Hepatoprotective of Eclipta Alba Methanolic Extract in Isoniazid and Rifampicin Proved Oxidative Hepatic Injury

Aithamraju Satish Chandra; P. Shanmugapandiyan

doi:10.31838/ijprt/10.02.09

Hepatoprotective of Eclipta Alba Methanolic Extract in Isoniazid and Rifampicin Proved Oxidative Hepatic Injury

Authors

Aithamraju Satish Chandra Research Scholar, Prist University, Tamilnadu, India
P. Shanmugapandiyan Professor and Dean, School of Pharmacy, Sathyabama Institute of Science and Technology (Deemed to be university), Chennai.

DOI:

https://doi.org/10.31838/ijprt/10.02.09

Keywords:

Eclipta alba, isoniazid, rifampicin, hepatotoxicity, oxidative stress, antioxidants

Abstract

The current study was undertaken to evaluate the preclinical efficacy of methanolic extract of Eclipta alba (MEEA) against isoniazid and rifampicin (INH-RIF) induced hepatic injury. Animals were randomly divided in five groups, vehicle (control) or INH-RIF (50 mg/kg, i.p.) or MEEA (200 and 400mg/kg, p.o.) or standard silymarin for 28 days. INH-RIF intoxicated rats displayed significant (p<0.05) elevation in serum hepatic markers, lipid peroxidation and decrease in antioxidants like SOD, CAT, Gpx and GSH in liver tissue. Treatment with MEEA (200 and 400mg/kg, p.o.) restored the altered biochemical level to normalcy. Thus, outcome of the study reveals that MEEA showed promising hepatoprotective activity in INH-RIF induced cardiac damage mediated by its membrane stabilizing and antioxidant effect.

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Published

2023-03-21

How to Cite

Chandra, A. S., & Shanmugapandiyan, P. (2023). Hepatoprotective of Eclipta Alba Methanolic Extract in Isoniazid and Rifampicin Proved Oxidative Hepatic Injury. International Journal of Pharmacy Research & Technology (IJPRT), 10(2), 74–79. https://doi.org/10.31838/ijprt/10.02.09