Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model

M.Kavitha& 1645;; P.T.Srinivasan; G. Renuga and L.V.Jayakumar

doi:10.31838/ijprt/04.02.01

2023, Vol: 13, Issue: 2

13 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Review Article

IJPRT. 2014; 4(2): 01-04

doi: 10.31838/ijprt/04.02.01

Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model

M.Kavitha& 1645;, P.T.Srinivasan, G. Renuga and L.V.Jayakumar.

Abstract
Mukia maderaspatana L. (called as musumusukkai in Tamil) is an important medicinal plant used as a herbal drug in
cough and cold by folklores. The present study was carried out to evaluate the cytotoxic effect of various leaf extract
(hexane, chloroform, acetone, ethylacetate, ethanol and aqueous) of M. Maderaspatana on meristematic cells of root tips of
Allium cepa. Locally available Allium cepa bulbs were grown in 50ml water for 48 hours for root sprouting and then they
were exposed to 10mg/ml concentration of each of the extract separately for 48 hours. Tap water was used as control and the
cytotoxic drug methotrexate (1mg/ml) served as standard. The results indicated that the mitotic index and root growth rate of
A.cepa were considerably decreased in treated in comparison to the control. Also the most effective extract was found to be
acetone which reduced the mitotic index significantly. Its EC50 was found to be 10 mg/ml. Further, it was able to induce a
high DNA fragmentation followed by leaf ethanol extract in Allium cepa root tip cells.

Key words: Mukia maderaspatana, Allium cepa, methotrexate, mitotic index, EC50, DNA fragmentation

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by M.Kavitha& 1645; Articles by P.T.Srinivasan Articles by G. Renuga and L.V.Jayakumar
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Ma, L.V.Jayakumar ,PGRa. Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. IJPRT. 2014; 4(2): 01-04. doi:10.31838/ijprt/04.02.01

Web Style

Ma, L.V.Jayakumar ,PGRa. Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. https://www.ijprt.org/?mno=302643689 [Access: February 28, 2023]. doi:10.31838/ijprt/04.02.01

AMA (American Medical Association) Style

Ma, L.V.Jayakumar ,PGRa. Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. IJPRT. 2014; 4(2): 01-04. doi:10.31838/ijprt/04.02.01

Vancouver/ICMJE Style

Ma, L.V.Jayakumar ,PGRa. Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. IJPRT. (2014), [cited February 28, 2023]; 4(2): 01-04. doi:10.31838/ijprt/04.02.01

Harvard Style

, M. a. . & L.V.Jayakumar, ,. P. G. R. a. (2014) Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. IJPRT, 4 (2), 01-04. doi:10.31838/ijprt/04.02.01

Turabian Style

, M.Kavitha and , and , P.T.Srinivasan, G. Renuga and L.V.Jayakumar. 2014. Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. International Journal of Pharmacy Research & Technology, 4 (2), 01-04. doi:10.31838/ijprt/04.02.01

Chicago Style

, M.Kavitha and , and , P.T.Srinivasan, G. Renuga and L.V.Jayakumar. "Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model." International Journal of Pharmacy Research & Technology 4 (2014), 01-04. doi:10.31838/ijprt/04.02.01

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

, M. a. . & L.V.Jayakumar, ,. P. G. R. a. (2014) Evaluation of Antimitotic Activity of Mukia maderaspatana L. Leaf Extract in Allium cepa Root Model. International Journal of Pharmacy Research & Technology, 4 (2), 01-04. doi:10.31838/ijprt/04.02.01

Most Viewed Articles

Stability Indicating HPLC Method for Simultaneous Estimation of Nicotinamide and Salicylic Acid
FALGUNI TANDEL, PRATIMA MORE
IJPRT. 2018; 8(2): 43-47
» Abstract » doi: 10.31838/ijprt/08.02.05

FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE
ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.
IJPRT. 2018; 8(2): 14-26
» Abstract » doi: 10.31838/ijprt/08.02.02

