FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE.

Abstract

The aim of the present study was to formulate and develop Nanoparticulate drug delivery system (Nanostructured Lipid Carrier) for the treatment of Acne. The nanostructured lipid carrier was prepared by high speed and high pressure homogenizer by using different types of solid lipid, liquid lipid and concentration of surfactants. The NLC was characterized by particle size, zeta potential, polydispersity index. Stearic acid and oleic acid were used as solid lipid and liquid lipid and Pluronic F-68 was used as surfactant. The drug excipient compatibility study was performed by Fourier transform infrared spectrophotometer and the result revealed that all the excipients and drugs were compatible with each other. For the drug estimation HPLC method was developed for the combined drug Clindamycin phosphate and Nicotinamide. Formulation of nanoemulsion was prepared by high speed and high pressure homogenization technique. This emulsion was incorporated into the gel which was prepared by using Carbopol 934P as gel base and evaluated for the In-vitro release. Factorial design was used for the evaluation and optimization of the nanoparticles. Short termstability study was performed for 30 days and there was no significant change in consistency, pH and viscosity.