Three-dose intra-articular platelet-rich plasma versus single-dose hylan G-F 20  for symptomatic knee osteoarthritis: a randomized comparative study

Rasheed Ahmed Bhatti, Syed Muhammad Azfar, Nizam Ahmed, Lachman Das Maheshwari, Sajjad Hussain Bhatti, Sijad Ahmed Mahar

Three-dose intra-articular platelet-rich plasma versus single-dose hylan G-F 20 for symptomatic knee osteoarthritis: a randomized comparative study

Authors

Rasheed Ahmed Bhatti, Syed Muhammad Azfar, Nizam Ahmed, Lachman Das Maheshwari, Sajjad Hussain Bhatti, Sijad Ahmed Mahar

Keywords:

knee osteoarthritis; platelet-rich plasma; hylan G-F 20; hyaluronic acid; intra articular injection; WOMAC; visual analogue scale

Abstract

Background :-Knee osteoarthritis (OA) is a common causeof pain and functional limitation. Platelet-rich plasma (PRP) and hyaluronic-acidviscosupplementation are used as intraarticular treatments, but comparative resultsvary across studies and protocols.

References

1. Hunter Osteoarthritis. DJ, Bierma-Zeinstra S. Lancet. 2019;393(10182):1745–1759.

2. Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis 2014;73(7):1323–1330.

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Published

2026-10-19

How to Cite

Rasheed Ahmed Bhatti, Syed Muhammad Azfar, Nizam Ahmed, Lachman Das Maheshwari, Sajjad Hussain Bhatti, Sijad Ahmed Mahar. (2026). Three-dose intra-articular platelet-rich plasma versus single-dose hylan G-F 20 for symptomatic knee osteoarthritis: a randomized comparative study . International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 6682–6690. Retrieved from https://www.ijprt.org/index.php/pub/article/view/3384