E-ISSN 2250-0944 | ISSN 2250-1150
 

Research Article 


Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia

MEGHANA ROWTHU, VENU MADHAV KATLA.

Abstract
The objective of the work was to formulate and evaluate solid lipid nanoparticles loaded with clozapine for use in the treatment of schizophrenia. Solid Lipid Nanoparticles was prepared by precipitation method using soya lecithin, sodium glycolate. The drug-polymer incompatibility was ruled out by FTIR studies. Evaluation studies like drug content, entrapment efficiency, particle size distribution, zeta potential and in-vitro drug release, for formulation was performed. From the FTIR studies, the drug-polymers compatibility was confirmed, that, the polymer did not interfere with the drug used. Nanoparticles formulations were found to be in solid dispersion form. The entrapment efficiency of the formulation varied from 20.03-52.30 %. The zeta potential was found to be in range of to -4.42 mv to -74.6 mv. The most ideal formulation was F4 since it showed good In-vitro drug release of 94.79 % release at the end of 12 hours. From this study it could be concluded that the formulated solid lipid nanoparticles of clozapine showed good and effective release.

Key words: Clozapine; soya lecithin; sodium glycolate; FTIR; Entrapment efficiency; In-vitro drug release, zeta potential.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by MEGHANA ROWTHU
Articles by VENU MADHAV KATLA
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT. 2023; 13(2): 115-125. doi:10.31838/ijprt/13.02.12


Web Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. https://www.ijprt.org/?mno=141817 [Access: March 02, 2023]. doi:10.31838/ijprt/13.02.12


AMA (American Medical Association) Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT. 2023; 13(2): 115-125. doi:10.31838/ijprt/13.02.12



Vancouver/ICMJE Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT. (2023), [cited March 02, 2023]; 13(2): 115-125. doi:10.31838/ijprt/13.02.12



Harvard Style

MEGHANA ROWTHU , VENU MADHAV KATLA (2023) Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT, 13 (2), 115-125. doi:10.31838/ijprt/13.02.12



Turabian Style

MEGHANA ROWTHU , VENU MADHAV KATLA. 2023. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. International Journal of Pharmacy Research & Technology, 13 (2), 115-125. doi:10.31838/ijprt/13.02.12



Chicago Style

MEGHANA ROWTHU , VENU MADHAV KATLA. "Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia." International Journal of Pharmacy Research & Technology 13 (2023), 115-125. doi:10.31838/ijprt/13.02.12



MLA (The Modern Language Association) Style

MEGHANA ROWTHU , VENU MADHAV KATLA. "Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia." International Journal of Pharmacy Research & Technology 13.2 (2023), 115-125. Print. doi:10.31838/ijprt/13.02.12



APA (American Psychological Association) Style

MEGHANA ROWTHU , VENU MADHAV KATLA (2023) Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. International Journal of Pharmacy Research & Technology, 13 (2), 115-125. doi:10.31838/ijprt/13.02.12





Most Viewed Articles
  • Stability Indicating HPLC Method for Simultaneous Estimation of Nicotinamide and Salicylic Acid
    FALGUNI TANDEL, PRATIMA MORE
    IJPRT. 2018; 8(2): 43-47
    » Abstract » doi: 10.31838/ijprt/08.02.05

  • FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE
    ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.
    IJPRT. 2018; 8(2): 14-26
    » Abstract » doi: 10.31838/ijprt/08.02.02

  • Antimicrobial activities, antioxidant and phytochemical analysis of methanol and aqueous leaf extract of Phyllathus muellerianus (KUNTZ) Exell
    FRED COOLBORN AKHARAIYI* ,ABAYOMI OLABANJO DINA
    IJPRT. 2018; 8(1): 29-38
    » Abstract » doi: 10.31838/ijprt/08.01.04

  • Pharmacovigilance system and the future challenges in India-A Perspective
    *SANDHYA JAIN*, 1DR VIKAS JAIN, 2RADHA SHARMA
    IJPRT. 2018; 8(2): 27-31
    » Abstract » doi: 10.31838/ijprt/08.02.03

  • Piperine : A Bioenhancer
    Amar Singh*, Amar Deep
    IJPRT. 2011; 1(1): 1-5
    » Abstract » doi: 10.31838/ijprt/01.01.01

  • Most Downloaded
  • A case report on sympneumonic effusion
    Sandeep Akkam, Pooja dasari, Nandini Thota,
    IJPRT. 2021; 11(2): 17-18
    » Abstract » doi: 10.31838/ijprt/11.02.02

  • RELEASE KINETICS – CONCEPTS AND APPLICATIONS
    M. PADMAA PAARAKH , PREETHY ANI JOSE* , CM SETTY , G.V. PETER CHRISTOPER
    IJPRT. 2018; 8(1): 12-20
    » Abstract » doi: 10.31838/ijprt/08.01.02

  • FORMULATION AND EVALUATION OF ACTIVATED CHARCOAL PEEL OFF MASK
    SWETA V.KULKARNI*, DR.ARUN K.GUPTA, SHUBHAM BHAWSAR
    IJPRT. 2019; 9(2): 44-48
    » Abstract » doi: 10.31838/ijprt/09.02.06

  • Medicinal vegetal use by traditional healers in Ekiti State of Nigeria for diabetes treatment
    AKHARAIYI, FRED COOLBORN , ADEROBA ADEYEMI ADEGBEMISIPO
    IJPRT. 2018; 8(1): 21-28
    » Abstract » doi: 10.31838/ijprt/08.01.03

  • FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE
    ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.
    IJPRT. 2018; 8(2): 14-26
    » Abstract » doi: 10.31838/ijprt/08.02.02

  • Most Cited Articles
  • Piperine : A Bioenhancer
    Amar Singh*, Amar Deep
    IJPRT. 2011; 1(1): 1-5
    » Abstract » doi: 10.31838/ijprt/01.01.01
    Cited : 5 times [Click to see citing articles]

  • Biodiversity and conservation Ferns Diversity in different forests of Dehradun district
    CHHAYA SINGH, BRIJESH KUMAR, ANJU RANI, KAMLA DHYANI, RAJ SINGH
    IJPRT. 2017; 7(2): 01-07
    » Abstract » doi: 10.31838/ijprt/07.02.01
    Cited : 3 times [Click to see citing articles]

  • Stability Indicating HPLC Method for Simultaneous Estimation of Nicotinamide and Salicylic Acid
    FALGUNI TANDEL, PRATIMA MORE
    IJPRT. 2018; 8(2): 43-47
    » Abstract » doi: 10.31838/ijprt/08.02.05
    Cited : 3 times [Click to see citing articles]

  • A Preliminary Investigation of Moringa Oleifera Lam Gum As a Pharmaceutical Excipient
    Dhiren P Shah*, Vineet C Jain, Hitesh P Dalvadi, Vinod D Ramani, Kajal G Patel, Mahesh G Saralai, Girish K Jani
    IJPRT. 2011; 1(1): 12-16
    » Abstract » doi: 10.31838/ijprt/01.01.03
    Cited : 2 times [Click to see citing articles]

  • EFFECT OF SEED EXTRACTS OF Elettaria cardamomum ON CALCIUM OXALATE CRYSTALLIZATION
    Manish A. Patel, Paras K. Patel, Dr. Avinash K Seth
    IJPRT. 2011; 1(1): 21-25
    » Abstract » doi: 10.31838/ijprt/01.01.05
    Cited : 2 times [Click to see citing articles]