Comparison of Alpha-Blocker Monotherapy Versus Combination Therapy in  Moderate to Severe LUTS: A Real-World Study

Muhammad Haroon Ghous, Umer Saeed, Mudassara Saqib, Maliha Karim, Farooq Sultan, Muhammad Nouman Khan

Comparison of Alpha-Blocker Monotherapy Versus Combination Therapy in Moderate to Severe LUTS: A Real-World Study

Authors

Muhammad Haroon Ghous, Umer Saeed, Mudassara Saqib, Maliha Karim, Farooq Sultan, Muhammad Nouman Khan

Keywords:

lower urinary tract symptoms; α-blockers; combination therapy

Abstract

Lower urinary tract symptoms (LUTS) in men significantly impair quality of life and arecommonly managed using α-blockers as first-line therapy, with or without the addition of 5αreductase inhibitors (5-ARIs). This real-world, prospective comparative study evaluated the effectiveness of α-blocker monotherapy versus α-blocker plus

References

Roehrborn CG, et al. Long-term outcomes of combination therapy in LUTS. J Clin Med. 2022;11(3):655.

Gravas S, et al. Management of non-neurogenic male LUTS. Eur Urol. 2022;82(5):463478.

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Published

2025-08-30

How to Cite

Muhammad Haroon Ghous, Umer Saeed, Mudassara Saqib, Maliha Karim, Farooq Sultan, Muhammad Nouman Khan. (2025). Comparison of Alpha-Blocker Monotherapy Versus Combination Therapy in Moderate to Severe LUTS: A Real-World Study . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 1674–1680. Retrieved from https://www.ijprt.org/index.php/pub/article/view/948