Assessment of Serum Alpha-Fetoprotein, Triphasic CT, and Renal Parameters in the Early Detection of Hepatocellular Carcinoma

Authors

  • Aysha Abdul Rauf Nazir Ahmed, Ali Saqlain Haider, Muhammad Hamza Bajwa, Muhammad Adnan Sadiq, Sumera Saghir, Irfana Hassan

Keywords:

alpha-fetoprotein; hepatocellular carcinoma; triphasic CT; renal parameters; albuminuria.

Abstract

Early detection of hepatocellular carcinoma (HCC) remains critical to enable curative therapies and improve survival. The present case-control study evaluates three modalities—serum alphafetoprotein (AFP), triphasic computed tomography (CT) imaging, and selected renal parameters (serum creatinine, estimated glomerular filtration rate [eGFR], and albuminuria)—for their utility in identifying early-stage HCC among high-risk patients with chronic liver disease.

References

Tzartzeva K, Obi J, Rich NE, et al. Surveillance imaging and alpha-fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis.Gastroenterology. 2018;154(6):1706-1718.e1. (PubMed Central)

Daif A, Al-Azzawi MA, Sakr MA, Ismail HA, Gadallah M. Noninvasive identification of molecular biomarkers of hepatocellular carcinoma in HCV-Egyptian patients. J Egypt Natl Canc Inst. 2023;35:11. (SpringerOpen)

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Published

2025-10-28

How to Cite

Aysha Abdul Rauf Nazir Ahmed, Ali Saqlain Haider, Muhammad Hamza Bajwa, Muhammad Adnan Sadiq, Sumera Saghir, Irfana Hassan. (2025). Assessment of Serum Alpha-Fetoprotein, Triphasic CT, and Renal Parameters in the Early Detection of Hepatocellular Carcinoma. International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 2809–2817. Retrieved from https://www.ijprt.org/index.php/pub/article/view/1121

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Section

Research Article