Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals

DEVVRET; PRAVEEN KUMAR; KUMUD PANT; ASHISH THAPLIYAL; NEEMA TUFCHI

doi:10.31838/ijprt/07.02.02

2022, Vol: 12, Issue: 2

12 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

IJPRT. 2017; 7(2): 08-14

doi: 10.31838/ijprt/07.02.02

Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI.

Abstract
Rice is a staple crop that is consumed by half of the worlds population. Paddy rice is highly prone to heavy metal toxicity. Low level of heavy metals in rice plant is beneficial for plant growth but its excess can affect the growth of the plant. Consumption of rice contaminated with heavy metal has a potential health risk to human population. Metallothionein (MT) is a metal binding proteins that comes under a class of conserved evolutionary protein molecules. It plays an essential function in the detoxification of heavy metals and homeostasis. Metals with relatively high densities, atomic weights, or atomic numbers are known as heavy metals. Cadmium (Cd), arsenic (As), chromium (Cr), lead (Pb) and zinc (Zn) are highly reactive and toxic to living cells. Plants have described two basic mechanisms such as chelation and sequestration of heavy metals by ligands to counter this problem. The two best-characterized heavy metal-binding ligands in plant cells are the phytochelatins and metallothionein. In the current study, we have generated the three dimensional structure of rice MT protein, identification of active sites of metallothionein and docking study was performed. Homology model of the metallothionein was designed through Phyre2 server. Heavy metals were docked with the metallothionein. The docking analysis and active sites were predicted through iGemDock software. The stable homology structure of the metallothionein was modelled and binding pockets were analyzed. This analysis of binding pocket will help in the in vitro study of metallothionein protein and understanding its role in metal detoxification.

Key words: Metallothionein, Homology modelling, Docking, Binding Pocket.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by DEVVRET Articles by PRAVEEN KUMAR Articles by KUMUD PANT Articles by ASHISH THAPLIYAL Articles by NEEMA TUFCHI
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI. Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals. IJPRT. 2017; 7(2): 08-14. doi:10.31838/ijprt/07.02.02

Web Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI. Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals. https://www.ijprt.org/?mno=302643733 [Access: June 25, 2022]. doi:10.31838/ijprt/07.02.02

AMA (American Medical Association) Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI. Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals. IJPRT. 2017; 7(2): 08-14. doi:10.31838/ijprt/07.02.02

Vancouver/ICMJE Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI. Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals. IJPRT. (2017), [cited June 25, 2022]; 7(2): 08-14. doi:10.31838/ijprt/07.02.02

Harvard Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI (2017) Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals. IJPRT, 7 (2), 08-14. doi:10.31838/ijprt/07.02.02

Turabian Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI. 2017. Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals. International Journal of Pharmacy Research & Technology, 7 (2), 08-14. doi:10.31838/ijprt/07.02.02

Chicago Style

DEVVRET, PRAVEEN KUMAR, KUMUD PANT, ASHISH THAPLIYAL, NEEMA TUFCHI. "Bioinformatics approach toward the Identification of Binding Pockets of Rice Metallothionein and its interaction with the heavy metals." International Journal of Pharmacy Research & Technology 7 (2017), 08-14. doi:10.31838/ijprt/07.02.02

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Most Viewed Articles

Stability Indicating HPLC Method for Simultaneous Estimation of Nicotinamide and Salicylic Acid
FALGUNI TANDEL, PRATIMA MORE
IJPRT. 2018; 8(2): 43-47
» Abstract » doi: 10.31838/ijprt/08.02.05

FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE
ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.
IJPRT. 2018; 8(2): 14-26
» Abstract » doi: 10.31838/ijprt/08.02.02

Antimicrobial activities, antioxidant and phytochemical analysis of methanol and aqueous leaf extract of Phyllathus muellerianus (KUNTZ) Exell
FRED COOLBORN AKHARAIYI* ,ABAYOMI OLABANJO DINA
IJPRT. 2018; 8(1): 29-38
» Abstract » doi: 10.31838/ijprt/08.01.04

