Study of Extra Pulmonary Tuberculosis using Gene X-pert and Fluorescent Microscopy at Vasantrao Naik GMC Yavatmal

Abstract

Background: Tuberculosis remains a major global health problem with 1/3 of world’s population being infected with tuberculosis Along with HIV, Diabetes mellitus and recently evolved drug resistant tuberculosis, it is a big threat for mankind. TB can involve any organ system in the body. While PTB is the most common presentation, EPTB is also an important clinical problem.

Aim and Objectives: 1. Study of Extra Pulmonary Tuberculosis using Gene X-pert and Fluorescent Microscopy at Vasantrao Naik GMC Yavatmal.2. Study the age and gender wise distribution of Extra pulmonary tuberculosis patient.3. Finding associated risk factors with extra pulmonary tuberculosis

Methods: Study Design: Cross sectional study. Study Population: All extra pulmonary suspected patients admitted in Vasantrao Naik GMC Yavatmal during study period such cases were included in the study. Study Duration: 2023-2025 Sample size: 246

Results: Most of the EPTB cases found in 26-40 years age group 87 (36.25%) followed by 62 cases (25.83%) in 41-55 years age group, 39 (16.25%) in 12-25 age group,37 (15.41%) in 56-65 age group and 21 cases found in above 66 years age group. majority of EPTB cases were males 149 (60.56%) and females were 97 (39.44%). EPTB cases as per diagnosis majority of cases were males 149 and 97 cases were females. In males most of cases diagnosed pleural TB 69 (46.30%) followed by lymph node TB 32 (21.47%), abdominal TB 27 (18.12%), potts spine 12 (8.05%), TB meningitis 4 (2.68%), peritoneal TB 4 (2.68%) and genital TB 1 (0.67%). Association of Pleural TB cases with age was statistically significant at p<.05. Sensitivity and specificity of Gene X-pert and Fluorescent Sensitivity=89.43%, Specificity= 70.58%, Positive Predictive value = 94.82% and Negative Predictive value = 16.12%

Conclusions: Most of the EPTB cases found in 26-40 years age group, majority of EPTB cases were males, In males most of cases diagnosed pleural TB, Association of Pleural TB cases with age was statistically significant at p<.05. Sensitivity and specificity of Gene X-pert and Fluorescent Sensitivity=89.43%, Specificity= 70.58%, Positive Predictive value = 94.82% and Negative Predictive value = 16.12%