Morphological Transition and Fluconazole Resistance of Candida albicans  Experiencing Simulated Microgravity Stress

Sarah Sheraz, Mariam Aziz, Nida Ayesha, Sonia Tahir, Faiz Ahmed Faiz, Fariha Ahmad Khan

Morphological Transition and Fluconazole Resistance of Candida albicans Experiencing Simulated Microgravity Stress

Authors

Sarah Sheraz, Mariam Aziz, Nida Ayesha, Sonia Tahir, Faiz Ahmed Faiz, Fariha Ahmad Khan

Keywords:

Candida albicans; simulated microgravity; fluconazole; antifungal resistance; yeast hyphal transition; filamentation; biofilm; HWP1; ERG11; efflux pumps

Abstract

Background :-Candida albicans is a major opportunisticfungal pathogen capable of reversibletransitions between yeast, pseudohyphal, andtrue hyphal morphologies. These phenotypic transitions are closely associated withadhesion, biofilm development, virulence

References

1. Brown AJP, Brown GD, Netea MG, Gow NAR. Metabolism impacts upon Candida albicans hypha formation and host interactions. Curr Opin

Microbiol. 2014;20:83–89.

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Published

2026-10-08

How to Cite

Sarah Sheraz, Mariam Aziz, Nida Ayesha, Sonia Tahir, Faiz Ahmed Faiz, Fariha Ahmad Khan. (2026). Morphological Transition and Fluconazole Resistance of Candida albicans Experiencing Simulated Microgravity Stress . International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 6060–6073. Retrieved from https://www.ijprt.org/index.php/pub/article/view/3295