Pediatric Beta-Thalassemia Major: Chronic Transfusion, Oxidative Stress, and the Overlooked Surgical Burden

Authors

  • Junaid Ahmed, Tahir Shahzad Nawaz Babar, Tabassum Bashir, Abid Ali Ranjha, Hamza Sohail, Azal Jodat

Keywords:

Beta-thalassemia major; chronic transfusion; oxidative stress; ferritin; splenectomy; pediatric surgical burden

Abstract

Association between chronic transfusion therapy, oxidative stress biomarkers, and surgicalinterventions in pediatric patients with beta-thalassemia major was evaluated in a prospectivecohort of 200 children aged 5–16 years receiving regular transfusions and chelation therapy. Serummarkers including malondialdehyde

References

Ahmed, M., & Yenzeel, W. (2021). Oxidative stress markers in pediatric beta-thalassemia major: Malondialdehyde, antioxidant enzymes, and iron overload. Pediatric Hematology Reports, 12(3), 145–152.

Al-Zahraa Sherai, F., Mabrouk, M., Badraia, I., Hagag, A., & Elaskary, E. (2025). Vascular endothelial dysfunction and oxidative stress in children with beta-thalassemia major: A quercetin intervention study. Egyptian Pediatric Association Gazette, 73, Article 9.

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Published

2025-08-25

How to Cite

Junaid Ahmed, Tahir Shahzad Nawaz Babar, Tabassum Bashir, Abid Ali Ranjha, Hamza Sohail, Azal Jodat. (2025). Pediatric Beta-Thalassemia Major: Chronic Transfusion, Oxidative Stress, and the Overlooked Surgical Burden. International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 1509–1516. Retrieved from https://www.ijprt.org/index.php/pub/article/view/919

Issue

Section

Research Article