Antibiotic Regimens for Uncomplicated Urogenital  Gonorrhoea, with a Focus on Urethral Infection, in the  Era of Emerging Resistance: A Systematic Review and  Network Meta-Analysis of Randomised Trials Including  Zoliflodacin and Gepotidacin

Ni Made Wiliantari, Ketut Kwartantaya Winaya

Antibiotic Regimens for Uncomplicated Urogenital Gonorrhoea, with a Focus on Urethral Infection, in the Era of Emerging Resistance: A Systematic Review and Network Meta-Analysis of Randomised Trials Including Zoliflodacin and Gepotidacin

Authors

Ni Made Wiliantari, Ketut Kwartantaya Winaya

Keywords:

Gonorrhoea, Neisseria gonorrhoeae, Network meta-analysis, Zoliflodacin, Gepotidacin, Ceftriaxone, Urethritis, Antimicrobial resistance

Abstract

Background/Objectives: Zoliflodacin and gepotidacin, two first-in-class oral agents, have recentlybeen approved for uncomplicated urogenital gonorrhoea, but they have not been compared with eachother or with all contemporary alternatives. We compared the efficacy and safety of current antibiotic regimens, with a focus on urethral infection

References

1. Rowley, J., Vander Hoorn, S., Korenromp, E., Low, N., Unemo, M., Abu-Raddad, L. J., Chico, R. M., Smolak, A., Newman, L., Gottlieb, S., Thwin, S. S., Broutet, N., & Taylor, M. M. (2019). Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates,

2016. Bulletin of the World Health Organization, 97(8), 548-562P. https://doi.org/10.2471/BLT.18.228486

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Published

2026-11-02

How to Cite

Ni Made Wiliantari, Ketut Kwartantaya Winaya. (2026). Antibiotic Regimens for Uncomplicated Urogenital Gonorrhoea, with a Focus on Urethral Infection, in the Era of Emerging Resistance: A Systematic Review and Network Meta-Analysis of Randomised Trials Including Zoliflodacin and Gepotidacin. International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 7610–7620. Retrieved from https://www.ijprt.org/index.php/pub/article/view/3514