Insulin Clearance, Hepatic Glucose Regulation, and Glycemic Control in  Patients With Type 2 Diabetes Mellitus: An Observational Clinical Study

Muhammad Atif Ata, Nadeem Abbas, Arisha Amjad, Irfan Ahmad, Amana Idnan, Jahanzaib

Insulin Clearance, Hepatic Glucose Regulation, and Glycemic Control in Patients With Type 2 Diabetes Mellitus: An Observational Clinical Study

Authors

Muhammad Atif Ata, Nadeem Abbas, Arisha Amjad, Irfan Ahmad, Amana Idnan, Jahanzaib

Keywords:

Type 2 diabetes mellitus; insulin clearance; hepatic glucose production; C peptide; insulin resistance; fasting plasma glucose; HbA1c; glycemic control.

Abstract

Background:Type 2 diabetes mellitus (T2DM) ischaracterized by insulin resistance,progressive pancreatic β-cell dysfunction,
and impaired regulation of hepatic glucose production. Insulin clearance influencescirculating insulin concentrations and maycontribute to differences in glycemic control

References

1. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced

overview. Diabetes Care. 1992;15(3):318368. doi:10.2337/diacare.15.3.318

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Published

2026-10-24

How to Cite

Muhammad Atif Ata, Nadeem Abbas, Arisha Amjad, Irfan Ahmad, Amana Idnan, Jahanzaib. (2026). Insulin Clearance, Hepatic Glucose Regulation, and Glycemic Control in Patients With Type 2 Diabetes Mellitus: An Observational Clinical Study . International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 6997–7009. Retrieved from https://www.ijprt.org/index.php/pub/article/view/3436