Antimicrobial activities, antioxidant and phytochemical analysis of methanol and aqueous leaf extract of Phyllathus muellerianus (KUNTZ) Exell
FRED COOLBORN AKHARAIYI* ,ABAYOMI OLABANJO DINA
IJPRT. 2018; 8(1): 29-38
» Abstract » doi: 10.31838/ijprt/08.01.04

Pharmacovigilance system and the future challenges in India-A Perspective
*SANDHYA JAIN*, 1DR VIKAS JAIN, 2RADHA SHARMA
IJPRT. 2018; 8(2): 27-31
» Abstract » doi: 10.31838/ijprt/08.02.03

Piperine : A Bioenhancer
Amar Singh*, Amar Deep
IJPRT. 2011; 1(1): 1-5
» Abstract » doi: 10.31838/ijprt/01.01.01

Most Downloaded

A case report on sympneumonic effusion
Sandeep Akkam, Pooja dasari, Nandini Thota,
IJPRT. 2021; 11(2): 17-18
» Abstract » doi: 10.31838/ijprt/11.02.02

RELEASE KINETICS CONCEPTS AND APPLICATIONS
M. PADMAA PAARAKH , PREETHY ANI JOSE* , CM SETTY , G.V. PETER CHRISTOPER
IJPRT. 2018; 8(1): 12-20
» Abstract » doi: 10.31838/ijprt/08.01.02

FORMULATION AND EVALUATION OF ACTIVATED CHARCOAL PEEL OFF MASK
SWETA V.KULKARNI*, DR.ARUN K.GUPTA, SHUBHAM BHAWSAR
IJPRT. 2019; 9(2): 44-48
» Abstract » doi: 10.31838/ijprt/09.02.06

Medicinal vegetal use by traditional healers in Ekiti State of Nigeria for diabetes treatment
AKHARAIYI, FRED COOLBORN , ADEROBA ADEYEMI ADEGBEMISIPO
IJPRT. 2018; 8(1): 21-28
» Abstract » doi: 10.31838/ijprt/08.01.03

Most Cited Articles

Piperine : A Bioenhancer
Amar Singh*, Amar Deep
IJPRT. 2011; 1(1): 1-5
» Abstract » doi: 10.31838/ijprt/01.01.01
Cited : 5 times [Click to see citing articles]

Biodiversity and conservation Ferns Diversity in different forests of Dehradun district
CHHAYA SINGH, BRIJESH KUMAR, ANJU RANI, KAMLA DHYANI, RAJ SINGH
IJPRT. 2017; 7(2): 01-07
» Abstract » doi: 10.31838/ijprt/07.02.01
Cited : 3 times [Click to see citing articles]

A Preliminary Investigation of Moringa Oleifera Lam Gum As a Pharmaceutical Excipient
Dhiren P Shah*, Vineet C Jain, Hitesh P Dalvadi, Vinod D Ramani, Kajal G Patel, Mahesh G Saralai, Girish K Jani
IJPRT. 2011; 1(1): 12-16
» Abstract » doi: 10.31838/ijprt/01.01.03
Cited : 2 times [Click to see citing articles]

EFFECT OF SEED EXTRACTS OF Elettaria cardamomum ON CALCIUM OXALATE CRYSTALLIZATION
Manish A. Patel, Paras K. Patel, Dr. Avinash K Seth
IJPRT. 2011; 1(1): 21-25
» Abstract » doi: 10.31838/ijprt/01.01.05
Cited : 2 times [Click to see citing articles]

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in International Journal of Pharmacy Research & Technology are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright � 2023 International Journal of Pharmacy Research & Technology All Rights Reserved. Subject to change without notice from or liability to International Journal of Pharmacy Research & Technology. For best results, please use Internet Explorer or Google Chrome	Contact Information International Journal of Pharmacy Research & Technology (IJPRT) C/O Advanced Scientific Research, 21 Thamotharan Street, Salem, Tamilnadu-636009 Phone: +91-6383437191 Email : ijprtjournal@gmail.com

POLICIES & JOURNAL LINKS

Contact Information

How to cite this article