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Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel.

Abstract
Leuprolide acetate is used in treatment of choice for advanced prostate cancer and Due to shortcomings associated with subcutaneous injection of Leuprolide acetate an attempt was made to develop nanoparticle based depot injection for the same. Processing parameters i.e. concentration of surfactant, volume of internal aqueous phase of primary emulsion and volume of external aqueous phase of secondary emulsion, sonication amplitude and sonication time and polyethylene glycol -200 concentrations in internal aqueous phase were optimized. 4% w/v span-83, 0.35 % w/v polyvinyl alcohol to external aqueous phase, 250 µl as the volume of internal aqueous phase of primary emulsion and 40 ml as volume of external aqueous phase of secondary emulsion, 80W amplitude as sonication amplitude and 45 second as sonication time and 40 % w/v polyethylene glycol -200 were found as optimum parameters and selected for further studies

Key words: Prostate cancer, Leuprolide acetate, Nanoparticle, Depot Injection, Processing Parameters


 
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How to Cite this Article
Pubmed Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. IJPRT. 2012; 2(2): 24-27. doi:10.31838/ijprt/02.02.06


Web Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. https://www.ijprt.org/?mno=302643717 [Access: June 25, 2022]. doi:10.31838/ijprt/02.02.06


AMA (American Medical Association) Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. IJPRT. 2012; 2(2): 24-27. doi:10.31838/ijprt/02.02.06



Vancouver/ICMJE Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. IJPRT. (2012), [cited June 25, 2022]; 2(2): 24-27. doi:10.31838/ijprt/02.02.06



Harvard Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel (2012) Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. IJPRT, 2 (2), 24-27. doi:10.31838/ijprt/02.02.06



Turabian Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. 2012. Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. International Journal of Pharmacy Research & Technology, 2 (2), 24-27. doi:10.31838/ijprt/02.02.06



Chicago Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. "Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone." International Journal of Pharmacy Research & Technology 2 (2012), 24-27. doi:10.31838/ijprt/02.02.06



MLA (The Modern Language Association) Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel. "Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone." International Journal of Pharmacy Research & Technology 2.2 (2012), 24-27. Print. doi:10.31838/ijprt/02.02.06



APA (American Psychological Association) Style

Rushik Ghodasara, D. M. Patel, Umang Ghodasara, Nishit Gohel (2012) Optimization of Formulation Parameters for Development of Depot Injection Containing Hormone. International Journal of Pharmacy Research & Technology, 2 (2), 24-27. doi:10.31838/ijprt/02.02.06





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