Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia

MEGHANA ROWTHU; VENU MADHAV KATLA

doi:10.31838/ijprt/13.02.12

2023, Vol: 13, Issue: 2

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Research Article

IJPRT. 2023; 13(2): 115-125

doi: 10.31838/ijprt/13.02.12

Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia

MEGHANA ROWTHU, VENU MADHAV KATLA.

Abstract
The objective of the work was to formulate and evaluate solid lipid nanoparticles loaded with clozapine for use in the treatment of schizophrenia. Solid Lipid Nanoparticles was prepared by precipitation method using soya lecithin, sodium glycolate. The drug-polymer incompatibility was ruled out by FTIR studies. Evaluation studies like drug content, entrapment efficiency, particle size distribution, zeta potential and in-vitro drug release, for formulation was performed. From the FTIR studies, the drug-polymers compatibility was confirmed, that, the polymer did not interfere with the drug used. Nanoparticles formulations were found to be in solid dispersion form. The entrapment efficiency of the formulation varied from 20.03-52.30 %. The zeta potential was found to be in range of to -4.42 mv to -74.6 mv. The most ideal formulation was F4 since it showed good In-vitro drug release of 94.79 % release at the end of 12 hours. From this study it could be concluded that the formulated solid lipid nanoparticles of clozapine showed good and effective release.

Key words: Clozapine; soya lecithin; sodium glycolate; FTIR; Entrapment efficiency; In-vitro drug release, zeta potential.

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Pubmed Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT. 2023; 13(2): 115-125. doi:10.31838/ijprt/13.02.12

Web Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. https://www.ijprt.org/?mno=141817 [Access: March 02, 2023]. doi:10.31838/ijprt/13.02.12

AMA (American Medical Association) Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT. 2023; 13(2): 115-125. doi:10.31838/ijprt/13.02.12

Vancouver/ICMJE Style

MEGHANA ROWTHU , VENU MADHAV KATLA. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT. (2023), [cited March 02, 2023]; 13(2): 115-125. doi:10.31838/ijprt/13.02.12

Harvard Style

MEGHANA ROWTHU , VENU MADHAV KATLA (2023) Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. IJPRT, 13 (2), 115-125. doi:10.31838/ijprt/13.02.12

Turabian Style

MEGHANA ROWTHU , VENU MADHAV KATLA. 2023. Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. International Journal of Pharmacy Research & Technology, 13 (2), 115-125. doi:10.31838/ijprt/13.02.12

Chicago Style

MEGHANA ROWTHU , VENU MADHAV KATLA. "Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia." International Journal of Pharmacy Research & Technology 13 (2023), 115-125. doi:10.31838/ijprt/13.02.12

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

MEGHANA ROWTHU , VENU MADHAV KATLA (2023) Preparation And Evaluation of Clozapine Loaded Solid Lipid Nanoparticles for Treatment of Schizophrenia. International Journal of Pharmacy Research & Technology, 13 (2), 115-125. doi:10.31838/ijprt/13.02.12

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