Efficacy of Bile Acid Sequestrants in Treating Bile Acid Diarrhea: A Double Blind, Placebo-Controlled RCT

Muhammad Rehman Afzal, Syed Osama Talat, Jahanzaib, Mian Sajjad Ahmad, Shahzad Latif, Attiya Arif

Efficacy of Bile Acid Sequestrants in Treating Bile Acid Diarrhea: A Double Blind, Placebo-Controlled RCT

Authors

Muhammad Rehman Afzal, Syed Osama Talat, Jahanzaib, Mian Sajjad Ahmad, Shahzad Latif, Attiya Arif

Keywords:

Abstract

A double-blind, placebo-controlled randomized clinical trial evaluated the efficacy of colesevelam1.875 g twice daily in adults with bile-acid diarrhea (BAD) confirmed by SeHCAT retention≤10 %. Eighty participants were randomized

References

Bajor A, Gillberg PG, Abrahamsson H. Bile acids: short and long-term effects in the intestine.

Scand J Gastroenterol. https://doi.org/10.1080/00365521.2022.2145716 2023;58(3):217-225.

Camilleri M. Bile acid diarrhea: prevalence, pathogenesis, and therapy. Clin Gastroenterol

Hepatol. 2022;20(4):873–880.e2. DOI: https://doi.org/10.1016/j.cgh.2021.10.016

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Published

2025-06-30

How to Cite

Muhammad Rehman Afzal, Syed Osama Talat, Jahanzaib, Mian Sajjad Ahmad, Shahzad Latif, Attiya Arif. (2025). Efficacy of Bile Acid Sequestrants in Treating Bile Acid Diarrhea: A Double Blind, Placebo-Controlled RCT . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 170–180. Retrieved from https://www.ijprt.org/index.php/pub/article/view/670