Comparison of Mifepristone-Misoprostol versus Dinoprostone-Misoprostol  for Second-Trimester Pregnancy Termination: A Randomized Controlled  Trial

Dr Mandeep Bayan

Comparison of Mifepristone-Misoprostol versus Dinoprostone-Misoprostol for Second-Trimester Pregnancy Termination: A Randomized Controlled Trial

Authors

Dr Mandeep Bayan

Keywords:

Abortion, Induced /mifepristone / Dinoprostone/ misoprostol / sublingual / Pregnancy Trimester, Second

Abstract

Background: Second-trimester abortions account for 10–15% of induced abortions globally.Misoprostol is widely used due to its efficacy and accessibility, with sublingualadministration often preferred for convenience. Cervical priming with oral mifepristone(inducing collagen breakdown) or endocervical Dinoprostone/PGE2 gel (promoting cervicalremodelling) may improve outcomes, but comparative data are limited.

References

Harris LH, Grossman D. Confronting the challenge of unsafe second‐trimester abortion. Int J Gynecol Obstet. 2011 Oct;115(1):77–9

Wildschut H, Both MI, Medema S, Thomee E, Wildhagen MF, Kapp N. Medical methods for mid-trimester termination of pregnancy. Cochrane Fertility Regulation Group, editor. Cochrane Database Syst Rev [Internet]. 2011 Jan 19 [cited 2024 Mar 8];2011(2). Available from: http://doi.wiley.com/10.1002/14651858.CD005216.pub2

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Published

2025-07-12

How to Cite

Dr Mandeep Bayan. (2025). Comparison of Mifepristone-Misoprostol versus Dinoprostone-Misoprostol for Second-Trimester Pregnancy Termination: A Randomized Controlled Trial . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 253–268. Retrieved from https://www.ijprt.org/index.php/pub/article/view/682