E-ISSN 2250-0944 | ISSN 2250-1150
 

Review Article 


A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS

Savithri Somala, Bhavani Yelicherla, Salma Shaik.

Abstract
Remdesivir is the first drug that has been approved by the US Food and Drug Administration (FDA) for clinical use in hospitalized patients with COVID-19 illness. Remdesivir is a broad-spectrum antiviral agent that has previously demonstrated antiviral activity against filoviruses (Ebola viruses,Marburg virus), coronaviruses (SARS-CoV, MERS-Co-V, SARS-CoV-2), paramyxoviruses and Pnemoviridae . Remdesivir was initially developed against the Ebola virus based on its antiviral properties demonstrated in vitro and in vivo in animal models but failed to demonstrate efficacy in randomized clinical trials. Remdesivir was shown to exhibit antiviral activity against SARS-CoV-2 in vitro studies, and it was proposed as an investigational drug early during the pandemic. However,based on data from randomized clinical trials that demonstrated superior clinical efficacy of remdesivir to placebo, remdesivir is the first and only available therapeutic drug that has been approved by the US Food and Drug Administration (FDA) for clinical use in the management of patients with severe suspected or laboratory-confirmed COVID-19. COVID -19 is a disease caused by SARS-CoV-2 that can trigger what doctors call a respiratory tract infection. It can affect your
upper respiratory tract (sinuses, nose, and throat) or lower respiratory tract (windpipe
and lungs).It spreads the same way other coronaviruses do, mainly through person-to-person
contact. Infections range from mild to deadly.

Key words: Remedesivir, SARS-CoV-2, Food and drug administration (FDA), MERS-CoV-2, Clinical trials.


 
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How to Cite this Article
Pubmed Style

SS, BY, Shaik S. A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. IJPRT. 2022; 12(2): 32-38. doi:10.31838/ijprt/12.02.05


Web Style

SS, BY, Shaik S. A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. https://www.ijprt.org/?mno=135819 [Access: June 25, 2022]. doi:10.31838/ijprt/12.02.05


AMA (American Medical Association) Style

SS, BY, Shaik S. A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. IJPRT. 2022; 12(2): 32-38. doi:10.31838/ijprt/12.02.05



Vancouver/ICMJE Style

SS, BY, Shaik S. A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. IJPRT. (2022), [cited June 25, 2022]; 12(2): 32-38. doi:10.31838/ijprt/12.02.05



Harvard Style

, S. S., , . B. Y. & Shaik, . S. (2022) A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. IJPRT, 12 (2), 32-38. doi:10.31838/ijprt/12.02.05



Turabian Style

, Savithri Somala, Bhavani Yelicherla, and Salma Shaik. 2022. A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. International Journal of Pharmacy Research & Technology, 12 (2), 32-38. doi:10.31838/ijprt/12.02.05



Chicago Style

, Savithri Somala, Bhavani Yelicherla, and Salma Shaik. "A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS." International Journal of Pharmacy Research & Technology 12 (2022), 32-38. doi:10.31838/ijprt/12.02.05



MLA (The Modern Language Association) Style

, Savithri Somala, Bhavani Yelicherla, and Salma Shaik. "A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS." International Journal of Pharmacy Research & Technology 12.2 (2022), 32-38. Print. doi:10.31838/ijprt/12.02.05



APA (American Psychological Association) Style

, S. S., , . B. Y. & Shaik, . S. (2022) A REVIEW ON UTILISATION OF REMDESIVIR IN TREATING COVID – 19 : THERAPEUTIC REPURPOSING AND UNMET CLINICAL NEEDS. International Journal of Pharmacy Research & Technology, 12 (2), 32-38. doi:10.31838/ijprt/12.02.05





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