E-ISSN 2250-0944 | ISSN 2250-1150
 

- 


Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee.

Abstract
Poor aqueous solubility and low oral bioavailability of Carvedilol, a novel third generation anti-hypertensive drug
necessitates exploration of formulation strategies to achieve quick onset of action and prolonged drug release from a dosage
form. In the present study, disintegration-accelerated solid dispersion-based matrix tablet of Carvedilol has been designed
with L-HPC LH-11, mannitol and Avicel PH-102. Addition of higher percentage of L-HPC (3.5% w/w) in the tablet
formulation, TSD-Ľ resulted in maximum rate of simulated saliva uptake of 0.568 ± 0.02 mg/sec and minimum
disintegration time of 7mins 10.29 ± 14.45 secs in phosphate buffer (pH-6.8). Fibrous nature of L-HPC leads to enhanced
saliva uptake by wicking action into the porous network of tablet resulting in high swell volume without gelling. Creation of
hydrophilic network promoted the disintegrant activity. However, no improvement in dissolution efficiency and mean
dissolution time for TSD-Ľ could be observed in comparison to the batch, TSD-L. Fitting of drug release data to the kinetic
models showed that the formulation batches obeyed Higuchi kinetics i.e. diffusion of drug occurred from hydrophilic
swellable matrix.

Key words: Hydrophilic swellable matrix, Carvedilol, L-HPC


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ushasi Das
Articles by Gopa Roy Biswas And Sutapa Biswas Majee
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. IJPRT. 2013; 3(2): 22-28. doi:10.31838/ijprt/03.02.05


Web Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. https://www.ijprt.org/?mno=302643707 [Access: February 28, 2023]. doi:10.31838/ijprt/03.02.05


AMA (American Medical Association) Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. IJPRT. 2013; 3(2): 22-28. doi:10.31838/ijprt/03.02.05



Vancouver/ICMJE Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. IJPRT. (2013), [cited February 28, 2023]; 3(2): 22-28. doi:10.31838/ijprt/03.02.05



Harvard Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee (2013) Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. IJPRT, 3 (2), 22-28. doi:10.31838/ijprt/03.02.05



Turabian Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. 2013. Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. International Journal of Pharmacy Research & Technology, 3 (2), 22-28. doi:10.31838/ijprt/03.02.05



Chicago Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. "Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol." International Journal of Pharmacy Research & Technology 3 (2013), 22-28. doi:10.31838/ijprt/03.02.05



MLA (The Modern Language Association) Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee. "Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol." International Journal of Pharmacy Research & Technology 3.2 (2013), 22-28. Print. doi:10.31838/ijprt/03.02.05



APA (American Psychological Association) Style

Ushasi Das, Gopa Roy Biswas And Sutapa Biswas Majee (2013) Fabrication of a Disintegration-Accelerated Matrix Tablet of Carvedilol. International Journal of Pharmacy Research & Technology, 3 (2), 22-28. doi:10.31838/ijprt/03.02.05





Most Viewed Articles
  • Stability Indicating HPLC Method for Simultaneous Estimation of Nicotinamide and Salicylic Acid
    FALGUNI TANDEL, PRATIMA MORE
    IJPRT. 2018; 8(2): 43-47
    » Abstract » doi: 10.31838/ijprt/08.02.05

  • FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE
    ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.
    IJPRT. 2018; 8(2): 14-26
    » Abstract » doi: 10.31838/ijprt/08.02.02

  • Antimicrobial activities, antioxidant and phytochemical analysis of methanol and aqueous leaf extract of Phyllathus muellerianus (KUNTZ) Exell
    FRED COOLBORN AKHARAIYI* ,ABAYOMI OLABANJO DINA
    IJPRT. 2018; 8(1): 29-38
    » Abstract » doi: 10.31838/ijprt/08.01.04

  • Pharmacovigilance system and the future challenges in India-A Perspective
    *SANDHYA JAIN*, 1DR VIKAS JAIN, 2RADHA SHARMA
    IJPRT. 2018; 8(2): 27-31
    » Abstract » doi: 10.31838/ijprt/08.02.03

  • Piperine : A Bioenhancer
    Amar Singh*, Amar Deep
    IJPRT. 2011; 1(1): 1-5
    » Abstract » doi: 10.31838/ijprt/01.01.01

  • Most Downloaded
  • A case report on sympneumonic effusion
    Sandeep Akkam, Pooja dasari, Nandini Thota,
    IJPRT. 2021; 11(2): 17-18
    » Abstract » doi: 10.31838/ijprt/11.02.02

  • RELEASE KINETICS – CONCEPTS AND APPLICATIONS
    M. PADMAA PAARAKH , PREETHY ANI JOSE* , CM SETTY , G.V. PETER CHRISTOPER
    IJPRT. 2018; 8(1): 12-20
    » Abstract » doi: 10.31838/ijprt/08.01.02

  • FORMULATION AND EVALUATION OF ACTIVATED CHARCOAL PEEL OFF MASK
    SWETA V.KULKARNI*, DR.ARUN K.GUPTA, SHUBHAM BHAWSAR
    IJPRT. 2019; 9(2): 44-48
    » Abstract » doi: 10.31838/ijprt/09.02.06

  • Medicinal vegetal use by traditional healers in Ekiti State of Nigeria for diabetes treatment
    AKHARAIYI, FRED COOLBORN , ADEROBA ADEYEMI ADEGBEMISIPO
    IJPRT. 2018; 8(1): 21-28
    » Abstract » doi: 10.31838/ijprt/08.01.03

  • FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE
    ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.
    IJPRT. 2018; 8(2): 14-26
    » Abstract » doi: 10.31838/ijprt/08.02.02

  • Most Cited Articles
  • Piperine : A Bioenhancer
    Amar Singh*, Amar Deep
    IJPRT. 2011; 1(1): 1-5
    » Abstract » doi: 10.31838/ijprt/01.01.01
    Cited : 5 times [Click to see citing articles]

  • Biodiversity and conservation Ferns Diversity in different forests of Dehradun district
    CHHAYA SINGH, BRIJESH KUMAR, ANJU RANI, KAMLA DHYANI, RAJ SINGH
    IJPRT. 2017; 7(2): 01-07
    » Abstract » doi: 10.31838/ijprt/07.02.01
    Cited : 3 times [Click to see citing articles]

  • Stability Indicating HPLC Method for Simultaneous Estimation of Nicotinamide and Salicylic Acid
    FALGUNI TANDEL, PRATIMA MORE
    IJPRT. 2018; 8(2): 43-47
    » Abstract » doi: 10.31838/ijprt/08.02.05
    Cited : 3 times [Click to see citing articles]

  • A Preliminary Investigation of Moringa Oleifera Lam Gum As a Pharmaceutical Excipient
    Dhiren P Shah*, Vineet C Jain, Hitesh P Dalvadi, Vinod D Ramani, Kajal G Patel, Mahesh G Saralai, Girish K Jani
    IJPRT. 2011; 1(1): 12-16
    » Abstract » doi: 10.31838/ijprt/01.01.03
    Cited : 2 times [Click to see citing articles]

  • EFFECT OF SEED EXTRACTS OF Elettaria cardamomum ON CALCIUM OXALATE CRYSTALLIZATION
    Manish A. Patel, Paras K. Patel, Dr. Avinash K Seth
    IJPRT. 2011; 1(1): 21-25
    » Abstract » doi: 10.31838/ijprt/01.01.05
    Cited : 2 times [Click to see citing articles]