Oral Biological and Immunohistochemical Correlates of  p53 and Ki-67 with Histological Grading and Clinical  Outcomes in Oral Squamous Cell Carcinoma: A Pakistani  Cohort Study

Sarosh Iqbal, Varda Jalil, Maryam Nazir Kiani, Nida Rasheed, Muhammad Waqas Rashid, Roshan Zafar

Oral Biological and Immunohistochemical Correlates of p53 and Ki-67 with Histological Grading and Clinical Outcomes in Oral Squamous Cell Carcinoma: A Pakistani Cohort Study

Authors

Sarosh Iqbal, Varda Jalil, Maryam Nazir Kiani, Nida Rasheed, Muhammad Waqas Rashid, Roshan Zafar

Keywords:

Oral squamous cell carcinoma, p53, Ki-67, immunohistochemistry, histological grade, prognosis, tumor proliferation.

Abstract

Background: Oral squamous cell carcinoma (OSCC) is a biologically aggressive malignancy where molecularbiomarkers such as p53 and Ki-67 may help in assessing tumor behavior and prognosis.
Objective: To assess p53 and Ki-67 expression in OSCC patients and its correlation with histological grade and clinical outcomes.

References

Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J, Huang C. Oral squamous cell carcinomas: state of the field and emerging directions. International journal of oral science. 2023 Sep 22;15(1):44. https://doi.org/10.1038/s41368-023-00249-w

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Published

2026-04-10

How to Cite

Sarosh Iqbal, Varda Jalil, Maryam Nazir Kiani, Nida Rasheed, Muhammad Waqas Rashid, Roshan Zafar. (2026). Oral Biological and Immunohistochemical Correlates of p53 and Ki-67 with Histological Grading and Clinical Outcomes in Oral Squamous Cell Carcinoma: A Pakistani Cohort Study. International Journal of Pharmacy Research & Technology (IJPRT), 16(1), 1648–1655. Retrieved from https://www.ijprt.org/index.php/pub/article/view/1753