porphyromonas and Fusobacterium. These microbial patterns significantly related to higher HbA1c values and changes in routines of oral care. Conclusion: According to the study, highly relevant dysbiosis has been observed in the setting of T2DM and reduced complexity of oral microbiota with the higher abundance of pathogenic species. The results presented here highlight the importance of diabetes in regulating the structure and composition of oral microbiota and could inform the development of interventions aimed at enhancing oral and overall health in diabetic patients.

Oral Health Behaviour and Knowledge of Adult Diabetic Patients

Maria Rabbani — 2025-04-28

OBJECTIVE The purpose of this meta-analysis and systematic review is to identify and quantify the degree of cariogenic oral health practices and knowledge in the adult diabetic population. Because people with diabetes are at a higher risk for oral diseases and other complications, the perception and behavior of diabetes patients toward their oral hygiene really deserve attention in order to better improve the health outcome of diabetic patients with oral diseases. METHODS An exhaustive meta-analysis and systematic review was led to across different databases, including PubMed, Cochrane Library, and Google Scholar, from initiation to September 2024. Keywords utilized in the pursuit included "oral health behaviour ," "oral Health knowledge," "diabetic patients," and "diabetes and oral Health." Studies included were those that evaluated the oral health behaviour and knowledge of adult diabetic patients. Data extraction and quality appraisal were performed freely by two analysts. RESULTS The systematic review and meta-analysis included 25 studies incorporating a total of 8,400 participants. The discoveries show that while a huge piece of diabetic patients know about the significance of oral health, there is a hole in reasonable application. Normal oral health ways of behaving, like customary brushing and dental visits, were sub-standard. Numerous members needed complete information on the bidirectional connection among diabetes and oral health, including how oral infections can influence glycemic control as well as the other way around. CONCLUSION The systematic review and meta-analysis for developing training and mediation programs focusing on oral Health in diabetic patients. Upgraded patient education can overcome any barrier among knowledge and practice, eventually further developing both oral and generally speaking well-being results for people with diabetes. Healthcare services suppliers ought to integrate oral health education into routine diabetes the executives to address this basic part of patient care.

"Diagnostic Role of Bone Marrow Examination in Pediatric Hematologic Disorders"

Ashutosh Kumar Verma — 2025-04-30

Bone marrow examination (BME) remains one of the most critical diagnostic tools in pediatric hematology, providing valuable insights into a wide range of hematological disorders. This paper reviews the role of bone marrow aspiration and biopsy in diagnosing and prognosticating pediatric hematologic conditions, including leukemia, anemia, idiopathic thrombocytopenic purpura (ITP), and various infections. The review synthesizes findings from multiple studies, with a focus on the diagnostic utility of BMB in pediatric populations, its complementarity with bone marrow aspiration (BMA), and its role in assessing disease progression and treatment response. The paper also explores the challenges of bone marrow examination in resource-limited settings and the necessity of prospective studies to refine clinical guidelines.

Effectiveness of Patients Education in Improving Compliance with Oral Hygiene Practices

Dr Najam Ul Hassan — 2025-04-30

Objective: This Systematic Review and meta-analysis assesses the effectiveness of patient education in improving compliance with oral hygiene practices. Material and Methods: A systematic hunt and meta-analysis was directed across numerous data sets, including PubMed, Cochrane Library, and Google Researcher, for review distributed somewhere in the range of 2010 and 2023. The pursuit terms included "patient education," "oral hygiene," "compliance," "dental health education," and "social mediation." Consideration measures were concentrates on that surveyed the effect of educational mediations on oral hygiene compliance, distributed in peer-explored diaries, and remembered quantitative information for consistence results. Concentrates on not zeroing in on oral hygiene practices, not in English, or lacking unique information were excluded. Results: Out of 2,500 recognized articles, 45 examinations met the consideration models. These investigations incorporated different educational intercessions, remembering one-for one guiding, bunch education meetings, computerized and mixed media assets, and pieces of literature. Quality evaluation of the included examinations was performed utilizing the Cochrane Cooperation's device for surveying the gamble of predisposition. Most examinations displayed a low to direct gamble of inclination, demonstrating solid discoveries. In any case, the heterogeneity in concentrate on plan, test size, and mediation type presented difficulties in normalizing results and playing out a meta-analysis. In end, the proof proposes that patient education is effective in improving compliance with oral hygiene practices, prompting better oral health results. Conclusion: Future exploration ought to zero in on creating normalized educational conventions and evaluating their drawn-out viability across different populaces.