Hepatoprotective of Eclipta Alba Methanolic Extract in Isoniazid and Rifampicin Proved Oxidative Hepatic Injury
Keywords:Eclipta alba, isoniazid, rifampicin, hepatotoxicity, oxidative stress, antioxidants
The current study was undertaken to evaluate the preclinical efficacy of methanolic extract of Eclipta alba (MEEA) against isoniazid and rifampicin (INH-RIF) induced hepatic injury. Animals were randomly divided in five groups, vehicle (control) or INH-RIF (50 mg/kg, i.p.) or MEEA (200 and 400mg/kg, p.o.) or standard silymarin for 28 days. INH-RIF intoxicated rats displayed significant (p<0.05) elevation in serum hepatic markers, lipid peroxidation and decrease in antioxidants like SOD, CAT, Gpx and GSH in liver tissue. Treatment with MEEA (200 and 400mg/kg, p.o.) restored the altered biochemical level to normalcy. Thus, outcome of the study reveals that MEEA showed promising hepatoprotective activity in INH-RIF induced cardiac damage mediated by its membrane stabilizing and antioxidant effect.
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