E-ISSN 2250-0944 | ISSN 2250-1150
 

Research Article 


Formulation and Evaluation of Buccal Patches of Timolol Maleate

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR.

Abstract
The present investigation is concerned with the formulation and development of controlled release mucoadhesive buccal patch of Timolol maleate using natural and synthetic polymers. Timolol maleate is a non-selective beta-adrenergic blocker, and having short biological half-life, approximate 4.1 h, and low oral bioavailability. Therefore in order to control the release and increase the residence time these formulations are carried out. Natural polymer such as Chitosan and Synthetic polymers such as HPMC K15M and Eudragit RL100 were used to formulate the buccal patches. Various grades of Tween are used to increase the permeation capacity of the patch. All the formulations were evaluated for Weight Uniformity, Thickness, Folding Endurance, Swelling Index, Drug Content Uniformity, Tensile Strength and In vitro Drug Release. From all the prepared formulations, F6 showed good drug release characteristic. Drug release from the patches follows desire controlled release phenomenon as needed in buccoadhesive drug delivery.

Key words: Controlled release, Chitosan, Tween, Tensile strength


 
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How to Cite this Article
Pubmed Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. Formulation and Evaluation of Buccal Patches of Timolol Maleate. IJPRT. 2023; 13(2): 46-51. doi:10.31838/ijprt/13.02.06


Web Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. Formulation and Evaluation of Buccal Patches of Timolol Maleate. https://www.ijprt.org/?mno=137817 [Access: March 01, 2023]. doi:10.31838/ijprt/13.02.06


AMA (American Medical Association) Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. Formulation and Evaluation of Buccal Patches of Timolol Maleate. IJPRT. 2023; 13(2): 46-51. doi:10.31838/ijprt/13.02.06



Vancouver/ICMJE Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. Formulation and Evaluation of Buccal Patches of Timolol Maleate. IJPRT. (2023), [cited March 01, 2023]; 13(2): 46-51. doi:10.31838/ijprt/13.02.06



Harvard Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR (2023) Formulation and Evaluation of Buccal Patches of Timolol Maleate. IJPRT, 13 (2), 46-51. doi:10.31838/ijprt/13.02.06



Turabian Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. 2023. Formulation and Evaluation of Buccal Patches of Timolol Maleate. International Journal of Pharmacy Research & Technology, 13 (2), 46-51. doi:10.31838/ijprt/13.02.06



Chicago Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. "Formulation and Evaluation of Buccal Patches of Timolol Maleate." International Journal of Pharmacy Research & Technology 13 (2023), 46-51. doi:10.31838/ijprt/13.02.06



MLA (The Modern Language Association) Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR. "Formulation and Evaluation of Buccal Patches of Timolol Maleate." International Journal of Pharmacy Research & Technology 13.2 (2023), 46-51. Print. doi:10.31838/ijprt/13.02.06



APA (American Psychological Association) Style

VELPOOR DIVYA, G.S.VALLURI, G.VIJAY KUMAR (2023) Formulation and Evaluation of Buccal Patches of Timolol Maleate. International Journal of Pharmacy Research & Technology, 13 (2), 46-51. doi:10.31838/ijprt/13.02.06





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