The Role of Vascular–Bone Coupling Disruption in the  Pathophysiology and Progression of Osteoradionecrosis of  the Jaw

Baizad Khan, Nauman Shirazi, Shameen Fatima Shoaib, Usman Manzoor Warraich, Shah Faisal, Suleman Khan

The Role of Vascular–Bone Coupling Disruption in the Pathophysiology and Progression of Osteoradionecrosis of the Jaw

Authors

Baizad Khan, Nauman Shirazi, Shameen Fatima Shoaib, Usman Manzoor Warraich, Shah Faisal, Suleman Khan

Keywords:

Osteoradionecrosis, jaw, pathophysiology, vascular, progression

Abstract

Osteoradionecrosis (ORN) of the jaw is a debilitating radiotherapy complication that is identifiedby impaired bone healing, a lack of vascularity, and a lack of cells. This study was conducted totest the contribution of vascular-bone coupling disruption to the pathophysiology and progression of ORN.

References

Annane D, Depondt J, Aubert P, Villart M, Gehanno P, Gajdos P, et al. Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled trial. J Clin Oncol. 2004;22(24):4893–4900.

Chrcanovic BR, Reher P, Sousa AA, Harris M. Osteoradionecrosis of the jaws a current overview. Part 1: Physiopathology and risk factors. Oral Maxillofac Surg. 2010;14(1):3–16

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Published

2026-04-03

How to Cite

Baizad Khan, Nauman Shirazi, Shameen Fatima Shoaib, Usman Manzoor Warraich, Shah Faisal, Suleman Khan. (2026). The Role of Vascular–Bone Coupling Disruption in the Pathophysiology and Progression of Osteoradionecrosis of the Jaw. International Journal of Pharmacy Research & Technology (IJPRT), 16(1), 1409–1415. Retrieved from https://www.ijprt.org/index.php/pub/article/view/1701