E-ISSN 2250-0944 | ISSN 2250-1150
 

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Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara.

Abstract
Extended release tablets of Metformin HCl were developed due to lower half-life, high solubility and less bioavailability. The tablets were prepared by hydrophilic matrix technique and combination of hydrophilic matrix with hydrophobic coating as reservoir. Hypromellose was used as matrixing agent and ethyl cellulose as hydrophobic coating material. In vitro dissolution studies of optimized, F3a (3% coated) formulation showed satisfactory results for f2 and f1 values i.e 80.29 and 2.87 respectively. And the dissolution profile was almost similar with that of reference product. The results of the dissolution study were examined according to Zero, First and Higuchi model as shown for reference product. The regression coefficient (R2) value obtained from the log %ARR (Amount Remaining to Release) versus time was 0.9396 which is nearer to 1, indicating first order release for formulation F3a. Results of stability study carried out on formulation F3a for three months indicated that, there was no any significant change in drug release of the tablet as well as % assay results were found within specifications. Hence, the optimized formulation was stable.

Key words: Type II diabetes, Hypromellose, Extended release, Metformin HCl, Matrix tablets


 
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Pubmed Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. IJPRT. 2012; 2(2): 18-23. doi:10.31838/ijprt/02.02.05


Web Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. https://www.ijprt.org/?mno=302643716 [Access: June 25, 2022]. doi:10.31838/ijprt/02.02.05


AMA (American Medical Association) Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. IJPRT. 2012; 2(2): 18-23. doi:10.31838/ijprt/02.02.05



Vancouver/ICMJE Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. IJPRT. (2012), [cited June 25, 2022]; 2(2): 18-23. doi:10.31838/ijprt/02.02.05



Harvard Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara (2012) Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. IJPRT, 2 (2), 18-23. doi:10.31838/ijprt/02.02.05



Turabian Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. 2012. Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. International Journal of Pharmacy Research & Technology, 2 (2), 18-23. doi:10.31838/ijprt/02.02.05



Chicago Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. "Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets." International Journal of Pharmacy Research & Technology 2 (2012), 18-23. doi:10.31838/ijprt/02.02.05



MLA (The Modern Language Association) Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara. "Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets." International Journal of Pharmacy Research & Technology 2.2 (2012), 18-23. Print. doi:10.31838/ijprt/02.02.05



APA (American Psychological Association) Style

Nishit Gohel, D. M. Patel, Komal Patel, Rushik Ghodasara (2012) Formulation Development and Evaluation of Metformin Hydrochloride Extended Release Tablets. International Journal of Pharmacy Research & Technology, 2 (2), 18-23. doi:10.31838/ijprt/02.02.05





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