Comparison of Pharmacological and Non-Pharmacological Interventions  for Orthodontic Pain Management: A Systematic Review of Randomized  Controlled Trials and Primary Studies

Ivana Isna Fenty Fadina,  Budi Suhartono

Comparison of Pharmacological and Non-Pharmacological Interventions for Orthodontic Pain Management: A Systematic Review of Randomized Controlled Trials and Primary Studies

Authors

Ivana Isna Fenty Fadina, Budi Suhartono

Keywords:

Orthodontic pain; nonsteroidal anti-inflammatory drugs; low-level laser therapy; cognitive behavioral therapy; vibration therapy; acupuncture; tooth movement; VAS; patient compliance

Abstract

Background: Orthodontic pain, affecting 70–95% of patients within 24–72 hours followingarchwire placement, represents the most prevalent adverse effect of fixed appliance therapyand significantly impacts treatment adherence and quality of life. Despite its ubiquity, clinical practice remains heterogeneous without robust comparative evidence to guide decisionmaking.

References

1. Wang J, Jian F, Chen J, Ye NS, Huang YH, Wang S, et al. Cognitive Behavioral Therapy for Orthodontic Pain Control: A Randomized Trial. 2012;91(6):580–585. J 10.1177/0022034512444446. from: Dent Res. DOI: Available https://consensus.app/papers/details/39107f2ab39d562fbb5132f7061fa00b/

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Published

2026-09-12

How to Cite

Ivana Isna Fenty Fadina, Budi Suhartono. (2026). Comparison of Pharmacological and Non-Pharmacological Interventions for Orthodontic Pain Management: A Systematic Review of Randomized Controlled Trials and Primary Studies . International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 4670–4709. Retrieved from https://www.ijprt.org/index.php/pub/article/view/3082