Pharmacovigilance system and the future challenges in India-A Perspective
*SANDHYA JAIN*, 1DR VIKAS JAIN, 2RADHA SHARMA
IJPRT. 2018; 8(2): 27-31
» Abstract » doi: 10.31838/ijprt/08.02.03

Piperine : A Bioenhancer
Amar Singh*, Amar Deep
IJPRT. 2011; 1(1): 1-5
» Abstract » doi: 10.31838/ijprt/01.01.01

Most Downloaded

RELEASE KINETICS CONCEPTS AND APPLICATIONS
M. PADMAA PAARAKH , PREETHY ANI JOSE* , CM SETTY , G.V. PETER CHRISTOPER
IJPRT. 2018; 8(1): 12-20
» Abstract » doi: 10.31838/ijprt/08.01.02

A case report on sympneumonic effusion
Sandeep Akkam, Pooja dasari, Nandini Thota,
IJPRT. 2021; 11(2): 17-18
» Abstract » doi: 10.31838/ijprt/11.02.02

FORMULATION AND EVALUATION OF ACTIVATED CHARCOAL PEEL OFF MASK
SWETA V.KULKARNI*, DR.ARUN K.GUPTA, SHUBHAM BHAWSAR
IJPRT. 2019; 9(2): 44-48
» Abstract » doi: 10.31838/ijprt/09.02.06

Medicinal vegetal use by traditional healers in Ekiti State of Nigeria for diabetes treatment
AKHARAIYI, FRED COOLBORN , ADEROBA ADEYEMI ADEGBEMISIPO
IJPRT. 2018; 8(1): 21-28
» Abstract » doi: 10.31838/ijprt/08.01.03

Most Cited Articles

Piperine : A Bioenhancer
Amar Singh*, Amar Deep
IJPRT. 2011; 1(1): 1-5
» Abstract » doi: 10.31838/ijprt/01.01.01
Cited : 5 times [Click to see citing articles]

Biodiversity and conservation Ferns Diversity in different forests of Dehradun district
CHHAYA SINGH, BRIJESH KUMAR, ANJU RANI, KAMLA DHYANI, RAJ SINGH
IJPRT. 2017; 7(2): 01-07
» Abstract » doi: 10.31838/ijprt/07.02.01
Cited : 3 times [Click to see citing articles]

A Preliminary Investigation of Moringa Oleifera Lam Gum As a Pharmaceutical Excipient
Dhiren P Shah*, Vineet C Jain, Hitesh P Dalvadi, Vinod D Ramani, Kajal G Patel, Mahesh G Saralai, Girish K Jani
IJPRT. 2011; 1(1): 12-16
» Abstract » doi: 10.31838/ijprt/01.01.03
Cited : 2 times [Click to see citing articles]

EFFECT OF SEED EXTRACTS OF Elettaria cardamomum ON CALCIUM OXALATE CRYSTALLIZATION
Manish A. Patel, Paras K. Patel, Dr. Avinash K Seth
IJPRT. 2011; 1(1): 21-25
» Abstract » doi: 10.31838/ijprt/01.01.05
Cited : 2 times [Click to see citing articles]

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in International Journal of Pharmacy Research & Technology are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright � 2022 International Journal of Pharmacy Research & Technology All Rights Reserved. Subject to change without notice from or liability to International Journal of Pharmacy Research & Technology. For best results, please use Internet Explorer or Google Chrome	Contact Information International Journal of Pharmacy Research & Technology (IJPRT) C/O Advanced Scientific Research, 21 Thamotharan Street, Salem, Tamilnadu-636009 Phone: +91-6383437191 Email : ijprtjournal@gmail.com

POLICIES & JOURNAL LINKS

Contact Information

How to cite this article